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Structural Principles of Ras Interaction with Regulators and Effectors

  • Chapter
RAS Family GTPases

Part of the book series: Proteins and Cell Regulation ((PROR,volume 4))

Abstract

In the past years, a considerable progress has been made in the fundamental understanding of the functions and underlying mechanisms of the proto-oncogen Ras. Comprehensive structural studies resulted in determination of more than 50 structures, which provided a deep insight into the three-dimensional folds, the consequences of ligand binding and hydrolysis, the principles of regulation and the specificity of effector binding. This chapter is concerned with the structural aspects of a molecular switch as a pivotal component of the signal transduction machinery

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  1. Department Structural Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany

    Dennis Fiegen, Radovan Dvorsky & Mohammad Reza Ahmadian

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  1. Dennis Fiegen
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  2. Radovan Dvorsky
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  1. University of North Carolina at Chapel Hill, U.S.A

    Channing Der

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Fiegen, D., Dvorsky, R., Ahmadian, M.R. (2006). Structural Principles of Ras Interaction with Regulators and Effectors. In: Der, C. (eds) RAS Family GTPases. Proteins and Cell Regulation, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4708-8_3

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