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Dietary Restriction of Specific Amino Acids Modulates Tumor and Host Interactions

  • Chapter
Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

Abstract

Nutrients modulate host metabolism that lead to changes in biological and molecular responses. Thus, it is not surprising that tumor cells also are affected by changes in host nutrition. Because tumors have altered or mutated genes, they often respond differently to metabolic changes than the host. Many tumors have altered or specific requirements for amino acids, and restriction often can curtail growth/cell death, invasion, and/or metastasis of tumor cells without detrimental effects on the host. This chapter reviews the effects that various specific amino acid restriction has on tumor cells themselves and the effects on interaction between the host stromal components. The cell signalling pathways that modulate attachment, motility and invasion are discussed. Also included are in vivo studies encompasing the interactions between the host immune response and B16BL6 melanoma during dietary restriction of tyrosine and phenylalanine. Lastly, the potential for amino acid restriction as one element of adjuvant therapy to control cancer progression is discussed.

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  1. Cancer Prevention & Research Center, Department of Pharmaceutical Sciences, The Pharmacology & Toxicology Graduate Program, and the College of Pharmacy, Washington State University, Box 646510, Pullman, WA, 99164-6510, USA

    G. G. Meadows & Y.-M. Fu

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  1. G. G. Meadows
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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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Meadows, G.G., Fu, YM. (2005). Dietary Restriction of Specific Amino Acids Modulates Tumor and Host Interactions. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_16

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