Abstract
Compact bone is a well-organised, multi-level porous structure. Strain-derived fluid flow likely steers the activity of cells within the bone matrix, which in turn orchestrate the concerted activity of bone resorbing and bone forming cells at the surface. We present a model of the strain-driven bone remodelling proces, which could explain the mechanically optimised structure of compact bone.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bergmann, G., Graichen, F. and Rohlmann, A. www.ukbf.fu-berlin.de/biomechanik/Homefrme.htm-<results>-<measurements of hip joint forces>-<walking on a threadmill>-<EBR120B>.
Burger, E.H. and Klein-Nulend, J. (1999) Mechanotransduction in bone-role of the lacuno-canalicular network, FASEB Journal 13, S101–S112
Klein-Nulend, J., Van der Plas, A., Semeins, C.M., Ajubi, N.E., Frangos, J.A., Nijweide, P.J. and Burger, E.H. (1995) Sensitivity of osteocytes to biomechanical stress in vitro, FASEB Journal 9, 441–445
MacIntyre, I., Zaidi, M., Alam, A.S.M.T., Datta, H.K., Moonga, B.S. Lidbury, P.S., Hecker, M. and Vane, J.R. (1991) Osteoclast inhibition: An action of nitric oxide not mediated by cyclic GMP, Proc. Nat. Ac. Sc. 88, 2936–2940
Smit T.H., Huyghe J.M. and Cowin S.C. (2002) A two-level poroelastic model of cortical bone: estimation of the linear isotropic parameters, J. Biomech. 35, 829–836
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer
About this paper
Cite this paper
Smit, T.H., Huyghe, J.M. (2005). Fluid Flow in the Self-Optimised Structure of Compact Bone. In: Gladwell, G.M.L., Huyghe, J., Raats, P.A., Cowin, S.C. (eds) IUTAM Symposium on Physicochemical and Electromechanical Interactions in Porous Media. Solid Mechanics and Its Applications, vol 125. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3865-8_34
Download citation
DOI: https://doi.org/10.1007/1-4020-3865-8_34
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-3864-8
Online ISBN: 978-1-4020-3865-5
eBook Packages: EngineeringEngineering (R0)