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References
Adams GR, Hather BM, Dudley GA (1994) Effect of short-term unweighting on human skeletal muscle strength and size. Aviat Space Environ Med 65: 1116-1121
Akima H, Katayama K, Sato K et al. (2005) Intensive cycle training with artificial gravity maintains muscle size during bed rest. Aviat Space Environ Med 76: 923-929
Alkner BA, Tesch PA (2004a) Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest. Acta Physiol Scand 181: 345-357
Alkner BA, Tesch PA (2004b) Knee extensor and plantar flexor muscle size and function following 90 days of bed rest with or without resistance exercise. Eur J Appl Physiol 93: 294-305
Andersen JL, Mohr T, Biering-Sorensen Fet al. (1996) Myosin heavy chain isoform transformation in single fibers from m. vastus lateralis in spinal cord injured individuals: effects of long-term functional electrical stimulation (FES). Pflugers Arch 431: 513-518
Antonutto G, Bodem F, Zamparo Pet al. (1998) Maximal power and EMG of lower limbs after 21 days spaceflight in one astronaut. J Gravit Physiol 5: P63-66
Antonutto G, Capelli C, Di Prampero PE (1991) Pedaling in space as a countermeasure to microgravity deconditioning. Microgravity Quarterly 1: 93-101
Antonutto G, Capelli C, Girardis Met al. (1999) Effects of microgravity on maximal power of lower limbs during very short efforts in humans. J Appl Physiol 86: 85-92
Antonutto G, Di Prampero PE (2003) Cardiovascular deconditioning in microgravity: some possible countermeasures. Eur J Appl Physiol 90: 283-291
Antonutto G, Linnarsson D, Di Prampero PE (1993) On-Earth evaluation of neurovestibular tolerance to centrifuge simulated artificial gravity in humans. Physiologist 36: S85-S87
Baerwalde S, Zange J, Muller Ket al. (1999) High-energy-phosphates measured by 31P-MRS during LBNP in exercising human leg muscle. J Gravit Physiol 6: P37-38
Baldwin KM, Haddad F (2001) Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle. J Appl Physiol 90: 345-357
Baldwin KM, Haddad F (2002) Skeletal muscle plasticity: cellular and molecular responses to altered physical activity paradigms. Am J Phys Med Rehabil 81: S40-51
Baldwin KM, Herrick RE, McCue SA (1993) Substrate oxidation capacity in rodent skeletal muscle: effects of exposure to zero gravity. J Appl Physiol 75: 2466-2470
Bamman MM, Clarke MS, Feeback DL et al. (1998) Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution. J Appl Physiol 84: 157-163
Bamman MM, Hunter GR, Stevens BRet al. (1997) Resistance exercise prevents plantar flexor deconditioning during bed rest. Med Sci Sports Exerc 29: 1462-1468
Berg HE, Dudley GA, Haggmark Tet al. (1991) Effects of lower limb unloading on skeletal muscle mass and function in humans. J Appl Physiol 70: 1882-1885
Berg HE, Dudley GA, Hather Bet al. (1993) Work capacity and metabolic and morphologic characteristics of the human quadriceps muscle in response to unloading. Clin Physiol 13: 337-347
Berg HE, Larsson L, Tesch PA (1997) Lower limb skeletal muscle function after 6 wk of bed rest. J Appl Physiol 82: 182-188
Berg HE, Tesch PA (1996) Changes in muscle function in response to 10 days of lower limb unloading in humans. Acta Physiol Scand 157: 63-70
Berg HE, Tesch PA (1998) Force and power characteristics of a resistive exercise device for use in space. Acta Astronautica 42: 219-230
Bigard AX, Merino D, Lienhard Fet al. (1997) Muscle damage induced by running training during recovery from hindlimb suspension: the effect of dantrolene sodium. Eur J Appl Physiol 76: 421-427
Biolo G, Ciocchi B, Lebenstedt M et al. (2004) Short-term bed rest impairs amino acid-induced protein anabolism in humans. J Physiol 558: 381-388
Bleakney R, Maffulli N (2002) Ultrasound changes to intramuscular architecture of the quadriceps following intramedullary nailing. J Sports Med Phys Fitness 42: 120-125
Blottner D, Salanova M, Puttmann B et al. (2006) Human skeletal muscle structure and function preserved by vibration muscle exercise following 55 days of bed rest. Eur J Appl Physiol 97: 261-271
Bottinelli R (2001) Functional heterogeneity of mammalian single muscle fibers: do myosin isoforms tell the whole story? Pflugers Arch 443: 6-17
Bottinelli R, Reggiani C (2000) Human skeletal muscle fibers: molecular and functional diversity. Prog Biophys Mol Biol 73: 195-262
Burton B, Russel R (1994) Artificial gravity in space flight. J Gravit Physiol 1: 15-18
Caiozzo VJ, Baker MJ, Herrick RE (1994) Effect of spaceflight on skeletal muscle: Mechanical properties and myosin isoform content of a slow muscle. J Appl Physiol 76: 1764-1773
Caiozzo VJ, Haddad F, Baker MJ et al. (1996) Microgravity-induced transformations of myosin isoforms and contractile properties of skeletal muscle. J Appl Physiol 81: 123-132
Chase GA, Grave C, Rowell LB (1966) Independence of changes in functional and performance capacities attending prolonged bed rest. Aerosp Med 37: 1232-1238
Chi MM, Choksi R, Nemeth P et al. (1992) Effects of microgravity and tail suspension on enzymes of individual soleus and tibialis anterior fibers. J Appl Physiol 73: 66S-73S
Convertino VA (1991) Neuromuscular aspects in development of exercise counter-measures. Physiologist 34: S125-128
Convertino VA (2002) Planning strategies for development of effective exercise and nutrition countermeasures for long-duration space flight. Nutrition 18: 880-888
Convertino VA, Doerr DF, Stein SL (1989) Changes in size and compliance of the calf after 30 days of simulated microgravity. J Appl Physiol 66: 1509-1512
D'Amelio F, Daunton NG (1992) Effects of spaceflight in the adductor longus muscle of rats flown in the Soviet Biosatellite COSMOS 2044. A study employing neural cell adhesion molecule (N-CAM) immunocytochemistry and conventional morphological techniques (light and electron microscopy). J Neuropathol Exp Neurol 51: 415-431
D'Antona G, Pellegrino MA, Adami R et al. (2003) The effect of ageing and immobilization on structure and function of human skeletal muscle fibers. J Physiol 552: 499-511
De-Doncker L, Kasri M, Picquet Fet al. (2005) Physiologically adaptive changes of the L5 afferent neurogram and of the rat soleus EMG activity during 14 days of hindlimb unloading and recovery. J Exp Biol 208: 4585-4592
Desplanches D, Mayet MH, Ilyina-Kakueva EIet al. (1991) Structural and metabolic properties of rat muscle exposed to weightlessness aboard Cosmos 1887. Eur J Appl Physiol Occup Physiol 63: 288-292
Di Prampero PE (2000) Cycling on Earth, in space, on the Moon. Eur J Appl Physiol 82: 345-360
Di Prampero PE, Narici MV (2003) Muscles in microgravity: from fibers to human motion. J Biomech 36: 403-412
Duchateau J (1995) Bed rest induces neural and contractile adaptations in triceps surae. Med Sci Sports Exerc 27: 1581-1589
Duchateau J, Hainaut K (1987) Electrical and mechanical changes in immobilized human muscle. J Appl Physiol 62: 2168-2173
Dudley GA, Gollnick PD, Convertino VAet al. (1989) Changes of muscle function and size with bedrest. Physiologist 32: S65-66
Dudley GA, Hather BM, Buchanan P (1992) Skeletal muscle responses to unloading with special reference to man. J Fla Med Assoc 79: 525-529
Duvoisin MR, Convertino VA, Buchanan Pet al. (1989) Characteristics and preliminary observations of the influence of electromyostimulation on the size and function of human skeletal muscle during 30 days of simulated microgravity. Aviat Space Environ Med 60: 671-678
Edgerton VR, McCall GE, Hodgson JA et al. (2001) Sensorimotor adaptations to microgravity in humans. J Exp Biol 204: 3217-3224
Edgerton VR, Roy RR (1994) Neuromuscular adaptation to actual and simulated weightlessness. Adv Space Biol Med 4: 33-67
Edgerton VR, Zhou MY, Ohira Y et al. (1995) Human fiber size and enzymatic properties after 5 and 11 days of spaceflight. J Appl Physiol 78: 1733-1739
Ferrando AA, Lane HW, Stuart CAet al. (1996) Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol 270: E627-633
Ferrando AA, Paddon-Jones D, Wolfe RR (2002) Alterations in protein metabolism during space flight and inactivity. Nutrition 18: 837-841
Ferrando AA, Tipton KD, Bamman MM, et al. (1997) Resistance exercise maintains skeletal muscle protein synthesis during bed rest. J Appl Physiol 82: 807-810
Ferretti G, Antonutto G, Denis C et al. (1997) The interplay of central and peripheral factors in limiting maximal O2 consumption in man after prolonged bed rest. J Physiol 501: 677-686
Ferretti G, Berg HE, Minetti AE et al. (2001) Maximal instantaneous muscular power after prolonged bed rest in humans. J Appl Physiol 90: 431-435
Fitts RH, Riley DR, Widrick JJ (2000) Physiology of a microgravity environment invited review: microgravity and skeletal muscle. J Appl Physiol 89: 823-839
Fitts RH, Riley DR, Widrick JJ (2001) Functional and structural adaptations of skeletal muscle to microgravity. J Exp Biol 204: 3201-3208
Fluckey JD, Dupont-Versteegden EE, Montague DC et al. (2002) A rat resistance exercise regimen attenuates losses of musculoskeletal mass during hindlimb suspension. Acta Physiol Scand 176: 293-300
Gamrin L, Berg HE, Essen P et al. (1998) The effect of unloading on protein synthesis in human skeletal muscle. Acta Physiol Scand 163: 369-377
Greenleaf JE, Bernauer EM, Ertl ACet al. (1989) Work capacity during 30 days of bed rest with isotonic and isokinetic exercise training. J Appl Physiol 67: 1820-1826
Grichko VP, Heywood-Cooksey A, Kidd KRet al. (2000) Substrate profile in rat soleus muscle fibers after hindlimb unloading and fatigue. J Appl Physiol 88: 473-478
Grigoriev AI, Egorov AD (1991) The effects of prolonged spaceflights on the human body. Adv Space Biol Med 1: 1-35
Hargens AR, Whalen RT, Watenpaugh DEet al. (1991) Lower body negative pressure to provide load bearing in space. Aviat Space Environ Med 62: 934-937
Hather BM, Adams GR, Tesch PAet al. (1992) Skeletal muscle responses to lower limb suspension in humans. J Appl Physiol 72: 1493-1498
Hikida RS, Gollnick PD, Dudley GAet al. (1989) Structural and metabolic characteristics of human skeletal muscle following 30 days of simulated microgravity. Aviat Space Environ Med 60: 664-670
Hodgson JA, Bodine-Fowler SC, Roy RR et al. (1991) Changes in recruitment of rhesus soleus and gastrocnemius muscles following a 14 day spaceflight. Physiologist 34: S102-103
Howard JD, Enoka RM (1991) Maximum bilateral contractions are modified by neurally mediated interlimb effects. J Appl Physiol 70: 306-316
Jasperse JL, Woodman CR, Price EMet al. (1999) Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol 87: 1476-1482
Jiang B, Roy RR, Navarro Cet al. (1993) Absence of a growth hormone effect on rat soleus atrophy during a 4-day spaceflight. J Appl Physiol 74: 527-531
Kasper CE (1995) Sarcolemmal disruption in reloaded atrophic skeletal muscle. J Appl Physiol 79: 607-614
Kawakami Y, Muraoka Y, Kubo Ket al. (2000) Changes in muscle size and architecture following 20 days of bed rest. J Gravit Physiol 7: 53-59
Koryak Y (1998) Effect of 120 days of bed-rest with and without countermeasures on the mechanical properties of the triceps surae muscle in young women. Eur J Appl Physiol Occup Physiol 78: 128-135
Lackner JR, Graybiel A (1986) Head movements in non-terrestrial force environments elicit motion sickness: implications for the etiology of space motion sickness. Aviat Space Environ Med 57: 443-448
Larsson L, Li X, Berg HE, Frontera WR (1996) Effects of removal of weight-bearing function on contractility and myosin isoform composition in single human skeletal muscle cells. Pflugers Arch 432: 320-328
LeBlanc A, Gogia P, Schneider V et al. (1988) Calf muscle area and strength changes after five weeks of horizontal bed rest. Am J Sports Med 16: 624-629
LeBlanc A, Rowe R, Evans H et al. (1997) Muscle atrophy during long duration bed rest. Int J Sports Med 18 Suppl 4: S283-285
Lee SM, Bennett BS, Hargens AR et al. (1997) Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. Med Sci Sports Exerc 29: 892-900
Loughna PT, Goldspink DF, Goldspink G (1987) Effects of hypokinesia and hypodynamia upon protein turnover in hindlimb muscles of the rat. Aviat Space Environ Med 58: A133-138
Macias BR, Groppo ER, Eastlack RK et al. (2005) Space exercise and Earth benefits. Curr Pharm Biotechnol 6: 305-317
Maganaris CN, Reeves ND, Rittweger J et al. (2006) Adaptive response of human tendon to paralysis. Muscle Nerve 33: 85-92
McDonald KS, Delp MD, Fitts RH (1992) Fatigability and blood flow in the rat gastrocnemius-plantaris-soleus after hindlimb suspension. J Appl Physiol 73: 1135-1140
McDonald KS, Fitts RH (1995) Effect of hindlimb unloading on rat soleus fiber force, stiffness, and calcium sensitivity. J Appl Physiol 79: 1796-1802
Milesi S, Capelli C, Denoth Jet al. (2000) Effects of 17 days bedrest on the maximal voluntary isometric torque and neuromuscular activation of the plantar and dorsal flexors of the ankle. Eur J Appl Physiol 82: 197-205
Musacchia XJ, Steffen JM, Fell RD et al. (1992) Skeletal muscle atrophy in response to 14 days of weightlessness: vastus medialis. J Appl Physiol 73: 44S-50S
Narici M, Cerretelli P (1998) Changes in human muscle architecture in disuse-atrophy evaluated by ultrasound imaging. J Gravit Physiol 5: P73-74
Narici M, Kayser B, Barattini Pet al. (2003) Effects of 17-day spaceflight on electrically evoked torque and cross-sectional area of the human triceps surae. Eur J Appl Physiol 90: 275-282
Narici MV, Kayser B, Barattini Pet al. (1997) Changes in electrically evoked skeletal muscle contractions during 17-day spaceflight and bed rest. Int J Sports Med 18 Suppl 4: S290-292
Narici MV, Maganaris CN (2006) Adaptability of elderly human muscles and tendons to increased loading. J Anat 208: 433-443
Ohira Y, Jiang B, Roy RR et al. (1992) Rat soleus muscle fiber responses to 14 days of spaceflight and hindlimb suspension. J Appl Physiol 73: 51S-57S
Ohira Y, Yoshinaga T, Ohara M et al. (1999) Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading. J Appl Physiol 87: 1776-1785
Reeves ND, Maganaris CN, Ferretti Get al. (2005) Influence of 90-day simulated microgravity on human tendon mechanical properties and the effect of resistive countermeasures. J Appl Physiol 98: 2278-2286
Reeves NJ, Maganaris CN, Ferretti Get al. (2002) Influence of simulated microgravity on human skeletal muscle architecture and function. J Gravit Physiol 9: P153-154
Riley DA, Bain JL, Thompson JL et al. (2000) Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight. J Appl Physiol 88: 567-572
Riley DA, Ellis S, Giometti CS et al. (1992) Muscle sarcomere lesions and thrombosis after spaceflight and suspension unloading. J Appl Physiol 73: 33S-43S
Riley DA, Thompson JL, Krippendorf BBet al. (1995) Review of spaceflight and hindlimb suspension unloading induced sarcomere damage and repair. Basic Appl Myol 5: 139-145
Rittweger J, Frost HM, Schiessl H et al. (2005) Muscle atrophy and bone loss after 90 days’ bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Bone 36: 1019-1029
Roubenoff R (2001) Origins and clinical relevance of sarcopenia. Can J Appl Physiol 26: 78-89
Roy RR, Bello MA, Bouissou Pet al. (1987) Size and metabolic properties of fibers in rat fast-twitch muscles after hindlimb suspension. J Appl Physiol 62: 2348-2357
Rudnick J, Puttmann B, Tesch PA et al. (2004) Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest. Faseb J 18: 1228-1230
Schneider SM, Watenpaugh DE, Lee SM et al. (2002) Lower-body negative-pressure exercise and bed-rest-mediated orthostatic intolerance. Med Sci Sports Exerc 34: 1446-1453
Stein T, Schluter M, Galante A et al. (2002) Energy metabolism pathways in rat muscle under conditions of simulated microgravity. J Nutr Biochem 13: 471
Stein TP, Leskiw MJ, Schluter MDet al. (1999) Protein kinetics during and after long-duration spaceflight on MIR. Am J Physiol 276: E1014-1021
Suzuki Y, Kashihara H, Takenaka K et al. (1994) Effects of daily mild supine exercise on physical performance after 20 days bed rest in young persons. Acta Astronautica 33: 101-111
Talmadge RJ (2000) Myosin heavy chain isoform expression following reduced neuromuscular activity: potential regulatory mechanisms. Muscle Nerve 23: 661-679
Talmadge RJ, Roy RR, Edgerton VR (1999) Persistence of hybrid fibers in rat soleus after spinal cord transection. Anat Rec 255: 188-201
Templeton GH, Padalino M, Manton J et al. (1984) Influence of suspension hypokinesia on rat soleus muscle. J Appl Physiol 56: 278-286
Tesch PA, Berg HE (1997) Resistance training in space. Int J Sports Med 18 Suppl 4: S322-324
Tesch PA, Trieschmann JT, Ekberg A (2004) Hypertrophy of chronically unloaded muscle subjected to resistance exercise. J Appl Physiol 96: 1451-1458
Thomason DB, Biggs RB, Booth FW (1989) Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle. Am J Physiol 257: R300-305
Thomason DB, Booth FW (1990) Atrophy of the soleus muscle by hindlimb unweighting. J Appl Physiol 68: 1-12
Tischler ME, Henriksen EJ, Munoz KA et al. (1993) Spaceflight on STS-48 and earth-based unweighting produce similar effects on skeletal muscle of young rats. J Appl Physiol 74: 2161-2165
Trappe S, Trappe T, Gallagher P et al. (2004) Human single muscle fiber function with 84 day bed-rest and resistance exercise. J Physiol 557: 501-513
Vandenburgh H, Chromiak J, Shansky Jet al. (1999) Space travel directly induces skeletal muscle atrophy. Faseb J 13: 1031-1038
Vijayan K, Thompson JL, Norenberg KMet al. (2001) Fiber-type susceptibility to eccentric contraction-induced damage of hindlimb-unloaded rat AL muscles. J Appl Physiol 90: 770-776
Vijayan K, Thompson JL, Riley DA (1998) Sarcomere lesion damage occurs mainly in slow fibers of reloaded rat adductor longus muscles. J Appl Physiol 85: 1017-1023
Widrick JJ, Knuth ST, Norenberg KM et al. (1999) Effect of a 17 day spaceflight on contractile properties of human soleus muscle fibers. J Physiol 516: 915-930
Widrick JJ, Trappe SW, Romatowski JG et al. (2002) Unilateral lower limb suspension does not mimic bed rest or spaceflight effects on human muscle fiber function. J Appl Physiol 93: 354-360
Yamashita-Goto K, Okuyama R, Honda M et al. (2001) Maximal and submaximal forces of slow fibers in human soleus after bed rest. J Appl Physiol 91: 417-424
Yoshida N, Sairyo K, Sasa T et al. (2003) Electrical stimulation prevents deterioration of the oxidative capacity of disuse-atrophied muscles in rats. Aviat Space Environ Med 74: 207-211
Zange J, Muller K, Gerzer Ret al. (1996) Nongenomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise. J Clin Endocrinol Metab 81: 4296-4300
Zange J, Muller K, Schuber M et al. (1997) Changes in calf muscle performance, energy metabolism, and muscle volume caused by long-term stay on space station MIR. Int J Sports Med 18 Suppl 4: S308-309
Zhang LF, Sun B, Cao XS et al. (2003) Effectiveness of intermittent -Gx gravitation in preventing deconditioning due to simulated microgravity. J Appl Physiol 95: 207-218
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Narici, M., Zange, J., Di Prampero, P. (2007). Physiological Targets of Artificial Gravity: The Neuromuscular System. In: Clément, G., Bukley, A. (eds) Artificial Gravity. The Space Technology Library, vol 20. Springer, New York, NY. https://doi.org/10.1007/0-387-70714-X_6
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