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References

  1. Robson, M.C.; Barnett, R.A.; Leitch, I.O. and Hayward, P.G. (1992) Prevention and treatment of postburn scars and contracture. World J. Surg. 16: 87–96.

    Article  PubMed  CAS  Google Scholar 

  2. McHugh, A.A.; Fowlkes, B.J.; Maevsky, E.I.; Smith, D.J. Jr.; Rodriguez, J.L. and Garner, W.L. (1997) Biomechanical alterations in normal skin and hypertrophic scar after thermal injury. J. Burn Care Rehabil. 18: 104–108.

    PubMed  CAS  Google Scholar 

  3. Mast, B.A and Newton, E.D. (1996) Aggressive use of free flaps in children for burn scar contractures and other soft-tissue deficits. Ann. Plast. Surg. 36: 569–575.

    PubMed  CAS  Google Scholar 

  4. Isenberg, J.S. and Price, G. (1996) Longitudinal trapezius fasciocutaneous flap for the treatment of mentosternal burn scar contractures. Burns 22: 76–79.

    Article  PubMed  CAS  Google Scholar 

  5. Asmursen, P.D. (1986) Einfurung and Grundlage: Rohstoffe, Die Hant, Klebetchnologie, Hamburg Ag. Compendium Medical, Berlin: Hamburg, Biersdorf, vol. 1.

    Google Scholar 

  6. Mast, B.A. (1992) The skin. In: Cohen, I.K.; Diegelmann, R.F. and Lindbald, W.J. (Eds.) Wound healing: biochemical and clinical aspects, W.B. Saunders, Philadelphia, USA; pp. 344–355.

    Google Scholar 

  7. Clark, R.A.F. and Henson, P.M. (1988) The molecular and cellular biology of wound repair. Plenum Press, New York, USA.

    Google Scholar 

  8. Jennings, R.W. and Hung, T.K. (1992) In: Adzick, N.S. and Longacker, M.T. (Eds.) Fetal wound healing. Elsevier, New York, USA; pp. 25.

    Google Scholar 

  9. Calvin, M. (1998) Cutaneous wound repair Wounds. A Compendium of Clinical Research and Practice 12, pp. 32.

    Google Scholar 

  10. Gallico, G.G. 3rd.; O’Connor, N.E.; Compton, C.C.; Kehinde, O. and Green, H. (1984) Permanent coverage of large burn wounds with autologous cultured human epithelium. N. Engl. J. Med. 311(7): 448–51.

    Article  PubMed  Google Scholar 

  11. Limova, M. and Mauro, T. (1995) Treatment of leg ulcers with cultured epithelial autografts: clinical study and case reports. Ostomy Wound Manage 41(8): 48–50, 52, 54–60.

    PubMed  CAS  Google Scholar 

  12. Pruitt, B.A. Jr. and Levine, S. (1984) Characteristics and uses of biologic dressings and skin substitutes. Arch. Surg. 199: 312–322.

    Google Scholar 

  13. Hansbrough, J.F. (1992) Wound coverage with biologic dressings and cultured skin substitutes. Landes, Austin, USA.

    Google Scholar 

  14. Odessey, R. (1992) Addendum: Multicenter experience with cultured epithelial autografts for treatment of burns. J. Burn Care Rehabil. 13: 174–180.

    PubMed  CAS  Google Scholar 

  15. Pittelkow, M.R. and Scott, R.E. (1986) New techniques for the in vitro culture of human skin keratinocytes and perspectives on their use for grafting of patients with extensive burns. Mayo Clin. Proc. 61: 771–777.

    PubMed  CAS  Google Scholar 

  16. Boyce, S.T.; Greenhalgh, D.G.; Kagan, R.J.; Housinger, T.; Sorrell, J.M.; Childress, C.P.; Rieman, M. and Warden, G.D. (1993) Skin anatomy and antigen expression after burn wound closure with composite grafts of cultured skin cells and biopolymers. Plast. Reconstr. Surg. 91: 632–641.

    PubMed  CAS  Google Scholar 

  17. Desai, M.H.; Mlakar, J.M.; McCauley, R.L.; Abdullah, K.M.; Rutan, R.L.; Waymack, J.P.; Robson, M.C. and Herndon, D.N. (1991) Lack of long term durability of cultured keratinocyte burn wound coverage: a case report. J. Burn Care Rehabil. 12: 540–545.

    Article  PubMed  CAS  Google Scholar 

  18. Williamson, J.S.; Snelling, C.F.; Clugston, P.; Macdonald, I.B. and Germann, E. (1995) Cultured epithelial autograft: Five years of clinical experience with twenty-eight patients. J. Trauma 39: 309–319.

    PubMed  CAS  Google Scholar 

  19. Rue, L.W.; Cioffi, W.G.; McManus, W.F. and Pruitt, B.A. Jr. (1993) Wound closure and outcome in extensively burned patients treated with cultured autologous keratinocytes. J. Trauma 34: 662–667.

    PubMed  Google Scholar 

  20. Boyce, S.T. and Warden G.D. (2002) Principles and practices for treatment of cutaneous wounds with cultured skin substitutes. Am. J. Surg. 183: 445–456.

    Article  PubMed  Google Scholar 

  21. Coulomb, B. and Dubertret, L. (2002) Skin cell culture and wound healing. Wound Rep. Regen. 10:109.

    Article  Google Scholar 

  22. Rennekampff, H.O.; Kiessig, V. and Hansbrough, J.F. (1996) Current concepts in the development of cultured skin replacements. J. Surg. Res. 62(2): 288–295.

    Article  PubMed  CAS  Google Scholar 

  23. Rennekampff, H.O.; Kiessig, V.; Griffey, S.; Greenleaf, G. and Hansbrough, J.F. (1997) Acellular human dermis promotes cultured keratinocyte engraftment. J. Burn Care Rehabil. 18(6): 535–544.

    PubMed  CAS  Google Scholar 

  24. Oksala, O.; Salo, T.; Tammi, R.; Hakkinen, L.; Jalkanen, M.; Inki, P. and Larjava, H. (1995) Expression of proteoglycans and hyaluronan during wound healing. J. Histochem. Cytochem. 43(2): 125–135.

    PubMed  CAS  Google Scholar 

  25. Zacchi, V.; Soranzo, C.; Cortivo, R.; Radice, M.; Brun, P. and Abatangelo, G. (1998) In vitro engineering of human skin-like tissue. J. Biomed. Mater. Res. 40(2): 187–194.

    Article  PubMed  CAS  Google Scholar 

  26. Fusenig, N.E.; Limat, A.; Stark, H.J. and Breitkreutz, D. (1994) Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis. J. Dermatol. Sci. Jul. 7 suppl. S142–151.

    Google Scholar 

  27. Lamme, E.N.; de Vries, H.J.; van Veen, H.; Gabbiani, G.; Westerhof, W. and Middelkoop, E. (1996) Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs. J. Histochem. Cytochem. 44(11): 1311–1322.

    PubMed  CAS  Google Scholar 

  28. Falanga, V. (1998) Apligraf treatment of venous ulcers and other chronic wounds. J. Dermatol. 25(12): 812–817.

    PubMed  CAS  Google Scholar 

  29. Falanga, V.; Margolis, D.; Alvarez, O.; Auletta, M.; Maggiacomo, F.; Altman, M.; Jensen, J.; Sabolinski, M. and Hardin-Young, J. (1998) Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group. Arch. Dermatol. 134: 293–300.

    Article  PubMed  CAS  Google Scholar 

  30. Galassi, G.; Brun, P.; Radice, M.; Cortivo, R.; Zanon, G.F.; Genovese, P. and Abatangelo, G. (2000) In vitro reconstructed dermis implanted in human wounds: degradation studies of the HA-based supporting scaffold. Biomaterials 21(21): 2183–91.

    Article  PubMed  CAS  Google Scholar 

  31. Cuono, C.B.; Langdon, R.; Birchall, N.; Barttelbort, S. and McGuire, J. (1987) Composite autologous-allogenic skin replacement: development and clinical application. Plast. Reconstr. Surgery 80: 626–35.

    Article  CAS  Google Scholar 

  32. Compton, C.C.; Gill, J.F.; Bradford, D.A.; Regauer, S.; Gallico, G.G. and O’Connor, N.E. (1989) Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. Lab. Invest. 60: 600–612.

    PubMed  CAS  Google Scholar 

  33. Neveux, Y.; Rives, J.M.; Lebreton, C.; Gentilhomme, E.; Saint-Blancar, P. and Carsin, M. (1995) Clinical interest of cutaneous models reproduced in vitro for severeburn treatment: histopathologic and ultrastructural study. Cell Biol. Toxicol. 11: 173–178.

    Article  PubMed  CAS  Google Scholar 

  34. Sher, S.E.; Hull, B.E.; Rosen, S.; Church, D.; Friedman, L. and Bell, E. (1983) Acceptance of allogeneic fibroblasts in skin equivalent transplants. Transplant. 36: 5052–5057.

    Google Scholar 

  35. Sorrell, J.M.; Carrino, D.A.; Baber, M.A.; Asselinean, D. and Caplan, A.I. (1999) A monoclonal antibody recognizes a glycosaminoglycan epitope in both dermatan sulfate and chondroitin sulfate proteoglycans of human skin. Histochem. J. 31: 549–558.

    Article  PubMed  CAS  Google Scholar 

  36. Prockop, D. (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71–74.

    Article  PubMed  CAS  Google Scholar 

  37. Bucala, R.; Spiegel, L.; Chesney, J.; Hogan, M. and Cerami, A. (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol. Med. 1: 71–81.

    PubMed  CAS  Google Scholar 

  38. Leigh, I.M.; Purkis, P.E.; Navsaria, H.A.; Phillips, T.J. (1987) Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br. J. Dermatol. 117: 591–597.

    PubMed  CAS  Google Scholar 

  39. De Luca, M.; D’Anna, F.; Bondanza, S.; Franzi, A.T. and Cancedda, R. (1992) Treatment of leg ulcers with cryopreserved allogeneic cultured epithelium — a multicenter study. Arch. Dermatol. 28: 633–638.

    Article  Google Scholar 

  40. Mol, M.A.; Nanninga, P.B.; van Eendenburg, J.P.; Westerhof, W.; Mekkes, J.R. and van Ginkel, C.J. (1991) Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts. J. Am. Acad. Dermatol. 24: 77–82.

    Article  PubMed  CAS  Google Scholar 

  41. Teepe, R.G.; Koebrugge, E.J.; Ponec, M. and Vermeer, B.J. (1990) Fresh versus cryopreserved cultured allografts for the treatment of chronic skin ulcers. Br. J. Dermatol. 122: 81–89.

    PubMed  CAS  Google Scholar 

  42. Teepe, R.G.; Roseeuw, D.I.; Hermans, J.; Koebrugge, E.J.; Altena, T.; de Coninck, A.; Ponec, M. and Vermeer, B.J. (1993) Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers. J. Am. Acad. Dermatol. 29: 982–988.

    Article  PubMed  CAS  Google Scholar 

  43. Phillips, T.J.; Kehinde, O.; Green, H. and Gilchrest, B.A. (1989) Treatment of skin ulcers with cultured epidermal allografts. J. Am. Acad. Dermatol. 21: 191–199.

    Article  PubMed  CAS  Google Scholar 

  44. Gilchrest, B.A. (1983) In vitro assessment of keratinocyte aging. J. Invest. Dermatol. 81: 184s–189s.

    Article  PubMed  CAS  Google Scholar 

  45. Trent, J.F. and Kirsner, R.S. (1998) Tissue engineered skin: Apligraf, a bi-layered living skin equivalent. Int. J. Clin. Pract. 52: 408–413.

    PubMed  CAS  Google Scholar 

  46. Parenteau, N.L. (1998) Skin equivalents, In: Leigh, I.M. and Watt, F.M. (Eds.) Keratinocytes methods. Cambridge University Press, London; pp. 44–55.

    Google Scholar 

  47. Eaglstein, W.H. and Falanga, V. (1998) Tissue engineering and the development of Apligraft a human skin equivalent. Adv. Wound Care 11: 1–8.

    PubMed  CAS  Google Scholar 

  48. Eaglstein, W.H.; Iriondo, M. and Laszlo, K. (1995) A composite skin substitute (graftskin) for surgical wounds. A clinical experience. Dermatol. Surg. 10: 839–843.

    Article  Google Scholar 

  49. Yannas, I.V.; Burke, J.F.; Gordon, P.L.; Huang, C. and Rubenstein, R.H. (1980) Design of an artificial skin. II. Control of chemical composition. J. Biomed. Mater. Res. 14: 107–132.

    Article  PubMed  CAS  Google Scholar 

  50. Burke, J.F. (1987) Observations on the development and clinical use of artificial skin-an attempt to employ regeneration rather than scar formation in wound healing. Jpn. J. Surg. 17: 431–438.

    PubMed  CAS  Google Scholar 

  51. Bruke, J.F. (1984) The effects of the configuration of an artificial extracellular matrix on the development of a functional dermis. In: Trelstad, R. (Ed.) The role of extracellular matrix in development, Liss, New York; pp. 351–355.

    Google Scholar 

  52. Purdue, G.F.; Hunt, J.L.; Still, J.M. Jr.; Law, E.J.; Herndon, D.N.; Goldfarb, I.W.; Schiller, W.R.; Hansbrough, J.F.; Hickerson, W.L.; Himel, H.N.; Kealey, G.P.; Twomey, J.; Missavage, A.E.; Solem, L.D.; Davis, M.; Totoritis, M. and Gentzkow, G.D. (1997) A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. J. Burn Care Rehabil. 18: 52–57.

    PubMed  CAS  Google Scholar 

  53. Hansbrough, J.F.; Mozingo, D.W.; Kealey, G.P.; Davis, M.; Gidner, A. and Gentzkow, G.D. (1997) Clinical trials of a biosynthetic temporary skin replacement, Dermagraft Transitional Covering, compared with cryopreservedhuman cadaver skin for temporary coverage of excised burn wounds. J. Burn Care Rehabil. 18: 43–51.

    PubMed  CAS  Google Scholar 

  54. Purdue, G.F. (1996) Dermagraft-TC pivotal safety and efficacy study. J. Burn Care Rehabil. 18: 513–514.

    Google Scholar 

  55. Haeri, A.; Clay, J. and Finely, J.M. (1999) Compend Contin Educ The use of an acellular dermal skin graft to gain keratinized tissue. Dent. 1999 20(3): 233–234, 239–242 (quiz 244).

    CAS  Google Scholar 

  56. Schwartz, S. (1997) In: A new composite cultured skin product for treatment of burns and other deep dermal injuries. Presented at the Bioengineering of Skin Substitutes Conference. Boston, Mass. (USA); pp. 19.

    Google Scholar 

  57. Beumer, G.J.; van Blitterswijk, C.A.; Bakker, D. and Ponec, M. (1993) A new biodegradable matrix as part of a cell seeded skin substitute for the treatment of deep skin defects: a physico-chemical characterisation. Clin. Mater. 14(1): 21–27.

    Article  PubMed  CAS  Google Scholar 

  58. Noordenbos, J.; Dore, C. and Hansbrough, J.F. (1999) Safety and efficacy of TransCyte for the treatment of partial-thickness burns. J. Burn Care Rehabil. 20(4): 275–281.

    PubMed  CAS  Google Scholar 

  59. Chen, W.Y.J. and Abatangelo, G. (1999) The functions of Hyaluronan in wound repair. Wound Rep. Reg. 7: 79–89.

    Article  CAS  Google Scholar 

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Zavan, B., Cortivo, R., Brun, P., Tonello, C., Abatangelo, G. (2005). Bioartificial Skin. In: Nedović, V., Willaert, R. (eds) Applications of Cell Immobilisation Biotechnology. Focus on Biotechnology, vol 8B. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3363-X_3

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