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Is Type 1 Diabetes a Disease of the Gut Immune System Triggered by Cow’s Milk Insulin?

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 569))

Abstract

The role of the gut immune system in the development of autoimmune m type 1 diabetes is evaluated in this review with special emphasis in the hypothesis suggesting that dietary cow’s milk insulin could trigger betacell autoimmunity when the mechanisms of oral tolerance are disturbed.

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References

  • Blanas E, Carbone FR, Allison J, Miller JFAP, Heath WR, 1996, Induction of autoimmune diabetes by oral administration of autoantigen. Science 274: 1707–1709.

    Article  PubMed  CAS  Google Scholar 

  • Elliott RB, Reddy SN, Bibby NJ, Kida K, 1998, Dietary prevention of diabetes in the non-obese diabetic mouse. Diabetologia 31: 62–4.

    Google Scholar 

  • Gerstein HC, 1994, Cow’s milk exposure and type I diabetes mellitus. A critical overview of the clinical literature. Diabetes Care 17: 13–9.

    PubMed  CAS  Google Scholar 

  • Hanninen A, Salmi M, Simell O, Jalkanen S, 1996, Mucosa-associated (beta7-integrinhigh) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior. Diabetes 45: 1173–1180.

    PubMed  CAS  Google Scholar 

  • Hanninen A, Jaakkola I, Jalkanen S, 1998, Mucosal addressin is required for the development of diabetes in nonobese diabetic mice. J Immunol 160: 6018–6025.

    PubMed  CAS  Google Scholar 

  • Hanninen A, Salmi M, Simell O, Jalkanen S, 1993,. Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Implications for pathogenesis of IDDM. Diabetes 42: 1556–1562.

    Google Scholar 

  • Kimpimaki T, Erkkola M, Korhonen S, Kupila A, Virtanen SM, Ilonen J, Simell O, Knip M, 2001, Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity. Diabetologia 44: 63–9.

    PubMed  CAS  Google Scholar 

  • Norris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, Rewers M, 2003, Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 290:1713–1720.

    Article  PubMed  CAS  Google Scholar 

  • Paronen J, Klemetti P, Kantele JM, Savilahti E, Perheentupa J, Akerblom HK, Vaarala O, 1997, Glutamate decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut-specific homing receptor alpha4beta7-integrin. Diabetes 46: 583–8.

    PubMed  CAS  Google Scholar 

  • Paronen J, Knip M, Savilahti E, Virtanen SM, Ilonen J, Akerblom HK, Vaarala O, 2000, Effect of cow’s milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group. Diabetes 49: 1657–65.

    PubMed  CAS  Google Scholar 

  • Scott FW, Cloutier HE, Kleemann R, Woerz-Pagenstert U, Rowsell P, Modler HW, Kolb H, 1997, Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells. Diabetes 46: 589–98.

    PubMed  CAS  Google Scholar 

  • Vaarala O, Knip M, Paronen J, Hämäläinen A-M, Muona P, Väätäinen M, Ilonen J, Simell O, Åkerblom HK, 1999, Cow’s milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 48: 1389–1394.

    PubMed  CAS  Google Scholar 

  • Vaarala O, 2002a, Gut immune system and type 1 diabetes. Ann N Y Acad Sci 958: 39–46

    PubMed  CAS  Google Scholar 

  • Vaarala O, Klemetti P, Juhela S, Simell O, Hyöty H, Ilonen J, 2002b,The effect of coincident enterovirus infection and cow’s milk exposure on immunization to insulin in early infancy. Diabetologia 45: 531–534.

    Article  PubMed  CAS  Google Scholar 

  • Verge CF, Howard NJ, Irwig L, Simpson JM, Mackerras D, Silink M, 1994, Environmental factors in childhood IDDM. A population-based, case-control study. Diabetes Care 17: 1381–9.

    PubMed  CAS  Google Scholar 

  • Westerholm-Ormio M, Vaarala O, Pihkanen P, Ilonen J, Savilahti E, 2003, Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes 52: 2287–2295.

    PubMed  CAS  Google Scholar 

  • Virtanen SM, Laara E, Hypponen E, Reijonen H, Rasanen L, Aro A, Knip M, Ilonen J, Akerblom HK, 2000, Cow’s milk consumption, HLA-DQB1 genotypeiabetes. Childhood, and type 1 diabetes: a nested case-control study of siblings of children with d diabetes in Finland study group. Diabetes 49: 912–7.

    PubMed  CAS  Google Scholar 

  • Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E, 2003, Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290:1721–1728.

    Article  PubMed  CAS  Google Scholar 

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Vaarala, O. (2005). Is Type 1 Diabetes a Disease of the Gut Immune System Triggered by Cow’s Milk Insulin?. In: Koletzko, B., Dodds, P., Akerblom, H., Ashwell, M. (eds) Early Nutrition and its Later Consequences: New Opportunities. Advances in Experimental Medicine and Biology, vol 569. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3535-7_22

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  • DOI: https://doi.org/10.1007/1-4020-3535-7_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-3534-0

  • Online ISBN: 978-1-4020-3535-7

  • eBook Packages: MedicineMedicine (R0)

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