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Radiation Risk Estimates in Normal and Emergency Situations pp 341–359Cite as

GENOME RECONSTITUTION IN THE EXTREMELY RADIATION RESISTANT BACTERIUM Deinococcus radiodurans

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Part of the book series: NATO Security through Science Series ((NASTB))

Abstract

The bacterium Deinococcus radiodurans is highly resistant to the effects of ionizing radiation, (IR). Cultures of Deinococcus survive exposure to IR doses of 5,000 Gray (Gy) with no lethality. At 5,000 Gy, several hundred double strand breaks are introduced into the genome. Recovery from this DNA damage occurs in two phases, one independent of RecA protein and one that requires RecA. A number of proteins are induced in Deinococcus in response to exposure to ionizing radiation, and many of those most highly expressed are novel proteins. A variety of Deinococcus proteins involved in genome reconstitution are now under biochemical investigation. Many of these proteins exhibit unusual properties, but a complete explanation for the radiation resistance of Deinococcus is not yet available.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, 70803, Louisiana, USA

    JOHN R. BATTISTA

  2. Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Dr, 53706-1544, Madison, Wisconsin, USA

    MICHAEL M. COX

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  1. JOHN R. BATTISTA
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Editors and Affiliations

  1. Past-President Union Internationale de Radioecologie, Cocconato (Asti), Italy

    Arrigo A. Cigna

  2. University Federico II, Napoli, Italy

    Marco Durante

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BATTISTA, J.R., COX, M.M. (2006). GENOME RECONSTITUTION IN THE EXTREMELY RADIATION RESISTANT BACTERIUM Deinococcus radiodurans. In: Cigna, A.A., Durante, M. (eds) Radiation Risk Estimates in Normal and Emergency Situations. NATO Security through Science Series. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4956-0_34

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