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Mechanics of the 21st Century pp 329–342Cite as

Elastic Interactions of Biological Cells

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Abstract

We review recent theoretical work that analyzes experimental measurements of elastic interactions of biological cells with their environment. Recent experiments have shown that adhering cells exert polarized forces on substrates. The interactions of such “force dipoles” in either bulk gels or on surfaces can be used to predict the nature of self-assembly of cell aggregates and may be important in the formation of artificial tissues. Cell adhesion strongly depends on the forces exerted on the adhesion sites by the tension of the cytoskeleton. The size and shape of the adhesion regions is strongly modified as the tension is varied and we present an elastic model that relates this tension to deformations that induce the recruitment of new molecules to the adhesion region.

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Author information

Authors and Affiliations

  1. Dept. Materials and Interfaces, Weizmann Institute of Science, Rehovot, Israel, 76100

    Samuel A. Safran

  2. CRPP, Bordeaux, France, 33600

    A. Nicolas

  3. MPI of Colloids and Interfaces, Potsdam, Germany, 14424

    U. S. Schwarz

Authors
  1. Samuel A. Safran
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  2. A. Nicolas
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  3. U. S. Schwarz
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Editor information

Editors and Affiliations

  1. Polish Academy of Sciences, Warsaw, Poland

    Witold Gutkowski  & Tomasz A. Kowalewski  & 

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© 2005 Springer

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Safran, S.A., Nicolas, A., Schwarz, U.S. (2005). Elastic Interactions of Biological Cells. In: Gutkowski, W., Kowalewski, T.A. (eds) Mechanics of the 21st Century. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3559-4_22

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  • DOI: https://doi.org/10.1007/1-4020-3559-4_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-3456-5

  • Online ISBN: 978-1-4020-3559-3

  • eBook Packages: EngineeringEngineering (R0)

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