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TRP Channels

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Biological Membrane Ion Channels

Part of the book series: Biological And Medical Physics Biomedical Engineering ((BIOMEDICAL))

Abstract

The TRP superfamily represents a highly diverse group of cation-permeable ion channels related to the product of the Drosophila trp (transient receptor potential) gene. The cloning and characterization of members of this cation channel family has experienced a remarkable growth during the last decade, uncovering a wealth of information concerning the role of TRP channels in a variety of cell types, tissues, and species. Initially, TRP channels were mainly considered as phospholipase C (PLC)-dependent and/or store-operated Ca2+-permeable cation channels. More recent research has highlighted the sensitivity of TRP channels to a broad array of chemical and physical stimuli, allowing them to function as dedicated biological sensors involved in processes ranging from vision to taste, tactile sensation, and hearing. Moreover, the tailored selectivity of certain TRP channels enables them to play key roles in the cellular uptake and/or transepithelial transport of Ca2+, Mg2+, and trace metal ions. In this chapter we give a brief overview of the TRP channel superfamily followed by a survey of current knowledge concerning their structure and activation mechanisms.

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Authors and Affiliations

  1. Laboratorium voor Fysiologie, Onderwijs en Navorsing Gasthuisberg KU Leuven, Herestraat 49 bus 802, Leuven, B-300, Belgium

    Thomas Voets

  2. Laboratorium voor Fysiologie Campus Gasthuisberg, O&N 1 Herestraat 40, Bus 802 KU Leuven, Leuven, B-300, Belgium

    Grzegorz Owsianik

  3. Laboratorium voor Fysiologie Campus Gasthuisberg, O&N 1 Herestraat 40, Bus 802 KU Leuven, Leuven, B-300, Belgium

    Bernd Nilius

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  2. Grzegorz Owsianik
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  1. Res. School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia

    Shin-Ho Chung

  2. Weill Medical College Dept. Physiology, Cornell University, 1300 York Avenue, New York, NY, 10021, USA

    Olaf S. Andersen

  3. Dept. of Elect. & Comp. Engi., University of British Columbia, MacLeod Bulding, Vancouver, BC, Canada

    Vikram Krishnamurthy

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Voets, T., Owsianik, G., Nilius, B. (2007). TRP Channels. In: Chung, SH., Andersen, O.S., Krishnamurthy, V. (eds) Biological Membrane Ion Channels. Biological And Medical Physics Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/0-387-68919-2_11

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