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Phospholipase D, Arfaptins and Arfophilin

  • Chapter
ARF Family GTPases

Part of the book series: Proteins and Cell Regulation ((PROR,volume 1))

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Abstract

The effects of Arfs on three potential effectors (phospholipase D, Arfaptins and Arfophilin) are described. Arfs activate mammalian PLD1 in vitro, but their roles in the regulation of PLD in vivo are not well defined. Direct binding of Arfs to PLD1 has not been demonstrated in vitro and activation may involve PI(4,5)P2, which binds to the enzyme. Evidence for a role of Arf6 in the regulation of PLD in vivo is accumulating and may partly involve a PIP kinase that is activated by this Arf. The role of Arf-stimulated PLD in Golgi traffic remains controversial and evidence for and against this is presented. The properties of the Arf-binding proteins Arfaptins 1 and 2 are described, and interactions of POR1, a truncated form of Arfaptin 2, with Arfs and Rac1 are discussed. A hypothesis for Arfaptin 2 as a communicator between these two small GTPases in vivo is presented. A possible role of Arfaptin 2 in Huntington’s disease is discussed. Finally, the properties of Arfophilin, which selectively binds ARFs 4, 5 and 6 are described.

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  1. Department of Molecular Physiology, Biophysics and Pharmacology, Howard Hughes Medical Institute, Vanderbilt University, Nashville, USA

    John H. Exton

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© 2004 Springer Science + Business Media, Inc.

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Exton, J.H. (2004). Phospholipase D, Arfaptins and Arfophilin. In: ARF Family GTPases. Proteins and Cell Regulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2593-9_11

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  • DOI: https://doi.org/10.1007/1-4020-2593-9_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1719-3

  • Online ISBN: 978-1-4020-2593-8

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