Abstract
Rho GTPases have increasingly become recognized as prominent regulators of the microtubule (MT) cytoskeleton. Whereas Rho GTPases regulate the de novo formation of distinct actin arrays (stress fibers, lamellipodia, and filopodia), with MTs, which are present as extensive and dynamic arrays in the absence of Rho GTPase signaling, Rho GTPases principally modify the behavior and dynamics of individual MTs within an existing array. Despite this seemingly modulatory role, Rho GTPases have to profound effects on the MT cytoskeleton. The action of Rho GTPases is primarily exerted at the ends of MTs and causes changes in: (1) dynamics of MT plus ends either through MAPs or sequestering proteins, (2) interactions of MT plus ends with targets in the cortex, in kinetochores or at other sites, a process termed MT capture or (3) the activity of MT minus ends at the centrosome. In many cases, specific GTPases and effectors are known to regulate each of these processes and constitute signaling pathways to regulate MTs. Additionally, MTs can in turn influence the activity of Rho GTPases by interacting with the guanine exchange factors (GEFs) and GTPase activating proteins (GAPs) regulating their function. Together, MTs and Rho GTPases have a dynamic relationship that allows a cell to quickly respond to and integrate a variety of stimuli.
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Eng, C.H., Gundersen, G.G. (2005). Rho Proteins and Microtubules. In: Manser, E. (eds) RHO Family GTPases. Proteins and Cell Regulation, vol 3. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3462-8_12
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