Protein Aggregation in Aging and Age-Related Neurodegenerative Disorders

  • Jeffrey N. Keller
  • Qunxing Ding


The purpose of this chapter is to provide a background on the effects of aging on proteolytic pathways and protein aggregation, and to discuss the contribution of altered protease function and protein aggregation to brain function. Studies will focus on the proteasome proteolytic pathway. Lastly, these studies will also discuss the relationship between aging and age-related neurodegenerative disorders


Aging Alzheimer’s disease lysosome neuron oxidative stress proteasome 


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Copyright information

© Springer 2006

Authors and Affiliations

  • Jeffrey N. Keller
    • 1
    • 2
  • Qunxing Ding
    • 1
  1. 1.Anatomy and Neurobiology Sanders-Brown Center on AgingUniversity of KentuckyLexingtonUSA
  2. 2.Sanders-Brown Center on AgingUniversity of KentuckyLexington

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