The Role of Inflammation and Infection in the Development of Chronic Lung Disease of Prematurity

  • Philip L. Davies
  • Nicola C. Maxwell
  • Sailesh Kotecha
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 582)

8. Summary

CLD is a significant cause of infant morbidity and mortality. The lung injury is multifactorial in origin with supplemental oxygen and ventilatory damage being only part of the picture. Antenatal and postnatal infection and inflammation are also important in the development of CLD, although their precise role has still to be fully ascertained.

In the future, therapeutic strategies need to be considered to decrease the incidence and severity of CLD. In particular a definitive trial investigating the role of antibiotics against Ureaplasma urealyticum in preventing CLD needs to be performed. Increased use of newer microbiological methods will also improve our understanding of the role of infection in CLD and further guide research and clinical management.


Respiratory Distress Syndrome Patent Ductus Arteriosus Preterm Delivery Chronic Lung Disease Bronchopulmonary Dysplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Philip L. Davies
    • 1
  • Nicola C. Maxwell
    • 1
  • Sailesh Kotecha
    • 1
  1. 1.Department of Child HealthCardiff UniversityCardiffUK

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