Skip to main content
SpringerLink
Log in

CELL AQUA MEDIUM AS A PRIMARY TARGET FOR THE EFFECT OF ELECTROMAGNETIC FIELDS

  • Conference paper
BIOELECTROMAGNETICS Current Concepts

Part of the book series: NATO Security Through Science Series ((NASTB))

Abstract

Due to exponentially increasing use of electromagnetic field (EMF) emitting technology, human exposure to EMF becomes more and more common and complicated. Therefore, the study of the biological effects of EMF is of crucial importance from the aspect of public health. At present the specific (non thermal) biological effect of EMF can be considered as a proven fact, however the question, how such low-energy EMF radiation could modulate the functional activity of cell and organism, still remains unanswered. A numerous hypotheses for molecular mechanisms of the biological effect of EMF have been proposed, but none have provided a reliable and comprehensive explanation of the experimental findings. The oldest hypothesis is that EMFinduced structural changes of cell bathing solution could serve as a primary target for the biological effect of EMF. As water is the main component of the medium where the major part of biochemical reactions are taking place, it is easy to predict that a slight changes of physico-chemical properties of both intracellular and extra cellular water could change the metabolic activity of cells and organisms. In the present chapter based on literature and our own results we are going to demonstrate the reliability of this hypothesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adey, W. R., 1981, Tissue interactions with non-ionizing electromagnetic field, Physiol. Rev., 61: 435–514.

    PubMed  CAS  Google Scholar 

  • Alekseev, S.I. and Ziskin, M.C., 2001, Millimeter wave Power Density in Aqueous Biological Samples. Bioelectromagnetics, 22: 288–291.

    Article  PubMed  CAS  Google Scholar 

  • Amyan, A.M., Ayrapetyan, S.N., 2004, On the Modulation Effect of Pulsing and Static Magnetic Fields and Mechanical Vibrations on Barley Seed Hydration. Physiological Chemistry & Physics and Medical NMR, 36: 69–84.

    Google Scholar 

  • Arvanov, V.L., Salanki, J., Ayrapetyan, S.N., 1984, Modification of Acetylcholine Sensitivity of Neuronal Membrane by Presynaptic Stimulation. Gen.Physiol.Biophys., 3: 483–488.

    PubMed  CAS  Google Scholar 

  • Avetisian, T.O., Gharibova, L.S., Ayrapetyan, S.N., 1995, The effect SMF on 3H-thymidine incorporation into rat spleen cells. Biol. J. of Armenia, 3: 19–22.

    Google Scholar 

  • Ayrapetyan, S. N., 1969, Metabolically-dependent part of membrane potential and electrode properties of giant neuron membrane of mollusk, Biofizika, 14: 1027–1031 (in Russian).

    Google Scholar 

  • Ayrapetyan, S.N., 1980, On The Physiological Significant of Pump Induced Cell Volume Changes. Adv. Physiol.Sci., 23: 67–82.

    Google Scholar 

  • Ayrapetyan, S. N. and Arvanov, V. L., 1979, On the mechanism of the electrogenic sodium pump dependence of membrane chemosensitivity. Comp. Biochem. Physiol. 64A: 601–604.

    Article  CAS  Google Scholar 

  • Ayrapetyan, S. N. and Suleymanyan, M. A., 1979, On the pump-induced cell volume changes. Comp. Biochem. Physiol. 64a: 571–575.

    Article  CAS  Google Scholar 

  • Ayrapetyan, S.N., Arvanov, V.L., Maginyan, S.B., Azatian, K.V., 1985, Further Study of The Correlation Between Na- Pump Activity and Membrane Chemosensitivity. Cell. Molec. Neurobiol., 5:231–243.

    Article  PubMed  CAS  Google Scholar 

  • Ayrapetyan, S.N., Arvanov, V.L., 1988, The Metabolic Regulation of Membrane Chemosensitivity, in: Neurobiology of Invertebrates, Salanki ed., Budapest, 36, 669–684.

    Google Scholar 

  • Ayrapetyan S.N. and Carpenter, D.O. 1991. Very low concentration of acetylcholine and GABA modulate transmitter responses. Membrane and Cellular Biophysics and Biochemistry, NeuroReport 2, 563–565.

    CAS  Google Scholar 

  • Ayrapetyan, S. N., Grigorian, K. V., Avanesian, A. S., Stamboltsian, K.V., 1994a, Bioelectromagnetics, 5:133–142.

    Article  Google Scholar 

  • Ayrapetyan, S.N., Avanesian, A.S., Avetisian, T., Majinian, S., 1994b, in: Biological Effects of Electrical and Magnetic Fields, D. Carpenter & S. Ayrapetyan, eds., Vol. 1 Academic Press, New York, pp: 181–192.

    Google Scholar 

  • Ayrapetyan, S.N., Hunanian, A.Sh., Hakobyan, S.N., 2004, The 4 Hz EMF -treated physiological solution depress Ach-induced neuromembrane current. Bioelectromagnetics, 25(5):397–399.

    Article  PubMed  CAS  Google Scholar 

  • Ayrapetyan, G.S., Papanyan, A.V., Hayrapetyan, H. V., Ayrapetyan, S.N., 2005, The Metabolic Pathway of Magnetic Field-induced Relaxing Effect on Heart Muscle. Bioelectromagnetics. (in press).

    Google Scholar 

  • Azatian, K.V., White, A.R., Walker, R.J., Ayrapetyan, S.N., 1998, Cellular and Molecular Mechanisms of Nitric Oxide-Induced Heart Muscle Relaxation. Gen. Pharmac., 30: 543–553.

    Article  CAS  Google Scholar 

  • Barnothy, M.F., 1969, in: Biological effects in magnetic fields, Vol. II, Plenum Press, New York.

    Google Scholar 

  • Blackman, C.F., Benane, S.G., Kinney, L.S., Jones, W.T., House, D.E., 1982, Effect of ELF Fields on calcium-ion efflux from brain tissue in vitro. Radiat. Res. 92: 510–520.

    Article  PubMed  CAS  Google Scholar 

  • Carpenter, D. and Alving, B., 1969, A contribution of electrogenic Na pump to membrane potential in Aplysia neurons. G. Physiology, 52: 1–21.

    Article  Google Scholar 

  • Cooke, K. R., 1978, Effect of ouabain and K-free medium on cellular volume regulation in rat renal cortical slices. J. Physiol. 279: 375–384.

    PubMed  CAS  Google Scholar 

  • Danielyan, A.A., Mirakyan, M.M., Grigoryan, G.Y., Ayrapetian, S.N., 1999, The Static Magnetic Field on Ouabain H3 Binding by Cancer Tissue, Physio. Chem.and Physics and Med. NMR, 31 (2):139–144.

    CAS  Google Scholar 

  • D’Arsonval, A., 1882, Effect of a powerful magnetic field on fermentations. Transactions of the Biology Society (Paris), 34: 276 (in French).

    Google Scholar 

  • Drost-Hansen, W., 1956, Temperature anomalies and biological temperature optima in the process of evolution. Naturwissenscaften, 43: 512–515.

    Article  Google Scholar 

  • Durney, C.H., Massoudi, H., Iskander, M.F., 1986, in: Radiofrequency Radiation Dosimetry Handbook, Electrical Eng Depart, University Utah, Salt Lake City, 4th edition.

    Google Scholar 

  • Dvoretsky, A. I., Ayrapetyan, S. N., Shainskaya, A. M., Chebotarev, Y. Y., 1990, in: The membrane ionic transport upon the effect of ionic radiation. Naukovo Dumka, Kiev.

    Google Scholar 

  • Garthwaite, J., 1993, Nitric oxide signaling in the nervous system. Semin. Neurosci. 5: 171–180.

    Article  CAS  Google Scholar 

  • Gharibova, L. S., Avetisian, T.O., Ayrapetian, V.E., Ayrapetyan, S.N., 1996, Effect of SMF on 45Ca influx in excitable and unexcitable cells and proliferative activity of rat spleen cells. Radiobiology and Radioecology, 5: 718–721.

    Google Scholar 

  • Gharibova, L.S., Avetisian, T.H., Ayrapetyan, S.N., 2000, Static Magnetic Field Changes th eActivity of Venom Phospholipase of Snakes. Radiobiology and Radioecology, 40: 441–442.

    Google Scholar 

  • Greengard, P., 1976, Possible role for cyclic nucleotides and phosphorilated membrane proteins in postsynaptic actions of neurotransmitters, Nature, 260: 101–108.

    Article  PubMed  CAS  Google Scholar 

  • Hakobyan, S.N., Ayrapetyan, S. N., 2003, The Effect of SMF, EMF and LF Mechanical Vibration on Water Specific Conductivity. The Bioelectromagnetics Society (BEMS) 25th Annual Meeting, Maui, Hawaii, (P-143-B).

    Google Scholar 

  • Houssinger, D., 1996, Regulation of Cell Function by Hydration, Biochem. J., 313: 697–710.

    Google Scholar 

  • Klassen, V.I., 1982, in: Magnetized Water Systems. “Chemistry” Press, 296 p (in Russian).

    Google Scholar 

  • Livengood, D.R., Kusano, K., 1972, Evidence for an electrogenic Na+ pump in follower cells of the lobster cardiac ganglion. J. Neurophysiology. 35:170–186.

    CAS  Google Scholar 

  • Luben, R.A., 1994, In vitro systems for the study of electromagnetic effects on bone and connective tissue, in: Biological effects of electric and magnetic fields, D.O. Carpenter, S.N. Ayrapetyan, eds., Academic press, New York, 2: 103–119.

    Google Scholar 

  • Minkoff, L., Damadyan, R., 1976, Biological ion exchanger resins, Physiol. Chem. and physics, 8(4):349–362.

    CAS  Google Scholar 

  • Mullins, L.J., 1979, The generation of electric currents in cardiac fibers by the Na/Ca exchange. Am. J. Physiol, 236C: 103–110.

    Google Scholar 

  • Pachomov A. G. et al, 1998, Current State and implications of research on biological effects of millimeter waves, Bioelectromagnetics, 19: 393–413.

    Article  Google Scholar 

  • Pullman, B., Pullman, A., 1963, in: Quantum Biochemistry. Interscience Publisher. New York.

    Google Scholar 

  • Sagian, A. A., Ayrapetyan, S. N., Carpenter, D. O., 1996, Low dose of ouabain stimulates the Na/Ca exchange in Helix neurons. Cell.Mol.Neurobiol., 16: 180–192.

    Google Scholar 

  • Skou, J. C., 1957, The influence of some cations on adenosime trpphosphase from peripheral nerves. Biochem. Biophys. Acta, 23: 394–401.

    Article  PubMed  CAS  Google Scholar 

  • Stepanyan, R.S., Ayrapetyan, G.S., Arakelyan, A.G., Ayrapetyan, S.N., 1999, Effect of Mechanical Oscillations on Electrical Conductivity of Water, Biophysics, 44(2):197–202 (in Russian).

    CAS  Google Scholar 

  • Stepanyan, R. S., Alaverdyan, Zh. R., Oganesyan, H. G., Markosyan ,L. S. and Ayrapetyan, S. N., 2000, The Effect of Magnetic Fields on lon Mutant of Escherichia coli K-12 Growth and Division. Radiational Biology, Radioekology, 40(3):319–322.

    Google Scholar 

  • Ussing, H. H., 1949, Transport of ions across cellular membranes. Physiol Rev. 29: 127–155.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. UNESCO Chair-Life Sciences International, Postgraduate Educational Center, Yerevan, Armenia

    SINERIK N. AYRAPETYAN

Authors
  1. SINERIK N. AYRAPETYAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. UNESCO Chair - Life Sciences International, Postgraduate Educational Center, Yerevan, Armenia

    Sinerik N. Ayrapetyan

  2. Research International, Buffalo Office, Williamsville, Buffalo, NY, U.S.A.

    Marko S. Markov

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer

About this paper

Cite this paper

AYRAPETYAN, S.N. (2006). CELL AQUA MEDIUM AS A PRIMARY TARGET FOR THE EFFECT OF ELECTROMAGNETIC FIELDS. In: Ayrapetyan, S.N., Markov, M.S. (eds) BIOELECTROMAGNETICS Current Concepts. NATO Security Through Science Series. Springer, Dordrecht . https://doi.org/10.1007/1-4020-4278-7_3

Download citation

  • DOI: https://doi.org/10.1007/1-4020-4278-7_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-4276-8

  • Online ISBN: 978-1-4020-4278-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation