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Arf6

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ARF Family GTPases

Part of the book series: Proteins and Cell Regulation ((PROR,volume 1))

Abstract

Arf6 is the sole representative of the class III Arfs and is the most divergent (both structurally and functionally) of the Arfs. Its localization to the plasma membrane and endosomal system also distinguishes it from the other five Arfs. Both the localization of Arf6 and its functional roles in endocytosis, secretion, and desensitization of G-protein coupled receptors exhibit cell type-specificity, making comparative studies difficult and often confusing. Finally, models for Arf6 in actin organization and phospholipid signaling are discussed.

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  1. Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, USA

    James E. Casanova

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Casanova, J.E. (2004). Arf6. In: ARF Family GTPases. Proteins and Cell Regulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2593-9_14

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  • DOI: https://doi.org/10.1007/1-4020-2593-9_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1719-3

  • Online ISBN: 978-1-4020-2593-8

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