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Assessment Of Fertility And Other Health Impacts For Selected Pollutants In Flanders: Opportunities And Limitations

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Reproductive Health and the Environment

Part of the book series: Environmental Science and Technology Library ((ENST,volume 22))

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Summary

In Belgium, the available information regarding the distribution and effects of endocrine disrupters is fragmentary, and has shortcomings that inhibit purposeful prevention and a policy of emission reduction.

In this paper, the fertility impacts of a selected group of substances are subjected to a health risk assessment. This allows the fragmentary nature of the available information to be determined systematically and functionally. The risk assessment focuses on human health risk related to indirect exposures, and is established for five groups of pollutants: dioxins (halogenated hydrocarbon), atrazine (pesticide), bisphenol A (phenols), ethynylestradiol (synthetic hormone) and the tributyltin compounds (biocide/insecticide).

The potential risks of the exposure to these endocrine disrupters are assessed using a 4-step procedure that entails: (1) identification of hazards, (2) effect assessment, (3) exposure assessment and (4) risk characterisation. To assess the exposure in the third step, data for a worst-case scenario (with maximum concentrations in the different environmental compartments), average values and data for a minimum scenario (with minimum concentrations) are used. For each substance, a human daily intake is calculated. This takes into account the exposure to air, drinking water and food. Results show that dioxins offer the greatest cause for health concerns in Belgium. A minimal daily intake of 2.56 pg teq/kg bw was calculated, corresponding to a higher risk of endometriosis and a decrease in lymphocytes. Bisphenol A and ethynylestradiol occur in concentrations that might constitute a health hazard. However, more research on the effects of both substances is required before final conclusions can be drawn. Overall, this study shows that the current environmental exposure to dioxins and probably bisphenol A and ethynylestradiol entails health risks for the population.

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References

  • ATSDR - Agency for Toxic Substances and Disease Registry (2003) Toxicological profile. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA, On line: [http://www.atsdr.cdc.gov/toxpro2.html] [last accessed: 30/09/2005]

    Google Scholar 

  • Baroncelli, S., Karrer, D., and Turillazzi, P.G. (1990) Embryotoxic evaluation of bis (tributyltin)oxide (TBTO) in mice, Toxicol. Lett. 50, 257 – 262.

    Article  CAS  Google Scholar 

  • Belfroid, A.C., Van der Horst, A., Vethaak, A.D., Schaäfer, A.J., Rijs, G.B.J., Wegener, J., and Cofino, W.P. (1999) Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands, Total. Environ. Sci. 225, 101 – 108.

    Article  CAS  Google Scholar 

  • Belfroid, A., Van Velzen, M., Van der Horst, B., and Vethaak D. (2002) Occurrence of bisphenol A in surface water and uptake in fish: evaluation of field measurements, Chemosphere 49, 97-103.

    Article  CAS  Google Scholar 

  • BKH (2000) European Commission DG ENV: Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption - final report, BKH Consulting Engineers, Delft, the Netherlands.

    Google Scholar 

  • Bressa, G., Hinton, R.H., Price, S.C., Isbir, M., Ahmed, R.S., and Grasso, P. (1991) Immunotoxicity of tri-n-butyltin oxide (TBTO) and tri-n-butyltin chloride (TBTC) in the rat, J.Appl. Toxicol. 11, 397 – 402.

    Article  CAS  Google Scholar 

  • Bukovia, D., Dostal, M., and Hofmannova, V. (1992) Embryotoxicity of organotins, Reprod. Toxicol. 6, 178 – 179.

    Google Scholar 

  • Carthew, P., Edwards, R.E., and Dorman, B.M. (1992) The immunotoxicity of tributyltin oxide (TBTO) does not increase the susceptibility of rats to experimental respiratory infection, Hum. Exp. Toxicol. 11, 71 – 75.

    Article  CAS  Google Scholar 

  • Christensen, F.M. (1998) Pharmaceuticals in the environment – a human risk? Rel. Toxicol. Pharmacol. 28, 212 – 221.

    Article  CAS  Google Scholar 

  • Clark, D.E., Ivie, G.W., and Camp, B.J. (1981) Effects of dietary hexachlorobenzene on in vivo biotransformation, residue deposition, and elimination of certain xenobiotics by rats, J. Agric. Food Chem. 29, 600-608.

    Article  CAS  Google Scholar 

  • COM (1999) Community Strategy for endocrine disrupters. Annex 2: Existing community legislation covering environmental and human health aspects of chemicals. Assessment of their use in addressing endocrine disruption. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels, COM(1996)706 final, p. 24-31.

    Google Scholar 

  • COM (2001) Mededeling van de Commissie aan de Raad en het Europees Parlement over de tenuitvoerlegging van de communautaire strategie voor hormoonontregelaars– een groep stoffen waarvan vermoed wordt dat ze de hormoonhuishouding van mensen en in het wild levende dieren ontregelen (COM(1999)706), Brussel juni 2001.

    Google Scholar 

  • Cooper, R.L., Stoker, T.E., Goldman, J.M., Parrish, B., and Tyrey, L., (1996) Effect of atrazine on ovarian function in the rat, Reprod. Toxicol.10, 257-264.

    Article  CAS  Google Scholar 

  • Cooper, R.L., Stoker, T.E., McElroy, W.K., and Hein, J.F. (1998) Atrazine (ATR) disrupts the hypothalamic control of pituitary-ovarian function, Toxicologist 42, 160.

    Google Scholar 

  • Cooper, R.L., Stoker, T.E., Tyrey, L., Goldman, J.M., and McElroy, W.K. (2000) Atrazine disrupts the hypothalamic control of pituitary-ovarian function, Toxicol. Sci. 53, 297 – 307.

    Article  CAS  Google Scholar 

  • Crain, D.A., Guillete, L.J. Jr., Rooney, A.A., and Pickford, D.B. (1997) Alterations in steroidogenesis in alligators (Alligator mississippiensis) exposed naturally and experimentally to environmental contaminants, Environ. Health Perspect. 105, 528 – 533.

    Article  CAS  Google Scholar 

  • Crofton, K.M., Dean, K.F., and Boncek, V.M. (1989) Prenatal or postnatal exposure to bis(tri-nbutyltin)oxide in the rat: postnatal evalutaiton of teratology and behaviour, Toxicol. Appl. Pharmacol. 97, 113 – 123.

    Article  CAS  Google Scholar 

  • Danzo, B.J. (1998) The effects of environmental hormones on reproduction, Cell. Mol. Life. Sci. 54, 1249-1264.

    Article  CAS  Google Scholar 

  • Davis, A. (1987) Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests, Mutat. Res. 188, 65 – 95.

    Article  CAS  Google Scholar 

  • Degen, G.H., Janning, P., Wittsiepe, J., Upmeier, A., and Bolt, H.M. (2002) Integration of mechanistic data in the toxicological evaluation of endocrine modulators, Toxicol. Lett. 127, 225-237.

    Article  CAS  Google Scholar 

  • Dejonckheere, W., Steurbaut, W., Drieghe, S., Verstraeten, R., and Braeckman, H. (1996a) Pesticides residue concentration in the Belgian total diet, 1991 – 1993, J. AOAC. Int. 79, 520-528.

    CAS  Google Scholar 

  • Dejonckheere, W., Steurbaut, W., Drieghe, S., Verstraeten, R., and Braeckman, H. (1996b) Monitoring of pesticide residues in fresh vegetables, fruit and other selected food items in Belgium, 1991 – 1993, J. AOAC. Int. 79, 97-110.

    CAS  Google Scholar 

  • EC - European Commission (2003) Technical guidance document in support of Commission Directive 93/67/EEC on Risk assessment for new notified substances and Commission Regulation (EC) No 1488/94 on risk assessment for existing substances part I – IV, ECSC-EC-EAEC, Office for Official Publications of the European Communities, on line [http://ecb.jrc.it/] [last accessed: 30/09/2005]

    Google Scholar 

  • EPA - Environmental Protection Agency (2002) Environmental Protection Agency, on line [http://www.epa.gov/] [last accessed: 30/09/2005]

    Google Scholar 

  • Eskenazi, B., Warnet, M., Mocarelli, P., Samuels, S., Needham, L.L., Patterson, D.G. Jr., Lippman, S., Vercellini, P., Gerthoux, P.M., Brambilla, P., and Olive, D. (2002) Serum dioxin concentrations and menstrual cycle characteristics, Am. J. Epidemiol. 156, 383-392.

    Article  Google Scholar 

  • Farabollini, F., Porrini, S., Della Seta, D., Bianchi, F., and Dessi-Fulgheri, F. (2002) Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats, Environm. Health Perspect. 110, 409-413.

    CAS  Google Scholar 

  • Fernandez, M.F., Rivas, A., Pulgar, R., and Olea, N. (2001) Human exposure to endocrine disrupting chemicals: the case of bisphenols, In P. Nicolopoulou-Stamati, L. Hens, and C.V. Howard (eds) Endocrine disrupters, Environmental Health and Policies, Environmental Sciences Technology Library, Kluwer Academic Publishers, Dordrecht, Boston, London, 376 p.

    Google Scholar 

  • Foran, C.M., Peterson, B.N., and Benson, W.H. (2002) Transgenerational and developmental exposure of Japanese medaka (Oryzias latipes) to ethinylestradiol results in endocrine and reproductive differences in the response to ethinylestradiol as adults, Toxicol. Sci. 68, 389-402.

    Article  CAS  Google Scholar 

  • Gaudet, B.A.J. (2001) Risk assessments of dioxins: a comparative literature review, Master’s thesis, Vrije Universiteit Brussels, Belgium.

    Google Scholar 

  • Gojmerac, T., Kartal, B.,Curic, S., Zuric, M, Kusevic, S., and Cvetnic, Z. (1995) Serum biochemical changes associated with cystic ovarian degeneration in pigs after atrazine treatment, Toxicol. Lett. 85, 9 – 15.

    Article  Google Scholar 

  • Gojmerac, T., Uremovic, M., Uremovic, Z., Curic, S., and Bilandzic, N. (1999) Reproductive disturbance by an S-triazine herbicide in pigs, Acta. Vet. Hung. 47, 129-135.

    Article  CAS  Google Scholar 

  • Haighton, L.A., Hlywka, J.J., Doull, J., Kroes, R., Lynch, B.S., and Munro, I.C. (2002) An evaluation of the possible carcinogenicity of bisphenol A to humans, Rel. Toxicol. Pharmacol. 35, 238-254.

    Article  CAS  Google Scholar 

  • Hanze (1994) Chemicals with estrogen-like effect, Nordic Council of ministers, TemaNord 1996, Kopenhagen.

    Google Scholar 

  • Hens, L. (2001) Risk assessment of endocrine disrupters, In P. Nicolopoulou-Stamati, L. Hens, and C.V. Howard (eds) Endocrine disrupters, Environmental Health and Policies, Environmental Sciences Technology Library, Kluwer Academic Publishers, Dordrecht, p. 171 – 216.

    Google Scholar 

  • Hooghe, R.J., Devos, S., and Hooghe-Peters, E.L. (2000) Effects of selected herbicides on cytokine production in vitro, Life Sci. 66, 2519-2525.

    Article  CAS  Google Scholar 

  • IARC - International Agency for Research on Cancer (1997) International Agency for Research on Cancer Website, on line [http://www.iarc.fr] [last accessed: 30/09/2005]

    Google Scholar 

  • INSERM - Institut National de la Santé et de la Recherche Médicale (2000) Dioxines dans l’environnement, Quels risques pour la santé? Expertise collective. ISBN 2-85598-784-9. Les éditions Inserm, Paris.

    Google Scholar 

  • Karrer, D., Borncelli, S., and Turillazzi, P.G. (1995) Oral bis(tri-n-butyltin)oxide in pregnant mice. II. Alterations in haematological parameters, J. Toxicol. Environ. Health 46, 369 – 377.

    CAS  Google Scholar 

  • Kociba, R.J., Keyes, D.G., Beyer, J., Carreon, R., Wade, C., Dittenber, D., Kalnins, R., Frauson, L., Park, C., Barnard, S., Hummel, R., and Humiston, C. (1978) Results of the two year toxicity and oncolgenicity study of 2,3,7,8-tetracholorodibenzo-p-dioxin, Toxicol. Appl. Pharmacol. 46, 279 – 303.

    Article  CAS  Google Scholar 

  • Kohn, M.C., Sewall, C.H., Lucier, G.W., and Portier, C.J. (1996) A mechanistic model of effects of dioxin on thyroid hormones in the rat, Toxicol. Appl. Pharmacol. 136, 29 – 48.

    Article  CAS  Google Scholar 

  • Koopman-Esseboom, C., Morse, D.C., Weisglas-Kuperus, N., Lutkeschipholt, I.J., Van der Pauw, C.G., Tuinstra, L.G.M.T., Brouwer, A., and Sauer, P.J.J. (1994) Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants, Pediatr. Res. 36, 468-473.

    Article  CAS  Google Scholar 

  • Koppen, G., Covaci, A., Van Cleuvenbergen, R., Schepens, P., Winneke, G., Nelen, V., van Larebeke, N., Vlietinck, R., and Schoeters, G. (2002) Persistent organochlorine pollutants in human serum of 50 – 65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 1: Concentrations and regional differences, Chemosphere 48, 811- 825.

    Article  CAS  Google Scholar 

  • Lai, K.M., Scrimshaw, M.D., and Lester, J.N. (2002) Prediction of the bioaccumulation factors and body burden of natural and synthetic estrogens in aquatic organisms in the river systems, Total Environ. Sci. 289, 159-168.

    Article  CAS  Google Scholar 

  • Langston, W.J. (1996) Recent developments in TBT Ecotoxicology, Toxicol. Ecotoxicol. News 3, 179-187.

    CAS  Google Scholar 

  • Larsson, D.G.J., Adolfsson-Erici, M., Parkkonen, J., Pettersson, M., Berg, A.H., Olsson, P.E., and Förlin, L. (1999) Ethinyloestradiol – an undesired fish contraceptive? Aqua. Toxicol. 45, 91-97.

    Article  CAS  Google Scholar 

  • Leonards, P.E.G., Lohman, M., de Wit, M.M., Booy, G., Brandsma, S.H., and de Boer, J. (2000) Actuele situatie van gechloreerde dioxines, furanen en polychloorbifenylen in visserij-producten: Quick- en Full-scan, RIVO rapport nummer C034/00.

    Google Scholar 

  • Liem, A.K.D., van den Berg, R., Bremmer, H.J., Hesse, J.M., and Slooff, W. (1993) Integrated Criteria Documents Dioxins, RIVM, reportnr. 710401032, december 1993.

    Google Scholar 

  • Liem, A.K.D., Hemert, A.W. van, Marsman, J.A., Hertog, R.S. den, Hoogerbrugge, R., Hijman, W.C., Linders, S.H.M.A., and Zomer, G. (1997) Dioxinegehalten in geïmporteerde zuivelproducten, RIVM rapport 639 102019.

    Google Scholar 

  • Maier, W.E., and Herman, J.R. (2001) Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals, Rel. Toxicol. Pharmacol. 34, 53-61.

    Article  CAS  Google Scholar 

  • Majewski, A.R., Blanchfield, P.J., Palace, V.P., and Wautier, K. (2002) Waterborne 17α -ethynylestradiol affects aggressive behavior of male fathead minnows (Pimephales promelas) under artificial spawning conditions, Water Qual. Res. J. Canada. 37, 697-710.

    CAS  Google Scholar 

  • Markey, C.M., Michaelson, C.L., Sonnenschein, C., and Soto, A.M. (2001a) Alkylphenols and bisphenol A as environmental estrogens, In M. Metzler (ed) Endocrine disrupters part I – The handbook of environmental chemistry, Springer, Berlin, 209 p.

    Google Scholar 

  • Markey, C.M., Michaelson, C.L., Veson, E.C., Sonnenschein, C., and Soto, A.M. (2001b) The mouse uterotropicity assay: re-evaluation of its validity in assessing the estrogenicity of bisphenol A, Environ. Health Perspect. 109, 55-60.

    Article  CAS  Google Scholar 

  • Milman, H.A., Bosland, M.C., Walden, P.D., and Heinze, J.E. (2002) Evaluation of the adequacy of published studies of low-dose effects of bisphenol A on th erodent prostate for use in human risk assessment, Regul. Toxicol. Pharmacol. 35, 338 – 346.

    Article  CAS  Google Scholar 

  • MIRA-T (2001) Milieu-en Natuurrapport Vlaanderen, VMM, on line [http://www.vmm.be] [last accessed: 30/09/2005]

    Google Scholar 

  • Mocarelli, P., Brambilla, P., and Gerthoux, P.M. (1996) Change in sex ratio with exposure to dioxin, Lancet 348, 409.

    Article  CAS  Google Scholar 

  • Mocarelli, P., Gerthoux, P.M., and Ferrari, E. (2000) Paternal concentrations of dioxin and sex ratio of offspring, Lancet 355, 1858-1863.

    Article  CAS  Google Scholar 

  • Nativelle-Serpentini, C., Richard, S., Séralini, G.E., and Sourdaine, P. (2003) Aromatase activity modulator by lindane and bisphenol A in human placenta JEG-3 and transepten kidney E293 cells, In vitro Toxicol. Article in press.

    Google Scholar 

  • Poustka, J., Hajslova, J., and Holadova, K. (2000) Application of Various Techniques for Analysis of Bisphenol A, BADGE and BFDGE in Food, Institute of Chemical Technology in Prague.

    Google Scholar 

  • Quaghebuer, D., and De Wulf, E. (1999) Bestrijdingsmiddelen in het regenwater in Vlaanderen, rapport 1999, VMM.

    Google Scholar 

  • Rier, S.H., Martic, D.C., Bowman, R.E., Dmowski, W.P., and Becker, J.L. (1993) Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, Fundam. Appl. Toxicol. 21, 433 – 441.

    Article  CAS  Google Scholar 

  • Routledge, E.J., Sheahan, D., Desbrow, C., Brighty, G.C., Waldock, M., and Sumpter, J.P. (1998a) Identification of estrogenic chemicals in STW effluent. 2. In vivo responses in trout and roach, Environ. Sci. Technol. 32, 1559-1565.

    Article  CAS  Google Scholar 

  • Royar, J., Becher, H., and Chang-Claude, J. (2001) Low-dose oral contraceptives: protective effect on ovarian cancer risk, Int. J. Cancer. 95, 370-374.

    Article  CAS  Google Scholar 

  • Rubin, S.B., Murray, M.K., Damassa, D.A., King, J.C., and Soto, A.M. (2001) Perinatal exposure to low doses of bisphenol A affects body weight, patterns of oestrus cyclicity and plasma LH levels, Environ. Health Perspect. 109, 675-680.

    Article  CAS  Google Scholar 

  • Rudel, A.R., Melley, S.J., Geno, P.W., Sun, G., and Brody, J.G. (1998) Identification of alkylphenols and other estrogenic phenolic compounds in waste water, septage and ground water on Cape Cod, Massachusetts, Environ. Sci. Technol. 32, 861-869.

    Article  CAS  Google Scholar 

  • Sanderson, J.T., Seinen, W., Giesy, J.P., and van den Berg, M. (2000) 2-chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity, Toxicol. Sci. 54, 121 – 127.

    Article  CAS  Google Scholar 

  • Schantz, S.L., Levin, E.D., Bowman, R.E., Heironimus, M.P., and Laughlin, N.K. (1989) Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys, Neurotoxicol. Teratol. 11, 243 – 250.

    Article  CAS  Google Scholar 

  • SCF - Scientific Committee on Food (2000) Opinion of the Scientific Committee on the risk assessment of dioxin and dioxin-like PCBs in food, European Commission Health and Consumer Protection Directorate-General, SCF/CS/CNTM/DIOXIN/8Final, 23 Nobember 2000.

    Google Scholar 

  • Schroeder, R.E. (1981) A teratology study in rats with bis(tri-n-butyltin)oxide, unpublished report by Bio/dynamics, Inc. prepared for Elf Atochem. MRID No. 00137158, 92172005, 92172016. HED Doc. No. 003914, 004691, 010916.

    Google Scholar 

  • Schroeder, R.E. (1990) A two-generation reproduction study in rats with bis(tri-n-butyltin)oxide, unpublished report by Bio/dynamics, Inc. prepared for Shering AG and M&T Chemicals., Inc. MRID No. 416938-01.

    Google Scholar 

  • Segner, H., Caroll, K., Fenske, M., Janssen, C.R., Maack, G., Pascoe, D., Schäfers, C., Vandenbergh, G.F., Watts, M., and Wenzel, A. (2003) Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project, Ecotoxicol. Environ. Safe. 54, 302-314.

    Article  CAS  Google Scholar 

  • Smialowicz, R.J., Riddle, M.M., Rogers, R.R., Leubke, R.W., and Copeland, C.B. (1989) Immunotoxicity of tributyltin oxide in rats exposed as adults or pre-weanlings, Toxicology 57, 97 – 111.

    Article  CAS  Google Scholar 

  • Stevens, T.T., Breckenridge, C.B., Wetzel, L.T., Gillis, J.H., Luempert, L.G., and Eldridge, J.C. (1994) Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides, J. Toxicol. Environ. Health 43, 139 – 153.

    Article  CAS  Google Scholar 

  • Tavera-Mendoza, L., Ruby, S., Brousseau, P., Fournier, M., Cyr, D., and Marcogliese, D. (2002) Response of the amphibian tadpole (Xenopus laevis) to atrazine during sexual differentiation of the ovary, Environ. Toxicol. Chem. 21, 1264 – 1267.

    Article  CAS  Google Scholar 

  • Thayer, K.A., Ruhlen, R.L., Howdeshell, K.L., Buchanan, D.L., Cooke, P.S., Preziosi, D., Welshons, W.V., Haseman, J., and vom Saal, F.S. (2001) Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17 alpha-ethinyl oestradiol, APMIS 109, 278-286.

    Google Scholar 

  • Travis, C.C., and Hattemer–Frey, H.A. (1987) Human exposure to 2,3,7,8-TCDD, Chemosphere 16, 2331-2342.

    Article  CAS  Google Scholar 

  • Vandenbergh, G., Janssen, C., De Coen, W., Dhooge, W., and Comhaire, F. (2000). Verspreiding en effecten van endocrien verstorende stoffen in België, @wel6-Water, 7 p.

    Google Scholar 

  • Van Larebeke, N., Hens, L., Schepens, P., Covaci, A., Bayens, J., Everaert, K., Bernheim, J.L., Vlietinck, R., and De Poorter, G. (2001) The Belgian PCB and Dioxin Incident of January – June 1999: Exposure data and potential impact on health, Environ. Health Perspect. 109, 265-273.

    Article  Google Scholar 

  • Van Leeuwen, J.A., Waltner-Toews, D., Abernathy, T., Smit, B., and Shoukri, M. (1999) Associations between stomach cancer incidence and drinking water contamination with atrazine and nitrate in Ontario (Canada) agroecosystems, 1987 – 1991, Int. J. Epidemiol. 28, 836-840.

    Article  Google Scholar 

  • Van Loveren, H., Krtajnc, E.I., Rombout, P.J.A., Blommaert, F.A., and Vos, J.G. (1990) Effects of ozone, hexachlorobenzene and bis(tri-n-butyltin)oxide on natural killer activity in the rat lung, Toxicol. Appl. Pharmacol. 102, 21-33.

    Article  Google Scholar 

  • Vethaak, D., and Opperhuizen, A. (1996) Xeno-oestrogene stoffen in het aquatisch milieu in Nederland: een verkennende studie, rapport RIKZ (Rijksinstituut voor Kust en Zee), 96.015. Den Haag, Nederland, 73 p.

    Google Scholar 

  • Vethaak, A.D., Rijs, G.B.J., Schrap, S.M., Ruiter, H., Gerritsen, A., and Lahr, J. (2002) Estrogens and xeno-estrogens in the aquatic environment of the Netherlands, Occurrence, potency and biological effects, RIZA/RIKZ-report no. 20002.001, 266 p.

    Google Scholar 

  • Verdier, F., Virat, M., Scheiwnfurt, H., and Descotes, J. (1991) Immunotoxicity of bis(tri-nbutyltin)oxide in the rat, J. Toxicol. Environ. Health 32, 307 – 319.

    CAS  Google Scholar 

  • VMM (2002) Jaarrapport: Waterkwaliteit – Lozingen in het water 2001, Vlaamse Milieumaatschappij, Erembodegem.

    Google Scholar 

  • Völkel, W., Colnot, T., Csanady, G.A., Filser, J.G., and Dekant, W. (2002) Metabolism and kinetics of bisphenol A in humans at low doses following oral administration, Chem. Resear. Toxicol. 15, 1281-1287.

    Article  CAS  Google Scholar 

  • Vom Saal, F.S., Cooke, P.S., Buchanan, D.L., Palanza, P., Thayer, K.A., Nagel, S.C., Parmigiana, S., and Welshons, W.V. (1998) A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behaviour, Toxicol. Ind. Health. 14, 239-260.

    Google Scholar 

  • Vos, J.G., DeKlerk, A., Krajnc, E.I., Van Loveren, V., and Rozing, J. (1990) Immunotoxicity of bis(tri-n-butyltin)oxide in the rat: effects on thymus-dependent immunity and on non-specific resistance following long-term exposure in young versus aged rats, Toxicol. Appl. Pharmacol. 105, 144 – 155.

    Article  CAS  Google Scholar 

  • Vrijens, B., De Henauw, S., Dewettinck, K., Talloen, W., Goeyens, L., De Backer, G., and Willems, J.L. (2002) Probabilistic intake assessment and body burden estimation of dioxin-like substances in background conditions and during a short food contamination episode, Food. Add. Contam. 19, 687 – 700.

    Article  CAS  Google Scholar 

  • Wenzel, A., Küchler, T., Henschel, K.P., Schnaak, W., Diedrich, M., and Müller, J. (1998) Konzentrationen oestrogen wirkender Substanzen in Umwelfmedien, report no. 216 02 01111, by order of Federal Environmental Agency, Berlin, Germany.

    Google Scholar 

  • Watson, D. (2001) Survey of bisphenols in canned foods, Food Standards Agency 13(1), on line [http://www.foodstandards.gov.uk/science/surveillance/fsis-2001/bisphenols] [last accessed: 30/09/2005]

    Google Scholar 

  • Yamamoto, T., and Yasuhara, A. (1999) Quantities of bisphenol A leached from plastic waste samples, Chemosphere 38, 2569-2576.

    Article  CAS  Google Scholar 

  • Yamasaki, K., Sawaki, M., Noda, S., Imatanaka, N., and Takatsuki, M. (2002) Subacute oral toxicity study of ethinylestradiol and bisphenol A, based on the draft protocol for the ‘Enhanced OECD Test Guideline no. 407’, Arch. Toxicol. 76, 65-74.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Human Ecology Department, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium

    J. De Wit, A. Verspecht & L. Hens

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  1. J. De Wit
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  2. A. Verspecht
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  3. L. Hens
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Editors and Affiliations

  1. Medical School, Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece

    P. Nicolopoulou-Stamati

  2. Human Ecology Department, Vrije Universiteit Brussel, Brussels, Belgium

    L. Hens

  3. Bioimaging Research Group, Centre for Molecular Biosciences, University of Ulster, Coleraine, United Kingdom

    C.V. Howard

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© 2007 Springer

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De Wit, J., Verspecht, A., Hens, L. (2007). Assessment Of Fertility And Other Health Impacts For Selected Pollutants In Flanders: Opportunities And Limitations . In: Nicolopoulou-Stamati, P., Hens, L., Howard, C. (eds) Reproductive Health and the Environment. Environmental Science and Technology Library, vol 22. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4829-7_12

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