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Overview of Role of the Immune System in the Pathogenesis of Inflammatory Bowel Disease

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Book cover Immune Mechanisms in Inflammatory Bowel Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 579))

Abstract

Crohn’s disease (CD) and ulcerative colitis (UC) are caused by the over-activity of the immune system. Current and novel therapies are designed to dampen these over-active responses. Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases. The former has the molecular imprints of a Th1 dominant cell-mediated hypersensitivity response whereas the latter appears to involve antibody-mediated hypersensitivity.

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Author information

Authors and Affiliations

  1. University of Southampton School of Medicine, Southhampton, UK

    Thomas T. MacDonald

  2. Department of Gastroenterology, University Tor Vergata, Rome, Italy

    Giovanni Monteleone

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  1. Thomas T. MacDonald
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  2. Giovanni Monteleone
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Editors and Affiliations

  1. Gastroenterology Division and Laboratory of Mucosal Immunology, Brigham and Women’s Hospital, Harvard, Massachusetts, USA

    Richard S. Blumberg

  2. 1st Department of Medicine, Johannes-Gutenberg-University, Mainz, Germany

    Markus F. Neurath

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MacDonald, T.T., Monteleone, G. (2006). Overview of Role of the Immune System in the Pathogenesis of Inflammatory Bowel Disease. In: Blumberg, R.S., Neurath, M.F. (eds) Immune Mechanisms in Inflammatory Bowel Disease. Advances in Experimental Medicine and Biology, vol 579. Springer, New York, NY. https://doi.org/10.1007/0-387-33778-4_6

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