Summary
The reproductive process is markedly affected by the environment. Toxic substances in the physical ecosystem, along with biological, social, cultural, and economical aspects of exposed populations, are factors that interact with each other, making the study of the effects of environmental variables on reproduction quite complex. Despite the difficulties in approaching the problem, the amount of available evidence supporting the concept that environmental contamination represents a risk factor to fertility steadily increases. In some circumstances, it is possible to identify precisely the toxic agent responsible for fertility impairment, as in the case of heavy metals. In other cases, the adverse effects are the result of exposure to complex mixtures, such as wood stoves, automotive and industrial emissions, and several classes of endocrine disrupting substances. The mechanisms responsible for environmental-dependent impairment of fertility are not fully identified, but some basic pathways can be presented: direct toxicity, induction of mutations, oxidative stress and endocrine disruption. Although in some cases the risk excess is small, there are toxic agents - such as air pollutants and contaminants of public water affecting millions of people, increasing the risk attributed to these diffuse environmental threats.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Acacio, B., Gottfried, T., Israel, R., and Sokol, R. (2000) Evaluation of a large cohort of men presenting for a screening semen analysis, Fertil. Steril. 73, 595-597.
Adamopolulos, D., Pappa, A., Nicopoulou, S., Andreous, E., Karamertzanis, M., Michopoulos, J., Deligiani, V., and Simou, M. (1996) Seminal volume and total sperm number trends in men attending subfertility clinics in the greater Athens area during the period 1977-1993, Hum. Reprod. 11, 1936-1941.
Arbuckle, T.E., Lin, Z., and Mery, L.S. (2001) An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population, Environ. Health. Perspect. 109, 851-857.
Aschengrau, A., Zierler, S., and Cohen, A. (1993) Quantity of community drinking water and the occurrence of late adverse pregnancy outcomes, Arch. Environ. Health. 48, 105-113.
Auger, J., Kunstmann, J., Czyglik, F., and Jouannet, P. (1995) Decline in semen quality among fertile men in Paris during the past 20 years,New England J. Med. 332, 281-285.
Baranowska, I. (1995) Lead and cadmium in human placentas and maternal and neonatal blood (in a heavily polluted area) measured by graphite furnace atomic absorption spectrometry, Occup. Environ. Med. 52, 229-232.
Bellinger, D.C. (2005) Teratogen update: lead and pregnancy, Birth Defects Res. A. Clin. Mol. Teratol. 73, 409-420.
Bendvold, E. (1989) Semen quality in Norwegian men over a 20-year period, Intl.J. Fertil. 34, 401-404.
Bendvold, E., Gottlieb, C., Bygdeman, M., and Eneroth, P. (1991) Depressed semen quality in Swedish men from barren couples: A study over three decades, Arch. Androl. 26, 189-194.
Berger, T., Horner, C.M. (2003) In vivo exposure of female rats to toxicants may a.ect oocyte quality, Reprod. Toxicol. 17, 273-281.
Billotta, P., Guglielmo, R., and Steffe, M. (1999) Analysis of decline in seminal fluid in the Italian population during the past 15 years, Minerva. Ginecol. 51, 223-231.
Bonde, J., Kold-Jensen, T., Brixen-Larsen, S., Abell, A., Scheike, T., Hojllund, N., Kolstad, H., Ernst, E., Giwercman, A., Skakkebaek, N., Keiding, N., and Olsen, J. (1998) Year of birth and sperm count in 10 Danish occupational studies, Scand. J. Work. Environ. Health. 24, 407-413.
Borgeest, C., Greenfeld, C., Tomic, D., and Flaws, J.A. (2002) The effects of endocrine disrupting chemicals on the ovary, Front. Biosci. 7, 1941-1948.
Bostofte, E., Serup, J., and Rebbe, H. (1983) Has the fertility of Danish men declined through the years in terms of semen quality? A comparison of semen qualities between 1952 and 1972, Intl. J. Fertil. 28, 91-95.
Bujan, L., Mansat, A., Pontonnier, F., and Mieusset, R. (1996) Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992, BMJ 312, 471-472.
Carlsen, E., Giwercman, A., Keidingm, N., and Skakkebaek, M. (1992) Evidence for decreasing quality of semen during past 50 years, BMJ 305, 609-613.
Cavieres, M.F. (2004) Pesticide exposure and reproductive and birth defects. Critical analysis of epidemiological and experimental evidence, Rev. Med. Chil. 132, 873-879.
Danielsson, B.R., Dencker, L., Lindgren, A., and Tjalve, H. (1984) Accumulation of toxic metals in male reproduction organs, Arch. Toxicol. Suppl. 7, 177-180.
Deane, M., Swan, S.H., Harris, J.A., Epstein, D.M., and Neutra, R.R. (1989) Adverse pregnancy outcomes in relation to water contamination, Santa Clara County, California, 1980-1981, Am. J. Epidemiol. 129, 894-904.
Dhooge, W., Stuyvaert, S., Kaufman, J.M., Koppe, G., Nele, V., Schoeters, G., van Larebeke, N., and Comhaire, F.(2001) Observations as to male fertility in the Flemish environment and health studies, Folia Histochem. Cytobiol. 39 2), 38-39.
Dodds, L., King, W., Woolcott, C., and Pole, J. (1999) Trihalomethanes in public water supplies and adverse birth outcomes, Epidemiology 10, 233-237.
Dummer, T.J., Dickinson, H.O., and Parker, L. (2003) Adverse pregnancy outcomes near landfill sites in Cumbria, northwest England, 1950-1993, Arch. Environ. Health. 58, 692-698.
Hruska, K.S., Furth, P.A., Seifer, D.B., Sharara, F.I., and Flaws, J.A. (2000) Environmental factors in infertility, Clin. Obstet. Gynecol. 43, 821-829.
Hwang, B.F., Magnus, P., and Jaakkola, J.J. (2002) Risk of specific birth defects in relation to chlorination and the amount onatural organic matter in the water supply, Am. J. Epidemiol. 156, 374-382.
Irvine, S., Cawood, E., Richardson, D., MacDonald, E., and Aitken, J. (1996) Evidence of deteriorating semen quality in the United Kingdom: Birth cohort study in 577 men in Scotland over 11 years, BMJ 31, 467-471.
James, W. (1980) Secular trend in reported sperm counts, Andrologia 12, 381-388.
James, W.H. (1990) The hypothesized hormonal control of human sex ratio at birth – an update, J. Theor. Biol. 143, 555–564.
James, W.H. (1994) Occupations associated with low offspring sex ratios, Am. J. Ind. Med. 25, 607-608.
Jarrell, J., Gocmen, A., Foster, W., Brant, R., Chan, S., and Sevcik, M. (1998) Evaluation of reproductive outcomes in women inadvertently exposed to hexachlorobenzene in southeastern Turkey in the 1950s, Reprod. Toxicol. 12, 469-476.
Jongbloet, P.H., Roeleveld, N., and Graeneword, M.M. (2002) Where the boys aren’t: dioxin and sex ratio , Environ. Health Perspect. 110, 1-3.
Klotz, J.B., and Pyrch, L.A. (1999) Neural tube defects and drinking water disinfection by-products, Epidemiology 10, 383–390.
Leto, S., and Frensilli, F.J. (1981) Changing parameters of donor semen , Fertil. Steril. 36, 766-770.
Longnecker, M.P., Rogan, W.J., and Lucier, G. (1997) The human health of DDT (dichlorodiphenyltrichloroethane) and PCBs (polychlorinated biphenyls) and an overview of organochlorines health, An. Rev. Public Health 18, 211-244.
Magnus, P., Jaakkola, J.J., Skrondal, A., Alexander, J., Becher, G., Krogh, T., and Dybing, E. (1999) Water chlorination and birth defects, Epidemiology 10, 513-517.
Maisonet, M., Correa, A., Misra, D., and Jaakkola, J. (2004) A review of the literature on the effects of ambient air pollution on fetal growth, Environ. Res. 95, 106-115.
Mayer, L.P., Pearsall, N.A., Christian, P.J., Devine, P.J., Payne, C.M., McCuskey, M.K., Marion, S.L., Sipes, I.G., and Hoyer, P.B. (2002) Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide, Reprod. Toxicol. 16, 775-781.
Menchini-Fabris, F., Rossi, O., Palego, O., Simi, S., and Turchi, P. (1996) Declining sperm counts in Italy during the past 20 years, Andrologia. 28, 304.
Menkveld, R., Van Zyl, Kotze, T., and Joubert, G. (1986) Possible changes in male fertility over a 15-year period, Arch. Androl. 17, 143-144.
Milham, S. (1993) Unusual sex ratio of births to carbon setter fathers, Am. J. Ind. Med. 23, 829-831.
Mocarelli, P., Brambilla, P., Gerthoux, P.M., Patterson, D.G. Jr., and Needham, L.L. (1996) Change in sex ratio with exposure to dioxin, Lancet 348, 409.
Mocarelli, P., Gerthoux, P.M., Ferrari, E., Patterson, D.G. Jr., Kieszak, S.M., Brambilla, P., Vincoli, N., Signorini, S., Tramacere, P., Carreri, V., Sampson, E.J., Turner, W.E., and Needham, L.L. (2000) Paternal concentrations of dioxin and sex ratio of offspring, Lancet 355, 1858 - 1863.
Mohallem, S.V., de Araujo Lobo, D.J., Pesquero, C.R., Assuncao, J.V., de Andre, P.A., Saldiva, P.H., and Dolhnikoff, M. (2005) Decreased fertility in mice exposed to environmental air pollution in the city of Sao Paulo, Environ. Res. 98, 196-202.
Multigner, L., and Oliva, A. Secular variations in sperm quality: fact or science fiction? Cad Saùde Pùblica. 18, 403-412.
Nelson, C., and Bunge, R. (1974) Semen analysis: Evidence for changing parameters of male fertility potential, Fertil. Steril. 25, 503-507.
Nieuwenhuijsen, M.J., Toledano, M.B., Eaton, N.E., Fawell, J., and Elliott, P. (2000) Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review, Occup. Environ. Med. 57, 73–85.
Osegbe, D., Segbe, D., Amaku, E., and Nnatu, S. (1986) Are changing semen parameters a universal phenomenon? Eur. Urol. 12, 164-168.
Osser, S., Liedholm, P., and Ranstam, J. (1984) Depressed semen quality: A study over two decades, Arch. Androl. 12, 113-116.
Paulsen, C., Berman, N., and Wang, C. (1996) Data from men in greater Seattle area reveals no downward trend in semen quality: Further evidence that deterioration of semen quality is not geographically uniform, Fertil. Steril. 65, 1015-1020.
Pereira, L.A., Loomis, D., Conceicao, G.M., Braga, A.L., Arcas, R.M., Kishi, H.S., Singer, J.M., Bohm, G.M., and Saldiva, P.H. (1998) Association between air pollution and intrauterine mortality in Sao Paulo, Brazil, Environ. Health Perspect. 106, 325-329.
Perera, F.P., Whyatt, R.M., Jedrychowski, W., Rauh, V., Manchester, D., Santella, R.M., and Ottman, R. (1998) Recent developments in molecular epidemiology: A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland, Am. J. Epidemiol. 147, 309-314.
Rasmussen, P., Erb, K., Westergaard, L., and Laursen, S. (1997) No evidence for decreasing semen quality in four birth cohorts of 1,055 Danish men born between 1950 and 1970, Fertil. Steril. 68, 1059-1064.
Rodamilans, M., Osaba, M.J., To-Figueras, J., Rivera Fillat, F., Marques, J.M., Perez, P., and Corbella, J. (1988) Lead toxicity on endocrine testicular function in an occupationally exposed population, Hum. Toxicol. 7, 125-128.
Ryan, J.J., Amirova, Z., and Carrier, G. (2002) Sex ratios of children of Russin pesticide producers exposed to dioxin , Environ. Health Perspect. 110, A699-A701.
Salazar-Garcia, F., Gallardo-Diaz, E., Ceron-Mireles, P., Loomis, D., and Borja-Aburto, V.H. (2004) Reproductive effects of occupational DDT exposure among male malaria control workers, Environ. Health Perspect. 112, 542-547.
San Sebastian, M., Armstrong, B., and Stephens, C. (2002) Outcomes of pregnancy among women living in the proximity of oil fields in the Amazon basin of Ecuador, Int. J. Occup. Environ. Health. 8, 312-319.
Savitz, D.A., Andrews, K.W., and Pastore, L.M. (1995) Drinking water and pregnancy outcome in central North Carolina: source, amount, and trihalomethane levels, Environ. Health Perspect. 103, 592-596.
Schlebusch, H., Wagner, U., van der Ven, H., al-Hasani, S., Diedrich, K., and Krebs, D. (1989) Polychlorinated biphenyls: the occurrence of the main congeners in follicular and sperm fluids, J. Clin. Chem. Clin. Biochem. 27, 663-667.
Silbergeld, E.K., and Patrick, T.E. (2005) Environmental exposures, toxicologic mechanisms, and adverse pregnancy outcomes, Am. J. Obstet. Gynecol. 192(5 Suppl), S11-21.
Sinawat, S. (2000) The environmental impact on male fertility, J. Med. Assoc. Thai. 83, 880-885.
Smith, K., Stultz, D., Jackson, J., and Steinberger, E. (1978) Evaluation of sperm counts and total sperm counts in 2543 men requesting vasectomy, Andrologia 10, 362-368.
Somers, C.M., McCarry, B.E., Malek, F., and Quinn, J.S. (2004) Reduction of particulate air pollution lowers the risk of heritable mutations in mice, Science 304, 1008-1010.
Somers, C.M., Yauk, C.L., White, P.A., Parfett, C.L., and Quinn, J.S. (2002) Air pollution induces heritable DNA mutations, PNAS 99, 15904-15907.
Sram, R.J., Binkova, B., Dejmek, J., and Bobak, M. (2005) Ambient air pollution and pregnancy outcomes: A review of the literature, Environ. Health Perspect. 113, 375-382.
Sram, R.J., Binkova, B., Rossner, P., Rubes, J., Topinka, J., and Dejmek, J. Adverse reproductive outcomes from exposure to environmental mutagens, Mutat. Res. 428, 203-215.
Tannenbaum, L.V., Bazar, M., Hawkins, M.S., Cornaby, B.W., Ferguson, E.A., Chantelle Carroll, L., and Ryan, P.F. (2003) Rodent sperm analysis in field-based ecological risk assessment: pilot study at Ravenna army ammunition plant, Ravenna, Ohio, Environ. Pollut. 123, 21-29.
Tiido, T., Rignell-Hydbom, A., Jonsson, B., Giwercman, Y.L., Rylander, L., Hagmar, L., and Giwercman, A. (2005) Exposure to persistent organochlorine pollutants associates with human sperm Y:X chromosome ratio, Hum. Reprod. 20, 1903-1909.
Topinka, J., Binkova, B., Mrackova, G., Stavkova, Z., Benes, I., Dejmek, J., Lenicek, J., and Sram, R.J. (1997) DNA adducts in human placenta as related to air pollution and to GSTM1 genotype, Mutat. Res. 390, 59-68.
Vierula, M., Niemi, M., Keiski, A., Saaranen, M., Saarikoski, S., and Suomne, J. (1996) High and unchanged sperm counts of Finnish men, Int J. Androl. 19, 11-17.
Waller, K., Swan, S.H., DeLorenze, G., and Hopkins, B. (1998) Trihalomethanes in drinking water and spontaneous abortion, Epidemiology 9, 134-140.
Weisskopf, M.G., Anderson, H.A., Hanrahan, L.P, and the Great Lakes Consortium (2003) Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study, Environ. Health Perspect. 2, 2.
Whorton, D, Haas, J.L., Trent, L., and Wong, O. (1994) Reproductive effects of sodium borates on male employees: birth rate assessment, Occup. Environ. Med. 51, 761-775.
Whorton, D., Krauss, S., Marshall, S., and Melby, T. (1977) Infertility in male pesticide workers, Lancet 2, 1259-1261.
Wrensch, M., Swan, S.H., Lipscomb, J., Epstein, D.M., Neutra, R.R., and Fenster, L. Spontaneous abortions and birth defects related to tap and bottled water use, San Jose, California, 1980-1985, Epidemiology 3, 98-103.
Xu, X., Cho, S.I., Sammel, M., You, L., Cui, S., Huang, Y., Ma, G., Padungtod, C., Pothier, L., Niu, T., Christiani, D., Smith, T., Ryan, L., and Wang, L. (1998) Association of petrochemical exposure with spontaneous abortion, Occup. Environ. Med. 55, 31-36.
Zorn, B., Virant-Klun, I., Verdenik, I., and Meden-Vrtovec, H. (1999) Semen quality changes among 2343 healthy Slovenian men included in an IVF-ET programme from 1983 to 1996, Int. J. Androl. 22, 178-183.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this chapter
Cite this chapter
Saldiva, P. (2007). Environment And Fertility. In: Nicolopoulou-Stamati, P., Hens, L., Howard, C. (eds) Reproductive Health and the Environment. Environmental Science and Technology Library, vol 22. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4829-7_3
Download citation
DOI: https://doi.org/10.1007/1-4020-4829-7_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-4828-9
Online ISBN: 978-1-4020-4829-6
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)