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Cell-Bound Complement Activation Products (CB-CAPs) as a Source of Lupus Biomarkers

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Current Topics in Complement

Part of the book series: Advances in Experimental Medicine and Biology ((volume 586))

4. Summary

Measurement of serum C3 and C4 has been used for several decades to monitor disease activity in patients with SLE. Despite the limited utility and recognized weaknesses of these assays, they have remained the gold standard during an era of unprecedented discovery in the complement field. The current urgent need for lupus biomarkers warrants efforts to mine the complement system for assays superior to serum C3 and C4. Recent studies of soluble and cell-bound complement activation products hold promise for achieving this goal.

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Authors and Affiliations

  1. Lupus Center of Excellence, University of Pittsburgh School of Medicine and the University of Pittsburgh Graduate School of Public Health, USA

    Sarah J. Calano, Pei-an B. Shih, Chau-Ching Liu, Amy H. Kao, Jeannine S. Navratil, Susan Manzi & Joseph M. Ahearn

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  1. Sarah J. Calano
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  2. Pei-an B. Shih
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Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, PA, 19107

    John D. Lambris Ph.D. (Professor of Pathology & Laboratory Medicine) (Professor of Pathology & Laboratory Medicine)

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Calano, S.J. et al. (2006). Cell-Bound Complement Activation Products (CB-CAPs) as a Source of Lupus Biomarkers. In: Lambris, J.D. (eds) Current Topics in Complement. Advances in Experimental Medicine and Biology, vol 586. Springer, Boston, MA. https://doi.org/10.1007/0-387-34134-X_25

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