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Does Ventilator-induced Lung Injury Initiate Non-pulmonary Organ Dysfunction?

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Intensive Care Medicine

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Abstract

The mortality rate and costs associated with acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), remain excessively high [1]. Although the most obvious clinical abnormalities in ALI/ARDS are referable to the lung, the most common cause of death is not due to hypoxia but to multiple organ dysfunction syndrome (MODS) [2]. MODS is often irreversible with a mortality rate higher than 60%. We currently lack a specific treatment of the syndrome and modern technology, such as hemodialysis, only allows temporary substitution of organ function, providing a bridge to recovery. Better understanding of the pathophysiology leading to the development of MODS in mechanically ventilated patients should help in the development of approaches to interrupt the cascades leading to MODS.

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Author information

Authors and Affiliations

  1. Department of Critical Care Medicine, University Hospital-Inselspital, Bern, Switzerland

    L. Brander

  2. Department of Critical Care Medicine, St. Michael’s Hospital, 30 Bond St, Queen Wing, Room 4-042, Toronto, ON, MB 1W, Canada

    A. S. Slutsky

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  1. L. Brander
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  2. A. S. Slutsky
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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© 2006 Springer Science + Business Media Inc.

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Brander, L., Slutsky, A.S. (2006). Does Ventilator-induced Lung Injury Initiate Non-pulmonary Organ Dysfunction?. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/0-387-35096-9_39

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  • DOI: https://doi.org/10.1007/0-387-35096-9_39

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-30156-3

  • Online ISBN: 978-0-387-35096-7

  • eBook Packages: MedicineMedicine (R0)

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