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Integration/Interaction of Oncologic Growth pp 259–270Cite as

Anti-Angiogenic and Pro-Apoptotic Effects of Dietary Restriction in Experimental Brain Cancer: Role of Glucose and Ketone Bodies

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Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

Abstract

Angiogenesis involves neovascularization or the formation of new capillaries from existing blood vessels and is associated with the processes of tissue inflammation, wound healing, and tumorigenesis. Recent studies from this laboratory show that moderate restriction of dietary energy intake (dietary restriction, DR) has powerful anti-angiogenic and pro-apoptotic effects against the CT-2A experimental mouse astrocytoma. DR reduces blood glucose levels while elevating ketone bodies. As most brain tumour cells are dependent on glycolysis for energy due to mitochondrial defects, they are unable to switch from glucose to ketone bodies for energy. An energy source shift from glucose to ketone bodies will enhance the bioenergetic potential of normal brain cells while reducing tumour cell growth and tissue inflammation. It is suggested that cancer therapeutics that reduce tumour growth, while also reducing food intake and body weight, may operate in large part through the anti-angiogenic and pro-apoptotic effects of DR.

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  1. Biology Department, Boston College, Chestnut Hill, MA, 02467, USA

    T.N. Seyfried & P. Mukherjee

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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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Seyfried, T., Mukherjee, P. (2005). Anti-Angiogenic and Pro-Apoptotic Effects of Dietary Restriction in Experimental Brain Cancer: Role of Glucose and Ketone Bodies. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_15

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