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Cell Motility in Cancer Invasion and Metastasis pp 189–220Cite as

Rho GTpases in Cell Motility and Tumorigenesis

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Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 8))

Abstract

Rho proteins are small regulatory molecules that belong to the Ras superfamily of proteins. They act as molecular switches, shuffling between an active, GTP-bound state, and an inactive, GDP-bound state. Upon activation, they interact with a multitude of downstream effectors. In this way Rho proteins regulate a broad range of cellular processes, including cell motility, cell growth, apoptosis, and gene transcription. Therefore, it is not surprising that Rho proteins are also involved in different aspects of tumorigenesis. In particular, as key regulators of cell motility, Rho GTPases are implicated in invasion and metastasis of a tumor. In this review we will focus on the involvement of Rho proteins in cell migration and the different steps of tumorigenesis.

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  1. Department of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Amra Hajdo-Milašinović, Alexander E. Mertens, Irene H. L. Hamelers & John G. Collard

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  1. Amra Hajdo-Milašinović
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  1. Department of Pathology, Pittsburgh VAMC, University of Pittsburgh, PA, USA

    Alan Wells

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Hajdo-Milašinović, A., Mertens, A.E., Hamelers, I.H.L., Collard, J.G. (2006). Rho GTpases in Cell Motility and Tumorigenesis. In: Wells, A. (eds) Cell Motility in Cancer Invasion and Metastasis. Cancer Metastasis - Biology and Treatment, vol 8. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4009-1_9

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