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Liver Regeneration: A Link to Inflammation through Complement

  • Conference paper
Current Topics in Complement

Part of the book series: Advances in Experimental Medicine and Biology ((volume 586))

4. Conclusion

We have emphasized here the similarities that exist between the inflammatory and regenerative responses in terms of mediators involved, providing evidence that liver regeneration includes an inflammatory reaction. Particular emphasis has been placed on the role of complement, an early and fundamental player in innate immunity, in regeneration of the liver. During the inflammatory response there are multiple interactions existing between several complement proteins and the network of pleiotropic mediators, the cytokines. Through cytokine functions, complement is involved in precise and balanced regulation of innate and adaptive immune responses and the control of cellular growth and apoptosis. Additionally, through cytokine signaling and other, more direct processes, complement is now known to be vital for proper liver regeneration. Thus, the interactions between various complement proteins and cytokines are essential for both immune responses and tissue regeneration, and provide a new link in the expanding chain connecting these two biological phenomena.

These authors contributed equally to this work.

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  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA, 19104

    Robert A. DeAngelis, Maciej M. Markiewski & John D. Lambris

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  1. Robert A. DeAngelis
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  2. Maciej M. Markiewski
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  1. University of Pennsylvania, Philadelphia, PA, 19107

    John D. Lambris Ph.D. (Professor of Pathology & Laboratory Medicine) (Professor of Pathology & Laboratory Medicine)

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DeAngelis, R.A., Markiewski, M.M., Lambris, J.D. (2006). Liver Regeneration: A Link to Inflammation through Complement. In: Lambris, J.D. (eds) Current Topics in Complement. Advances in Experimental Medicine and Biology, vol 586. Springer, Boston, MA. https://doi.org/10.1007/0-387-34134-X_2

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