Skip to main content
SpringerLink
Log in

Memory B Cell Evolution: B Cell Biology

  • Conference paper
Mechanisms of Lymphocyte Activation and Immune Regulation XI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 596))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A. Aderem and R. J. Ulevitch, Toll-like receptors in the induction of the innate immune response, Nature 406, 782–7 (2000)

    Article  PubMed  CAS  Google Scholar 

  2. C. A. Janeway, Jr. and R. Medzhitov, Innate immune recognition, Annu Rev Immunol 20, 197–216 (2002)

    Article  PubMed  CAS  Google Scholar 

  3. J. Banchereau and R. M. Steinman, Dendritic cells and the control of immunity, Nature 392, 245–52 (1998)

    Article  PubMed  CAS  Google Scholar 

  4. K. Shortman and Y. J. Liu, Mouse and human dendritic cell subtypes, Nat Rev Immunol 2, 151–61 (2002)

    Article  PubMed  CAS  Google Scholar 

  5. J. L. Jorgensen, U. Esser, B. Fazekas de St Groth, P. A. Reay and M. M. Davis, Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics, Nature 355, 224–30 (1992)

    Article  PubMed  CAS  Google Scholar 

  6. M. G. McHeyzer-Williams and M. M. Davis, Antigen-specific development of primary and memory T cells in vivo, Science 268, 106–11 (1995)

    Article  PubMed  CAS  Google Scholar 

  7. S. M. Alam, P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson and N. R. Gascoigne, T-cell-receptor affinity and thymocyte positive selection, Nature 381, 616–20 (1996)

    Article  PubMed  CAS  Google Scholar 

  8. D. H. Busch and E. G. Pamer, T cell affinity maturation by selective expansion during infection, J Exp Med 189, 701–10 (1999)

    Article  PubMed  CAS  Google Scholar 

  9. M. Fasso, N. Anandasabapathy, F. Crawford, J. Kappler, C. G. Fathman and W. M. Ridgway, T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo, J Exp Med 192, 1719–30 (2000)

    Article  PubMed  CAS  Google Scholar 

  10. L. Malherbe, C. Filippi, V. Julia, G. Foucras, M. Moro, H. Appel, K. Wucherpfennig, J. C. Guery and N. Glaichenhaus, Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major, Immunity 13, 771–82 (2000)

    Article  PubMed  CAS  Google Scholar 

  11. R. M. Kedl, W. A. Rees, D. A. Hildeman, B. Schaefer, T. Mitchell, J. Kappler and P. Marrack, T cells compete for access to antigen-bearing antigen-presenting cells, J Exp Med 192, 1105–13 (2000)

    Google Scholar 

  12. R. M. Kedl, B. C. Schaefer, J. W. Kappler and P. Marrack, T cells down-modulate peptide-MHC complexes on APCs in vivo, Nat Immunol 3, 27–32 (2002)

    Article  PubMed  CAS  Google Scholar 

  13. G. J. Kersh, E. N. Kersh, D. H. Fremont and P. M. Allen, High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling, Immunity 9, 817–26 (1998)

    Article  PubMed  CAS  Google Scholar 

  14. D. S. Lyons, S. A. Lieberman, J. Hampl, J. J. Boniface, Y. Chien, L. J. Berg and M. M. Davis, A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists, Immunity 5, 53–61 (1996)

    Article  PubMed  CAS  Google Scholar 

  15. K. Matsui, J. J. Boniface, P. Steffner, P. A. Reay and M. M. Davis, Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness, Proc Natl Acad Sci U S A 91, 12862–6 (1994)

    Article  PubMed  CAS  Google Scholar 

  16. P. A. Savage, J. J. Boniface and M. M. Davis, A kinetic basis for T cell receptor repertoire selection during an immune response, Immunity 10, 485–92 (1999)

    Article  PubMed  CAS  Google Scholar 

  17. P. A. Savage and M. M. Davis, A kinetic window constricts the T cell receptor repertoire in the thymus, Immunity 14, 243–52 (2001)

    Article  PubMed  CAS  Google Scholar 

  18. L. Malherbe, C. Hausl, L. Teyton and M. G. McHeyzer-Williams, Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties, Immunity 21, 669–79 (2004)

    Article  PubMed  CAS  Google Scholar 

  19. M. Balazs, F. Martin, T. Zhou and J. Kearney, Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses, Immunity 17, 341–52 (2002)

    Article  PubMed  CAS  Google Scholar 

  20. A. Bergtold, D. D. Desai, A. Gavhane and R. Clynes, Cell surface recycling of internalized antigen permits dendritic cell priming of B cells, Immunity 23, 503–14 (2005)

    Article  PubMed  CAS  Google Scholar 

  21. F. D. Batista and M. S. Neuberger, Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate, Immunity 8, 751–9 (1998)

    Article  PubMed  CAS  Google Scholar 

  22. J. F. Panus, L. J. McHeyzer-Williams and M. G. McHeyzer-Williams, Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses, J Exp Med 192, 1301–16 (2000)

    Article  Google Scholar 

  23. L. J. McHeyzer-Williams and M. G. McHeyzer-Williams, Antigen-specific memory B cell development, Annu Rev Immunol 23, 487–513 (2005)

    Article  PubMed  CAS  Google Scholar 

  24. L. J. McHeyzer-Williams and M. G. McHeyzer-Williams, Developmentally distinct Th cells control plasma cell production in vivo, Immunity 20, 231–42 (2004)

    Article  PubMed  CAS  Google Scholar 

  25. G. Bikah, R. R. Pogue-Caley, L. J. McHeyzer-Williams and M. G. McHeyzer-Williams, Regulating T helper cell immunity through antigen responsiveness and calcium entry, Nat Immunol 1, 402–12 (2000)

    Article  PubMed  CAS  Google Scholar 

  26. J. Jacob, R. Kassir and G. Kelsoe, In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations, J Exp Med 173, 1165–75 (1991)

    Article  PubMed  CAS  Google Scholar 

  27. J. Jacob and G. Kelsoe, In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers, J Exp Med 176, 679–87 (1992)

    Article  PubMed  CAS  Google Scholar 

  28. J. Jacob, G. Kelsoe, K. Rajewsky and U. Weiss, Intraclonal generation of antibody mutants in germinal centres, Nature 354, 389–92 (1991)

    Article  PubMed  CAS  Google Scholar 

  29. M. G. McHeyzer-Williams, M. J. McLean, P. A. Lalor and G. J. V. Nossal, Antigen-driven B cell differentiation in vivo, J Exp Med 178, 295–307 (1993)

    Article  PubMed  CAS  Google Scholar 

  30. M. G. McHeyzer-Williams, G. J. V. Nossal and P. A. Lalor, Molecular characterization of single memory B cells, Nature 350, 502–5 (1991)

    Article  PubMed  CAS  Google Scholar 

  31. T. A. Shih, E. Meffre, M. Roederer and M. C. Nussenzweig, Role of BCR affinity in T cell dependent antibody responses in vivo, Nat Immunol 3, 570–5 (2002)

    Article  PubMed  Google Scholar 

  32. I. C. M. MacLennan, Germinal centers, Annu Rev Immunol 12, 117–39 (1994)

    Article  PubMed  CAS  Google Scholar 

  33. I. C. M. MacLennan and D. Gray, Antigen-driven selection of virgin and memory B cells, Immunol. Rev. 91, 61–85 (1986)

    Article  PubMed  CAS  Google Scholar 

  34. M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai and T. Honjo, Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme, Cell 102, 553–63 (2000)

    Article  PubMed  CAS  Google Scholar 

  35. N. Maizels, Immunoglobulin gene diversification, Annu Rev Genet 39, 23–46 (2005)

    Article  PubMed  CAS  Google Scholar 

  36. K. G. Smith, A. Light, L. A. O’Reilly, S. M. Ang, A. Strasser and D. Tarlinton, bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells, J Exp Med 191, 475–84 (2000)

    Article  PubMed  CAS  Google Scholar 

  37. Y. Takahashi, D. M. Cerasoli, J. M. Dal Porto, M. Shimoda, R. Freund, W. Fang, D. G. Telander, E. N. Malvey, D. L. Mueller, T. W. Behrens and G. Kelsoe, Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice, J Exp Med 190, 399–410 (1999)

    Article  PubMed  CAS  Google Scholar 

  38. Y. Takahashi, H. Ohta and T. Takemori, Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire, Immunity 14, 181–92 (2001)

    Article  PubMed  CAS  Google Scholar 

  39. M. H. Kosco-Vilbois, Are follicular dendritic cells really good for nothing?, Nat Rev Immunol 3, 764–9 (2003)

    Article  PubMed  CAS  Google Scholar 

  40. J. G. Tew, M. H. Kosco, G. F. Burton and A. K. Szakal, Follicular dendritic cells as accessory cells, Immunol Rev 117, 185–211 (1990)

    Article  PubMed  CAS  Google Scholar 

  41. D. J. Campbell, C. H. Kim and E. C. Butcher, Separable effector T cell populations specialized for B cell help or tissue inflammation, Nat Immunol 2, 876–81 (2001)

    Article  PubMed  CAS  Google Scholar 

  42. M. R. Tourigny, J. Ursini-Siegel, H. Lee, K. M. Toellner, A. F. Cunningham, D. S. Franklin, S. Ely, M. Chen, X. F. Qin, Y. Xiong, I. C. MacLennan and S. Chen-Kiang, CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells, Immunity 17, 179–89 (2002)

    Article  PubMed  CAS  Google Scholar 

  43. M. Shapiro-Shelef, K. I. Lin, L. J. McHeyzer-Williams, J. Liao, M. G. McHeyzer-Williams and K. Calame, Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells, Immunity 19, 607–20 (2003)

    Article  PubMed  CAS  Google Scholar 

  44. M. M. Winslow, E. M. Gallo, J. R. Neilson and G. R. Crabtree, The calcineurin phosphatase complex modulates immunogenic B cell responses, Immunity 24, 141–52 (2006)

    Article  PubMed  CAS  Google Scholar 

  45. A. Gulbranson-Judge and I. MacLennan, Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c, Eur J Immunol 26, 1830–7 (1996)

    Article  PubMed  CAS  Google Scholar 

  46. L. J. McHeyzer-Williams, J. Fanelli Panus, J. A. Mikszta and M. G. McHeyzer-Williams, Evolution of antigen-specific T cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs, Journal of Experimental Medicine 189, In Press (1999)

    Google Scholar 

  47. B. Zheng, S. Han and G. Kelsoe, T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1, J Exp Med 184, 1083–91 (1996)

    Article  PubMed  CAS  Google Scholar 

  48. J. A. Mikszta, L. J. McHeyzer-Williams and M. G. McHeyzer-Williams, Antigen-driven selection of TCR In vivo: related TCR alpha-chains pair with diverse TCR beta-chains, J Immunol 163, 5978–88 (1999)

    PubMed  CAS  Google Scholar 

  49. M. G. McHeyzer-Williams and R. Ahmed, B cell memory and the long-lived plasma cell, Curr. Opin. Immunol. 11, 172–9 (1999)

    Article  PubMed  CAS  Google Scholar 

  50. B. Schittek and K. Rajewsky, Maintenance of B-cell memory by long-lived cells generated from proliferating precursors, Nature 346, 749–51 (1990)

    Article  PubMed  CAS  Google Scholar 

  51. M. Maruyama, K. P. Lam and K. Rajewsky, Memory B-cell persistence is independent of persisting immunizing antigen, Nature 407, 636–42 (2000)

    Article  PubMed  CAS  Google Scholar 

  52. K. Hayakawa, R. Ishii, K. Yamasaki, T. Kishimoto and R. R. Hardy, Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells, Proc Natl Acad Sci U S A 84, 1379–83 (1987)

    Article  PubMed  CAS  Google Scholar 

  53. M. H. Julius, T. Masuda and L. A. Herzenberg, Demonstration that antigen-binding cells are precursors of antibody-producing cells after purification with a fluorescence-activated cell sorter, Proc Natl Acad Sci U S A 69, 1934–8 (1972)

    Article  PubMed  CAS  Google Scholar 

  54. E. J. Blink, A. Light, A. Kallies, S. L. Nutt, P. D. Hodgkin and D. M. Tarlinton, Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization, J Exp Med 201, 545–54 (2005)

    Article  PubMed  CAS  Google Scholar 

  55. L. J. McHeyzer-Williams, M. Cool and M. G. McHeyzer-Williams, Antigen-specific B cell memory: expression and replenishment of a novel B220- memory b cell compartment, J Exp Med 191, 1149–66 (2000)

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Louise J. McHeyzer-Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael G. McHeyzer-Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine, College of Health Sciences, University of California, Irvine, CA 92697, USA

    Sudhir Gupta

  2. Department of Genetics, Children's Hospital Boston, Boston, MA 02115, USA

    Frederick Alt

  3. Inst. Medical/Tumor Research Laboratories, University of Alabama, Birmingham, AL 35294, USA

    Max Cooper

  4. BiozentrumAbt. Zellbiologie, Max Planck Institute for Infection Biology, Berlin, 4056, Germany

    Fritz Melchers

  5. Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA

    Klaus Rajewsky

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this paper

Cite this paper

McHeyzer-Williams, L.J., McHeyzer-Williams, M.G. (2007). Memory B Cell Evolution: B Cell Biology. In: Gupta, S., Alt, F., Cooper, M., Melchers, F., Rajewsky, K. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation XI. Advances in Experimental Medicine and Biology, vol 596. Springer, Boston, MA. https://doi.org/10.1007/0-387-46530-8_3

Download citation

Publish with us

Policies and ethics

Search

Navigation