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Metastasis Suppressor Genes: A Brief Review of an Expanding Field

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Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

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Abstract

Metastasis of cancer cells from the primary tumor to form macroscopic lesions at the secondary site is the primary cause of morbidity and mortality in cancer patients. Thus, an understanding of the mechanisms controlling metastasis would allow more effective treatments resulting in better quality of life and higher survival rates. Metastasis suppressor genes prevent metastasis without affecting tumorigenesis and are therefore unique therapeutic targets. In this review, the thirteen defined metastasis suppressor genes are discussed and updated data on the mechanisms of action of these gene products are summarized. Furthermore, work ongoing on a number of potential metastasis suppressor genes for which functional data does not exist is summarized. Finally, important areas of ongoing research that will facilitate translation to the clinic are highlighted.

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Authors and Affiliations

  1. Department of Pathology, Comprehensive Cancer Center, and the National Foundation for Cancer Research — Center for Metastasis Research, University of Alabama, Birmingham, AL, USA

    Monica M. Richert & Danny R. Welch

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  1. Monica M. Richert
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  2. Danny R. Welch
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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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Richert, M.M., Welch, D.R. (2005). Metastasis Suppressor Genes: A Brief Review of an Expanding Field. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_24

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