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Maspin: A Novel Serine Protease Inhibitor

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Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

Abstract

Maspin is a novel serine protease inhibitor differentially expressed in several types of human cancers. Accumulated evidence indicates that maspin plays a tumor suppressive role at the steps of tumor growth, invasion, tumor-induced extracellular matrix remodeling and angiogenesis, and tumor metastasis. Several recent studies also suggest that maspin plays a role in restoring a more differentiated phenotype and enhances tumor cell sensitivity to drug-induced apoptosis. To date, the underlying molecular mechanisms of maspin remain elusive. This review is intended to summarize research progress made in several areas with a focus on whether maspin acts as a serine protease inhibitor. Towards the potential clinical application of maspin in anti-cancer therapies, this review also discusses the current challenges and future research directions.

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Authors and Affiliations

  1. Department of Pathology, Wayne State University School of Medicine, Protease Program of the Karmanos Cancer Insitute, Detroit, MI, USA

    Shijie Sheng

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  1. Shijie Sheng
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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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© 2005 Springer

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Sheng, S. (2005). Maspin: A Novel Serine Protease Inhibitor. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_23

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