Progress and development in Parkinson disease therapy

  • Carsten R. Bjarkam
  • Jens C. SØrensen


Parkinson disease (PD) is a common neurodegenerative disorder affecting 1% of the population aged seventy or more. The causes of PD remain obscure, but basic and clinical research has led to a deep insight into PD pathophysiology, identifying several points of intervention for emerging therapeutic strategies enabling modulation of neural circuits and replacement of lost neurons, neurotransmitters, and neurotrophic factors. ∈dent In this chapter we aim, accordingly, to present a overview of the current knowledge on PD pathophysiology and demonstrate how this knowledge provides targets for current and future pharmacological and surgical treatment strategies towards PD


Basal ganglia circuitry Current & future interventions Neuroprotection Pharmacological treatment Surgical treatment 


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Copyright information

© Springer 2006

Authors and Affiliations

  • Carsten R. Bjarkam
    • 1
  • Jens C. SØrensen
    • 2
  1. 1.Department of NeurobiologyInstitute of AnatomyUniversity of AarhusDenmark
  2. 2.Department of NeurosurgeryUniversity Hospital of AarhusAarhus

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