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Non-Pesticide Endocrine Disrupters And Reproductive Health

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Reproductive Health and the Environment

Part of the book series: Environmental Science and Technology Library ((ENST,volume 22))

Summary

Persistent organic pollutants (POPs) include several groups of chemicals with similar structures and physical-chemical properties that elicit similar toxic effects. They have been used worldwide in agriculture (pesticides), industrial and health applications. Some POPs mimic natural hormones and are defined as endocrine disrupter compounds (EDCs), meaning that they are able to interfere with functions of the endocrine system; in fact, damage to the endocrine system is the first detectable effect. Non-pesticide EDCs are oestrogen agonists or antagonists, and as such may be responsible for the recent increase in reproductive pathologies in many species, including humans.

The link between EDC exposure and effect is not always clear or easily demonstrable; in fact the causes of health and reproductive problems in humans and wildlife are often difficult to understand, because many factors contribute to them. A link has been demonstrated, however, in accidental exposure to xenobiotics and the causation of health problems, including reproductive impairments in people exposed to them. Evidence of reproductive problems has also been reported in wildlife. Numerous experiments demonstrate the link between EDC concentration in tissues and reproductive impairment. EDC contamination is responsible for reducing sperm count and quality, female fertility and sex ratio. It is also responsible for inducing several types of cancer in both the male and female reproductive systems, and in these cases infertility may be a consequence of the cancer.

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References

  • Aitken, R.J., Koopman, P., and Lewis, S.E.M. (2004) Seeds of concern, Nature 432, 48-52.

    Article  CAS  Google Scholar 

  • Alaee, M., Arias, P., Sjödin, A., and Bergman, A. (2003) An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release, Environ. Int. 29, 683-689.

    Article  CAS  Google Scholar 

  • Ankley, G.T., Johnson, R.D., Toth, G., Folmar, L.C., Detenbeck, N.E., and Bradbury, S.P. (1997) Development of a Research Strategy for Assessing the Ecological Risk of Endocrine Disrupters, Review Toxicology Ser. B: Environ. Toxicol, pp 78.

    Google Scholar 

  • ATSDR - Agency for Toxic Substances and Disease Registry ( 1998) Toxicological Profile for Chlorinated Dibenzo-p-dioxins. Update (Final Report). NTIS Accession No. PB99-121998. Atlanta, GA: Agency for Toxic Substances and Disease Registry, 729.

    Google Scholar 

  • Auman, H.J., Ludwig, J.P., Summer, C.L., Verbrugge, D.A., Froese, K.L., Colborn, T., and Giesy, J.P. (1997) PCBs, DDE, DDT, and TCDD-EQ in two species of albatross on Sand Island, Midway Atoll, North Pacific Ocean, Environ. Toxicol. Chem. 16, 498-504.

    Article  CAS  Google Scholar 

  • Becher, H., and Flesch-Janys, D. (1998) Dioxins and Furans: Epidemiologic Assessment of Cancer Risks and Other Human Health Effects, Environ. Health Perspect. 106, 623.

    Article  Google Scholar 

  • Bergeron, J.M., Crews, D., and McLachlan, J.A. (1994) PCBs as environmental oestrogen: turtle sex determination as biomarkers of environmental contamination, Environ. Health Perspect. 102, 780-781.

    Article  CAS  Google Scholar 

  • Bergman, A., Biessmann, A., Brandt, I., and Rafter, J. (1982) Metabolism of 2,4,5-trichlorobiphenyl: role of the intestinal microflora in the formation of bronchial-seeking methylsulphone metabolites in mice, Chemico-Biological Interactions. 40, 123-131.

    Article  CAS  Google Scholar 

  • Bertazzi, P.A., Bernucci, I., Brambilla, G., Consonni, D., and Pesatori, A.C. (1998) The Seveso Studies on Early and Long-Term Effects of Dioxin Exposure: A Review, Environ. Health Perspect. 106, 625-634.

    Article  CAS  Google Scholar 

  • Birnbaum, L.S., and Staskal, D.F. (2004) Brominated flame retardants: Cause for concern? Environ. Health Perspect. 112, 9-17.

    Article  CAS  Google Scholar 

  • Bishop, C.A., Brooks, R.J., Carey, J.H., Ng, P., Norstrom, R.J., Lean, D.R.S.J. (1991) The case for a cause-effect linkage between environmental contamination and development in eggs of the common snapping turtle (Chelydra s. serpentina) from Ontario, Canada. J. Toxicol. Environ. Health. 33, 521-548.

    Article  CAS  Google Scholar 

  • Boon, J.P., Lewis, W.E., Tjoen-A-Choy, M.R., Allchin, C.R., Law, R.J., de Boer, J., Ten Hallers-Tjabbes, C., and Zegers, B.N. (2002) Levels of polybrominated diphenyl ether (PBDE) flame retardants in animals representing different trophic levels of the North Sea food web, Environ. Sci. Tech. 36, 4025-4032.

    Article  CAS  Google Scholar 

  • Borrell, A., Aguilar, A., Corsolini, S., and Focardi, S. (1996) Evaluation of toxicity and sex-related variation of PCB levels in Mediterranean Striped Dolphin affected by an epizootic, Chemosphere 32, 2359-2369.

    Article  CAS  Google Scholar 

  • Brouwer, A., Reijnders, P.J.H., and Koeman, J.H. (1989) Polychlorinated biphenyl (PCB)-contaminated fish induces vitamin A and thyroid hormone deficiency in the common seal (Phoca vitulina), Aqua. Toxicol. 15, 99-106.

    Article  CAS  Google Scholar 

  • Brunstrom, B. (1989). Toxicity of coplanar polychlorinated biphenyls in avian embryos, Chemosphere 19, 756.

    Article  Google Scholar 

  • Brunstrom, B. (1990) Mono-ortho-chlorinated chlorobiphenyls: toxicity and induction of 7-ethoxiresorufin-O-deethylase (EROD) activity in chick embryios, Archives Toxicol. 64, 188-192.

    Article  CAS  Google Scholar 

  • Bush, B., Bennett, A., and Snow, J. (1986) Polychlorobiphenyl congeners, p,p’-DDE, and sperm function in humans, Arch. Environ. Contam. Toxicol. 15, 333-341.

    Article  CAS  Google Scholar 

  • Butler, D. (2004) The fertility riddle, Nature 432, 38-39.

    Article  CAS  Google Scholar 

  • Chitra, K.C., and Mathur, P.P. (2004) Vitamin E prevents nonylphenol-induced oxidative stress in testis of rats, Ind. J. Experi. Biol. 42, 220–223.

    CAS  Google Scholar 

  • Colborn, T., and Clement, C. (eds.) ( 1992) Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection, Princeton Scientific Publishing Co., Inc. Princeton, NJ (1992).

    Google Scholar 

  • Colborn, T., vom Saal, F.S., and Soto, A.M. (1993) Developmental Effects of Endocrine-disrupting Chemicals in Wildlife and Humans, Environ. Health Perspect. 101, 378-384.

    Article  CAS  Google Scholar 

  • Corsolini, S., Kannan, K., Imagawa, T., Focardi, S., and Giesy, J.P., (2002) Polychloronaphthalenes and other dioxin-like compounds in Arctic and Antarctic marine food webs, Environ. Sci. Tech. 36, 3490-3496.

    Article  CAS  Google Scholar 

  • Corsolini, S., Covaci, A., Ademollo, N., Focardi, S., and Schepens, P. ( 2005) Occurrence of organochlorine pesticides (OCPs) and their enantiomeric signatures, and concentrations of polybrominated diphenyl ethers (PBDEs) in the Adélie penguin food web, Antarctica, Environ. Pollut. 140, 371-382.

    Article  CAS  Google Scholar 

  • Dallinga, J.W., Moonen, E.J., Domoulin, J.C., Evers, J.L., Geraedts, J.P., and Kleinjans, J.C. (2002) Decreased human semen quality and organochlorine compounds in blood, Hum. Reprod. 17, 1973-1979.

    Article  CAS  Google Scholar 

  • Darnerud, P.O., Eriksen, G.S., Jòhannesson, T., Larsen, P.B., and Viluksela, M. (2001) Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology, Environ. Health Perspect. 109, 49-68.

    Article  CAS  Google Scholar 

  • Davis, S.I., Blanck, H.M., Hertzberg, V.S., Tolbert, P.E., Rubin, C., Cameron L.L., Henderson, A,K., and Marcus M. (2005) Menstrual function among women exposed to polybrominated biphenyls: A follow-up prevalence study, Environ. Health: A Global Access Science Source. 4, 15-29.

    Article  Google Scholar 

  • de Boer, J., de Boer, K., and Boon, J.P. (eds.) ( 2000) New Types of Persistent Halogenated Compounds, In J. Paasavirta. The handbook of Environmental Chemistry, Springer-Verlag, Heidelberg, Germany, pp 61-95, ISBN 3-540-6583-6.

    Google Scholar 

  • de Boer, J., Wester, P.G., Klamer, H.J. C., Lewis, W.E., and Boon, J.P. ( 1998) Do flame retardants threaten ocean life? Nature 394, 28-29.

    Article  Google Scholar 

  • del Rio Gomez, I., Marshall, T., Tsai, P., Shao, Y-S, and Guo, Y.L. (2002) Number of boys born to men exposed to polychlorinated biphenyls, Lancet 360, 143-144.

    Article  CAS  Google Scholar 

  • Den Hond, E., Roels, H.A., Hoppenbrouwers, K., Nawrot, T., Thijs, L., Vandermeulen, C., Winneke, G., Vanderschueren, D., and Staessen, J.A. (2002) Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek’s hypothesis revisited, Environ. Health Perspect. 110, 771-776.

    Article  Google Scholar 

  • DeVito, M.J., Birnbaum, L.S., Farland, W.H., and Gasiewicz, T.A. (1995) Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals, Environ. Health Perspect. 103, 820-831.

    Article  CAS  Google Scholar 

  • EC - European Commission ( 1997) European Workshop on the impact of endocrine disrupters on human health and wildlife, European Commission Report No. EUR 17549, Brussels, European Commission, DGXII (http://europa.eu.int/comm/environment/endocrine/documents/reports_en.htm, last assessed on 24/10 / 2005).

    Google Scholar 

  • EC - European Commission ( 2003) Directive 2003/11/EC of the European Parliament and of the Council of 6 February 2003 amending for the 24th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances and preparations (pentabromodiphenyl ether, octabromodiphenyl ether), Official J European Union, L 42/45 (15.2.2003) (http://europa.eu.int/eur-lex/pri/en/oj/dat/2003/l_042/l_04220030215en00450046.pdf, last assessed 24/10/2005).

    Google Scholar 

  • Elliot, J.E., Norstrom, R.J., Lorenzen, A., Hart, H.E., Philibert, H., Kennedy, J.J., Stegeman, G.D., Bellward, and Cheng, K.M. (1996) Biological Effects of Polychlorinated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls in Bald Eagle (Haliaeetus leucocephalus) Chicks, Environ. Toxicol. Chem. 15, 782-793.

    Article  Google Scholar 

  • EPA - US Environmental Protection Agency (1975) Office of Toxic Substances, Washington D.C. 20460, EPA-560/8-75-001.

    Google Scholar 

  • EPA - US Environmental Protection Agency ( 1989) Interim procedures for estimating risks associated with exposures to mixtures of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs) and 1989 update, Washington, DC: Risk Assessment Forum, EPA/625/3-89/016).

    Google Scholar 

  • Facemire, C.F., Gross, T.S., and Guillette, L.J. (1995) Reproductive impairment in the Florida panther, Environ. Health Perspect. 103, 79-86.

    Article  CAS  Google Scholar 

  • Falandysz, J., Strandberg, L., Bergqvist, P., Kulp, S.E., Strandberg, B., and Rappe, C. (1996) Polychlorinated naphthalenes in sediment and biota from the Gdansk Basin, Baltic Sea, Environ. Sci. Tech. 30, 3266-3274.

    Article  CAS  Google Scholar 

  • Fang, C., Zang C., Xia, G. and Yang, W. (2002) Damaging effects of polychlorinated biphenyls on chicken primordial germ cells.Reproduction, Fertil. Dev. 14, 177-183.

    Article  CAS  Google Scholar 

  • Freeman, H.C., Sangalang, G.B. and Flemming, B. (1982) The sublethal effects of polychlorinated biphenyl (Aroclor 1254) diet on the Atlantic cod Gadus morhua. Sci. Total Environ. 24, 1-11.

    Article  CAS  Google Scholar 

  • Freeman, H.C., Sangalang, G.B. and Uthe, J.F. (1984) The effects of pollutants and contaminants on steroidogenesis in fish and marine mammals. Advances in Environ. Sci. Tech. 16, 197-211.

    CAS  Google Scholar 

  • Giesy, J.P., Ludwig, J.P., and Tillitt, D.E. (1994) Deformities in birds of the Great Lakes Region. Assigning causality, Environ. Sci. Tech. 28, 128-135A.

    Google Scholar 

  • Giesy, J.P., Feyk, L.A., Jones, P. D., Kannan, K. and Sanderson, T. (2003) Review of the effects of endocrine-disrupting chemicals in birds. Pure Appied Chemistry 75, 2287–2303.

    CAS  Google Scholar 

  • Gilbertson, M. (1983) Ethiology of chick edema disease in herring gulls in the lower Great Lakes, Chemosphere 12, 357-370.

    Article  CAS  Google Scholar 

  • Gray, L.E., Ostby, J., Ferrell, J., Rehnberg, G., Linder, R., Cooper, R., Goldman, J., Slott, V., and Laskey, J. (1989) A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat, Fund. Appl. Toxicol. 12, 92-108.

    Article  CAS  Google Scholar 

  • Guo, Y.L., Hsu, P. C., and Lambert, G.H. (2000) Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans, Lancet 356, 1240-1241.

    Article  CAS  Google Scholar 

  • Guzelian, P.S. (1982) Comparative toxicology of chlordecone (kepone) in humans and experimental animals, Annual Review Pharmacol. Toxicol. 22, 89-113.

    Article  CAS  Google Scholar 

  • Hallgren, S., and Darnerud, P.O. (2002) Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects, Toxicology 177, 227-243.

    Article  CAS  Google Scholar 

  • Hennig, B., Reiterer, G., Majkova, Z., Oesterling, E., Meerarani, P., and Toborek, M. (2005) Modification of environmental toxicity by nutrients: implications in atherosclerosis, Cardiovascular Toxicol. 5, 153-160.

    Article  CAS  Google Scholar 

  • Herbst, A., Ulfelder, H., and Poskanzer, D. (1971) Adenocarcinoma of the vagina: association of maternal stilbesterol therapy and tumor appearance in young women, Nat. Engl J. Med. 284, 878-881.

    Article  CAS  Google Scholar 

  • Hester, R.E., and Harrison, R.M. (1999) Endocrine disrupting chemicals. Royal Society of Chemistry, Burlington House, Piccadilly, London, W1J 0BA.

    Google Scholar 

  • Hines, M. (1992) Surrounded by estrogens? Considerations for neurobehavioral development in human beings, In T. Colborn, C. Clement (eds) Chemically induced alterations in sexual and functional development: the wildlife/human connection, Princeton, NJ, Princeton Scientific Publishing, 261-281.

    Google Scholar 

  • HSDB - Hazardous Substances Database ( 2003) 2,3,7,8-tetrachlorodibenzo-p-dioxin, Hazardous Substances Database, National Library of Medicine, http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/$∼ $2e5zMW:1, last assessed on 24, 2005), US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894.

    Google Scholar 

  • Hsu, P.C., Huang, W., Yao, W.J., Wu, M.H., Guo, Y.L., and Lambert, G.H. ( 2003) Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans, J. Am. Med. Assoc. 286, 2943-2944.

    Article  Google Scholar 

  • IARC, International Agency for Research on Cancer (1987) - Summaries & Evaluations, Polybrominated Biphenyls (Group 2B), Supplement 7, p. 321 (http://www.inchem.org/documents/iarc/suppl7/polybrominatedbiphenyls.html, last assessed on 24/10/ 2005).

    Google Scholar 

  • IARC, International Agency for Research on Cancer (1997) Polychlorinated Dibenzo-para-Dioxins and Polychlorinated Dibenzofurans, Summary of Data Reported and Evaluation, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 69, p. 33 (http://www-cie.iarc.fr/htdocs/indexes/vol69index.html, last assessed on 24/10/2005).

    Google Scholar 

  • Ikonomou, M.G., Rayne, S., and Addison, R.F. (2002) Exponential increases of the brominated flame retardants, polybrominated diphenyl ethers, in the Canadian arctic from 1981 to 2000, Environ. Sci. Tech. 36, 1886-1892.

    Article  CAS  Google Scholar 

  • James, W.H. (2002) Sex ratio of offspring born to men exposed to polychlorinated biphenyls. Lancet 360: 1887.

    Article  Google Scholar 

  • Järnberg, U., Asplund, C., de Wit, C., Egebäck, A.L., Wideqvist, U., and Jacobsson, E. (1997) Distribution of polychlorinated naphthalene congeners in environmental and source-related samples, Arch. Environ. Contam. Toxicol. 32, 232-245.

    Article  Google Scholar 

  • Jones, P.B., Galeazzi, D.R., Fisher, J.M., and Whitlock, J.P.jr (1985) Control of cytochrome P1-450 gene expression by dioxin, Science 227, 1499-1502.

    Article  Google Scholar 

  • Kaminsky, L.S., Kennedy, M.W., Adams, S.M., and Guengerich, F.P. (1991) Metabolism of dichlorobiphenyls by highly purified isozymes of rat liver cytochrome P450, Biochemistry 20, 7379-7384.

    Article  Google Scholar 

  • Kannan, K., Tanabe, S., Borrell, A., Aguilar, A., Focardi, S., and Tatsukawa, R. (1993) Isomer-specific analysis and toxic evaluation of polychlorinated biphenyls in striped dolphins affected by an epizootic in the Western Mediterranean Sea, Arch. Environ. Contam. Toxicol. 25, 227- 233.

    Article  CAS  Google Scholar 

  • Kavlock, R.J., Daston, G.P., De Rosa, C., Fenner-Crisp, P., Gray, L.E., Kaattari, S., Lucier, G., Luster, M., Mac, M.J., Maczka, C., Miller, R., Moore, J., Rolland, R., Scott, G., Sheehan, D.M., Sinks, T., and Tilson, H.A. (1996) Research needs for the risk assessment of health and environmental effects of endocrine disrupters: A report of the U.S. EPA sponsored workshop, Environ. Health Perspect. 104, 715-740.

    Article  Google Scholar 

  • Kay, D.P., Blankenship, A.L., Coady, K.K., Neigh, A.M., Zwiernik, M.J., Millsap, S.D., Strause, K., Park, C., Bradley, P., Newsted, J.L., Jones, P.D., and Giesy, J.P. (2005) Differential accumulation of polychlorinated biphenyl congeners in the aquatic food web at the Kalamazoo river superfund site, Michigan, Environ. Sci. Tech. 39, 5964-5974.

    Article  CAS  Google Scholar 

  • Korach, K.S., Sarver, P., Chae, K., McLachlan, J.A., and McKinney, J.D. (1987) Estrogen receptor-binding activity of polychorinated hydroxybiphenyls: conformationally restricted structural probes, Mol. Pharmacol. 33, 120-126.

    Google Scholar 

  • Kramer, V.J, and Giesy, J.P. (1999) Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships, Sci Total Environ. 233, 141-61.

    Article  CAS  Google Scholar 

  • Krishnan, V., and Safe, S. (1993) Polychlorinated biphenyls (PCBs), dibenzopdioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF7 human breast cancer cells: quantitative structureactivity relationships, Toxic Appl. Pharmacol. 120, 5561.

    Google Scholar 

  • Kubiak, T.J., Harris, H.J., Smith, L.M., Schwartz, T.R., Stalling, D.L., Trick, J.A., Sileo, L., Docherty, D.E., and Erdman, T.C. (1989) Microcontaminants and reproductive empairment of the Forster’s tern on Green Bay, Lake Michigan-1983, Archives Environ. Contam.Toxicol. 18, 706-727.

    Article  CAS  Google Scholar 

  • Kuriyama, S.N., Talsness, C.E., Grote K., and Chahoud, I. (2005) Developmental Exposure to Low Dose PBDE 99: 1–Effects on Male Fertility and Neurobehavior in Rat Offspring, Environ. Health erspect. 113, 149-154.

    CAS  Google Scholar 

  • Leatherland, J.F. and Sonstegard, R.A. (1982) Bioaccumulation of organochlorines by yearling coho salmon (Oncorhynchus kisutch Walbaum) fed diets containing Great Lakes coho salmon, and the pathophysiological responses of the recipients, Com. Biochem. Physiol. 72C, 91-99.

    Article  CAS  Google Scholar 

  • Marcus, M. and Tolbert, P. (2002) 2002 Progress Report: The Michigan PBB Cohort 20 Years Later Endocrine Disruption? 2002 Progress Report of the US-EPA project R825300 (http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/137/report/2002).

    Google Scholar 

  • Mocarelli, P., Gerthoux, P.M., Ferrari, E., Petterson, D.G., Kieszak, S.M., Brambilla, P., Vincoli, N., Signorini, S., Tramacere, P., Carreri, V., Sampson, E.J., Turner, W.E., and Needham, L.L. (2000) Paternal concentrations of dioxin and sex ratio of offspring, Lancet 355, 1858-1863.

    Article  CAS  Google Scholar 

  • Mocarelli, P. (2004) Dioxin health effects on humans twentyeight years after the “seveso” accident. International Symposium on Environmental Endocrine Disrupters 2004, p. 40.

    Google Scholar 

  • Morrison PA, Leatherland JF and Sonstegard, R.A. (1985) Plasma cortisol and sex steroid levels in Great Lakes coho salmon (Oncorhynchus kisutch Walbum) in relation to fecundity and egg survival, Comparative Biochem. Physiol. 80A, 61-68.

    Article  CAS  Google Scholar 

  • Moshammer, H., and Neuberger, M. (2000) Sex ratio in the children of the Austrian chloracne cohort. Lancet 356, 1271-1272.

    Article  CAS  Google Scholar 

  • Nakata, H., Kannan, K., Jing, L., Thomas, N., Tanabe, S., and Giesy, J.P. (1998) Accumulation pattern of organochlorine pesticides and polychlorinated biphenyls in southern sea otters (Enhydra lutris nereis) found stranded along coastal California, USA, Environ Pollution. 103, 45-53.

    Article  CAS  Google Scholar 

  • Parkinson, A., and Safe, S. (1987) Mammalian biologic and toxic effects of PCBs, In S. Safe and O. Hutzinger (eds), Polychlorinated biphenyls (PCBs): mammalian and environmental toxicology, Environmental Toxin Series vol. 1. Springer-Verlag, Heidelberg, pp. 49-75.

    Google Scholar 

  • Richthoff, J., Rylander, L., Jonsson, B.A., Akesson, H., Nilsson-Ehle, P., Stridsberg, M., and Giwercman, A. (2003) Serum levels of 2,2’,4,4’,5,5’-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population, Environ. Health Perspect. 111, 409-413.

    Article  CAS  Google Scholar 

  • Rignell-Hydbom, L., Rylander, A., Giwercman, B.A.G., Jönsson, P., Nilsson-Ehle, and Hagmar, L. (2004) Exposure to CB-153 and p,p’-DDE and male reproductive function. Hum. Reprod. 19, 2066 - 2075.

    Article  CAS  Google Scholar 

  • Rignell-Hydbon, A., Rylander, L., Giwercman, A., Jönsson, B., Lindh, C., Eleuteri, P., Rescia, M., Cordelli, E., Spano, M., and Hagmar, L. (2005) Exposure to PCBs and p,p’-DDE and human sperm chromatin integrity, Environ. Health Perspect. 113, 175-180.

    Article  CAS  Google Scholar 

  • Rories, C., and Spelsberg, T.C. (1989) Ovarian steroid action on gene expression: mechanisms and models, Annual Review Physiol. 51, 653-681.

    Article  CAS  Google Scholar 

  • Rozati, R., Reddy, P.P., Reddanna, P., and Mujaba, R. (2002). Role of environmental estrogens in the deterioration of male factor fertility, Fertil. Steril. 78, 1187-1194.

    Article  Google Scholar 

  • Safe, S. (1984) Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology and mechanism of action, Critical Review Toxicol. 13, 319-395.

    CAS  Google Scholar 

  • Safe, S., Bandiera, S., Sawyer, T., Robertson, L., Safe, L., Parkinson, A., Thomas, P.E., Ryan, D.E., Reik, L.M., Levin, V., Denomme, M., and Fujita, T. ( 1985) PCBs: structure-function relationship and mechanism of action, Environ. Health Perspect. 60, 47-56.

    Article  CAS  Google Scholar 

  • Safe, S. (1990) Polychorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds: environmental and mechanistic considerations which support the development of Toxic Equivalency Factors (TEFs), Cri. Rev. Toxicol. 21, 51-88.

    CAS  Google Scholar 

  • Safe, S. (1992) Toxicology, structure-function relationship and human and environmental health impacts of polychlorinated biphenyls: progress and problems, Environ. Health Perspect. 100, 259-268.

    Article  Google Scholar 

  • Safe, S. (2001) Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol. Lett. 120, 1–7.

    Article  CAS  Google Scholar 

  • Safe, S., and McDougal, A. (2002) Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). Int. J. Oncol. 20, 1123-1128.

    CAS  Google Scholar 

  • Schuppe, H. C., Wieneke, P., Fritsche, E., Donat, S., Köhn, F-M., and Abel, J. (2000) Xenobiotic metabolism, genetic polymorphisms and male infertility, Andrologia 32, 255–262.

    Article  CAS  Google Scholar 

  • Schure, A.F.H., Larssin, P., Merilä, J., and Jönsson, K.I. (2002) Latitudinal fractionation of polyhrominated diphenyl ethers and polychlorinated biphenyls in frogs in (Rana temporaria), Environ. Sci. Tech. 36, 5057-5061.

    Article  CAS  Google Scholar 

  • Sharpe, R.M. (2003) Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters, Int. J. Androl. 26, 2-15.

    Article  CAS  Google Scholar 

  • Silkworth, J.B., and Brown, J.F. (1996) Evaluating the Impact of Exposure to EnvironmentalContaminants on Human Health, Clin. Chem. 42, 1345-1349.

    CAS  Google Scholar 

  • Skakkebæk, N.E., Rajpert-De Meyts, E., and Main, K.M. (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects: Opinion, Hum. Reprod. 5, 972-978.

    Article  Google Scholar 

  • Soto, A.M., Justicia, H., Wray, J.W., and Sonnenschein, C. (1991) p-nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene, Environ. Health Perspect. 92, 167-173.

    Article  CAS  Google Scholar 

  • Soto, A.M., Lin, T., Justicia, H., Silvia, R., and Sonnenschein, C. (1992) An "in culture" bioassay to assess the estrogenicity of xenobiotics (E-SCREEN), In T. Colborn and C. Clement (eds.) Chemically induced alterations in sexual and functional development: the wildlife/human connection, Princeton, NJ: Princeton Scientific Publishing, 295-309.

    Google Scholar 

  • Subramanian, A., Tanabe, S., Tatsukawa, R., Saito, S., and Miyazaki, N. ( 1987) Reduction in the testosterone levels by PCBs and DDE in Dall’s porpoises of northwestern North Pacific, Marine Poll. Bull. 18, 643-646.

    Article  CAS  Google Scholar 

  • Takasugi, N., and Bern, H.A. (1988) Introduction: abnormal genital tract development in mammals following early exposure to sex hormones, In T. Mori and H. Nagasawa (eds) Toxicity of hormones in perinatal life, Boca Raton, FL: CRC Press, 1-7.

    Google Scholar 

  • Tanabe, S., Kannan, N., Subramanian, An., Watanabe, S., and Tatsukawa, R. ( 1987) Highly toxic coplanar PCBs: occurrence, source, persistency and toxic implications to wildlife and humans, Environ. Pollution. 47, 147-163.

    Article  CAS  Google Scholar 

  • Tanabe, S., Kannan, N., Wakimoto, T., and Tatsukawa, R. (1989) Isomer-specific determination and toxic evaluation of potentially hazardous coplanar PCBs, dibenzofurans and dioxins in the tissues of "Yusho" PCB poisoning victim and in the causal oil, Toxicol. Environ. Chem. 24, 215-231.

    Article  CAS  Google Scholar 

  • Tiemessen, C.H., Evers, J.L., and Bots, R.S. (1996) Tight-fitting underwear and sperm quality, Lancet 347, 1844-1845.

    Article  CAS  Google Scholar 

  • Tiido, T., Rygnell-Hydbom, A., Jönsson, B., Lundberg Giwercman, Y., Rylander, L., Hagmar, L. and Giwercman, A. (2005) Exposure to persistent organochlorine pollutants associates with human sperm Y:X chromosom ratio, Hum. Reprod. 20, 1903 – 1909.

    Article  CAS  Google Scholar 

  • Tillitt, D.E., Ankley, G.T., Giesy, J.P., Ludwig, J.P., Kurita-Matsuba, H., Weseloh, D.V., Ross, P.S., Bishop, C.A., Sileo, L., Stromborg, K.L., Larson, and Kubiak, T.J. (1992) Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the Great Lakes, Environ. Toxicol. Chem. 11, 1281-1288.

    CAS  Google Scholar 

  • Tillitt, D.E., G.T. Ankley, D.A. Verbrugge, J.P. Giesy, J.P. Ludwig, and Kubiak, T.J. (1991) H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbirds from the Great Lakes, Arch. Environ. Contam. Toxicol. 21, 91-101.

    Article  CAS  Google Scholar 

  • Toppari, J., Larsen, J.C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette Jr., L.J., Jégou, B., Jensen, T.K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J.A., Meyer, O., Müller, J., Meyts E.R.D., Scheike, T., Sharpe, R., Sumpter, J., and Skakkebæk, N.E. (1996) Male Reproductive Health and Environmental Xenoestrogens, Environ. Health Perspect. 104, 741.

    Article  CAS  Google Scholar 

  • Van den Berg, M., Birnbaum, L., Bosveld, A.T.C., Brunstom, B., Cook, P., Feeley, M., Giesy, J.P., Hanberg, A., Hasegawa, R., Kennedy, S.W., Kubiak, T., Larsen, J.C., van Leeuwen, F.X., Liem, A.K., Nolt, C., Peterson, R.E., Poellinger, L., Safe, S., Schrenk, D., Tillitt, D., Tysklind, M., Younes, M., Waern, F., and Zacharewski, T. (1998) Toxic Equivalents Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife, Environ. Health Perspect. 106, 775-788.

    Article  Google Scholar 

  • Voorspoels, S., Covaci, A., and Schepens, P. (2003) Polybrominated diphenyl ethers in marine species from the Belgian North Sea and the Western Scheidt Estuary: Levels, profiles, and distribution, Environ. Sci. Tech. 37, 4348-4357.

    Article  CAS  Google Scholar 

  • Wania, F., and Mackay, D. (1993) Global fractionation and cold condensation of low volatility organochlorine compounds in polar-regions, Ambio 22, 10-18.

    Google Scholar 

  • Wormke, M., Stoner, M., Saville, B., Walker, K., Abdelrahim, M., Burghardt R. and Safe, S. (2003) The Aryl Hydrocarbon Receptor mediated degradation of estrogen receptor through activation of proteostomases. Mol. Cell. Biol. 23, 1843-1855.

    Article  CAS  Google Scholar 

  • WHO - World Health Organisation (1999) Dioxins and their effects on human health, Fact Sheet no. 225, June 1999, at http://www.who.int/inf-fs/en/fact225.html.

    Google Scholar 

  • Yamashita, N., Kannan, K., Imagawa, T., Miyazaki, A., and Giesy, J.P. (2000) Concentrations and profiles of polychlorinated naphthalene congeners in eighteen technical polychlorinated biphenyl preparations, Environ. Sci. Tech. 34, 4236-4241.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Scienze Ambientali “G. Sarfatti”, Universitá degli Studi di Siena, via Mattioli, 4I-53100, Siena, Italy

    S. Corsolini

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  1. S. Corsolini
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  1. Medical School, Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece

    P. Nicolopoulou-Stamati

  2. Human Ecology Department, Vrije Universiteit Brussel, Brussels, Belgium

    L. Hens

  3. Bioimaging Research Group, Centre for Molecular Biosciences, University of Ulster, Coleraine, United Kingdom

    C.V. Howard

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Corsolini, S. (2007). Non-Pesticide Endocrine Disrupters And Reproductive Health. In: Nicolopoulou-Stamati, P., Hens, L., Howard, C. (eds) Reproductive Health and the Environment. Environmental Science and Technology Library, vol 22. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4829-7_8

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