Summary
Increasing life expectancy has raised health problems with respect to „normal”aging, and particularly to age related disorders. This holds true for several brain diseases in middle, and more frequently, in old age such as stroke (brain ischemia), Parkinson’s disease and dementia of either vascular origin or sporadic Alzheimer type.
Cellular and molecular mechanisms in mammalian brain during adult life and their variations in old age will be discussed in this chapter to get insight into processes which may be risk factors (burden) for age-associated brain diseases or into processes which may be able to prevent such brain disorders. In this respect, focus is laid on oxidative energy and related metabolism what had been demonstrated to meet the functional and structural requirements of the brain.
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References
Blanchard RJ, McKittrick CR, Blanchard DC (2001) Animal models of social stress: effects on behavior and brain neurochemical systems. Physiol Behav 73: 261–271
Conejo R, Lorenzo M (2001) Insulin signalling leading to proliferation, survival and membrane ruffling in C2 C12 myoblasts. J Cell Physiol 187: 96–108
Degrell I, Krier C, Hoyer S (1983) Carbohydrate and energy metabolism of the aging rat brain in severe arterial hypoxemia. In: Cervos-Navarro J, Sarkander HI (eds) Neuropathology and Neuropharmacology, Aging Series Vol 21, Raven, New York, 289–300
Dutschke K, Nitsch RM, Hoyer S (1994) Short-term mental activation accelerates the age-related decline in brain tissue levels of high-energy phosphates. Arch Gerontol Geriatr 19: 43–51
Farkas E, Luiten PGM (2001) Cerebral microvascular pathology in aging and Alzheimer’s disease. Prog Neurobiol 64: 575–611
Heiland S, Sartor K, Martin E et al (2002) In vivo monitoring of age-related changes in rat brain using quantitative diffusion magnetic resonance imaging and magnetic resonance relaxometry. Neurosci Lett 334: 157–160
Henneberg N, Hoyer S (1994) Short-term or long-term intracerebroventricular (icv) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat. Neurosci Lett 174: 153–156
Holness MJ, Langdown ML, Sugden MC (2000) Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of type 2 diabetes mellitus. Biochem J 349: 657–665
Hong MF, Lee VMY (1997) Insulin and insulin-like factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 272: 19547–19553
Hoyer S (1985) The effect of age on glucose and energy metabolism in brain cortex of rats. Arch Gerontol Geriatr 4: 193–203
Hoyer S (1995) Brain metabolism during aging. In: Macieira-Coelho A (ed) Molecular basis of aging. CRC Press, Boca Raton, pp 493–510
Jiang CH, Tsien JZ, Schultz PG et al (2001) The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sei USA 98: 1930–1934
Lesort M, Jope RS, Johnson GVW (1999) Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase. F-3ß and Fyn tyrosine kinase. J Neurochem 72: 576–584
Lupien S, Lecours AR, Lussier I et al (1994) Basal Cortisol levels and cognitive deficits in human aging. J Neurosci 14: 2893–2903
O’Sullivan M, Jones DK, Summers PE et al (2001) Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline. Neurology 57: 632–638
Park CR (2001) Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25: 311–323
Plaschke K, Yun SW, Martin E et al (1999) Interrelation between cerebral energy metabolism and behaviour in a rat model of permanent brain vessel occlusion. Brain Res 830: 320–329
Plaschke K, Martin E, Bardenheuer HJ et al (2000) Transfemoral digital subtraction angiography for assessment of vertebral artery occlusion in rats. Stroke 31: 1789–1790
Plata-Salaman CR (1991) Insulin in the cerebrospinal fluid. Neurosci Biobehav Rev 15: 243–258
Popa-Wagner A, Schroder E, Schmoll H et al (2001) The role of growth-promoting and growth-inhibiting factors in neurorepair after stroke. Effect of age. In: Current Concepts in Experimental Gerontology. C Bertoni-Freddari/H Niedermüller (ed) pp: 177–201
Sapolsky RM (1994) Glucocorticoids, stress and exacerbation of excitotoxic neuron death. Sem Neurosci 6:323–331
Siesjö BK (1978) Brain energy metabolism. Wiley, Chichester, pp 1–28, pp 151–209
Smith CD, Carney JM, Starke-Reed PE et al (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer’s disease. Proc Natl Acad Sei USA 88: 10540–10543
Suzuki T, Oishi M, Marshak DR et al (1994) Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J 13: 1114–1122
Sykova E, Mazel T, Hasenohrl RU, Harvey AR, Simonova Z, Mulders WH, Huston JP (2002) Learning deficits in aged rats related to decrease in extracellular volume and loss of diffusion anisotropy in hippocampus. Hippocampus 12(2):269–79
Uylings HBM, deBrabander JM (2002) Neuronal changes in normal human aging and Alzheimer’s disease. Brain Cognition 49: 268–276
Vlassara H, Bucala R, Striker L (1994) Biology of disease. Pathogenetic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 70: 138–151
White MF, Kahn CR (1994) The insulin signalling system. J Biol Chem 269: 1–4
Xie L, Heimerhorst E, Taddel K et al (2002) Alzheimer’s ß-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 22: RC 221(1–5)
Yun SW, Gärtner U, Arendt T, Hoyer S (2000) Increase in vulnerability of middle-aged rat brain to lead by cerebral energy depletion. Brain Res Bull 52: 371–378
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Hoyer, S., Plaschke, K. (2004). The Aging Brain — the Burden of Life (?). In: Herdegen, T., Delgado-García, J. (eds) Brain Damage and Repair. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2541-6_1
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DOI: https://doi.org/10.1007/1-4020-2541-6_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-6538-4
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