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Controversies in Neonatal Sepsis: Immunomodulation in the Treatment and Prevention of Neonatal Sepsis

  • Samantha J. Moss
  • Andrew R. Gennery
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 582)

6. Conclusion

Whilst the concept of replacing the neonatal immunological deficit to prevent or treat systemic sepsis is theoretically attractive, the results from clinical trials performed to date are perhaps less dramatic than expected. The reasons for this are likely to be multifactorial, but include the recruitment of low risk infants who are not septic or neutropenic, and use of inappropriate immunoglobulin preparations that contains little or no antibody effective against pathogens causing neonatal sepsis. There may well be cheaper, more effective, but less glamorous, methods of preventing infection in the preterm infant. There is accumulating evidence regarding the role of prophylactic broad spectrum antibiotics on neonatal gut flora and the influence of early enteral feeding with a correct milk formula can have on encouraging “friendly” gut bacteria. The role of growth factors and immunoglobulin preparations in the treatment and prophylaxis of neonatal sepsis has not yet been established and these products should only be used in the context of large randomised controlled clinical trials until there is clear evidence of benefit (or absence of benefit) in their use.

Keywords

Neonatal Intensive Care Unit Intravenous Immunoglobulin Coagulase Negative Staphylococcus Neonatal Sepsis Granulocyte Transfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Samantha J. Moss
    • 1
  • Andrew R. Gennery
    • 2
  1. 1.Neonatal DepartmentRoyal Victoria InfirmaryNewcastle upon TyneUK
  2. 2.Paediatric Immunology DepartmentNewcastle General HospitalNewcastle upon TyneUK

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