Abstract
In eukaryotic cells, tetrapyrrole intermediates and end-products play a crucial role as intra-organellar regulators within the chloroplast or mitochondrion, which are sites of heme and chlorophyll biosynthesis, by exerting a feedback control on the enzyme activities of their own biosynthetic pathway. It is proposed that some tetrapyrrole metabolites also act as inter-organellar signals communicating with the nucleus to coordinate nuclear and organellar activities by regulating nuclear gene expression in response to the physiological and developmental state of the mitochondrion or plastid.
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Beck, C.F., Grimm, B. (2006). Involvement of Tetrapyrroles in Cellular Regulation. In: Grimm, B., Porra, R.J., Rüdiger, W., Scheer, H. (eds) Chlorophylls and Bacteriochlorophylls. Advances in Photosynthesis and Respiration, vol 25. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4516-6_16
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