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How Do We Treat Children with Severe Malaria?

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Hot Topics in Infection and Immunity in Children III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 582))

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References

  • (1997). “Pediatric Advanced Life Support 1997–1999.” American Heart Association, Dallas, Texas.

    Google Scholar 

  • (2000). Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 94Suppl 1, S1–90.

    Google Scholar 

  • Allen, S.J., O’Donnell, A., Alexander, N.D., and Clegg, J.B. (1996). Severe malaria in children in Papua New Guinea. Q J Med 89, 779–88.

    CAS  Google Scholar 

  • Bradley, D. (2003). Illness in England, Wales, and Northern Ireland associated with foreign travel: A baseline report to 2002. pp. 48–55. Travel Health Surveillance Section, London.

    Google Scholar 

  • Crawley, J., Smith, S., Kirkham, F., Muthinji, P., Waruiru, C., and Marsh, K. (1996). Seizures and status epilepticus in childhood cerebral malaria. Q J Med 89, 591–7.

    CAS  Google Scholar 

  • Crawley, J., Waruiru, C., Mithwani, S., Mwangi, I., Watkins, W., Ouma, D., Winstanley, P., Peto, T., and Marsh, K. (2000). Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. Lancet 355, 701–6.

    Article  PubMed  CAS  Google Scholar 

  • Day, N.P., Phu, N.H., Mai, N.T., Chau, T.T., Loc, P.P., Chuong, L.V., Sinh, D.X., Holloway, P., Hien, T.T., and White, N.J. (2000). The pathophysiologic and prognostic significance of acidosis in severe adult malaria. Crit Care Med 28, 1833–40.

    Article  PubMed  CAS  Google Scholar 

  • Group, A.L.S. (2001). “Advanced Paediatric Life support: The practical approach.” BMJ Publishing Group, London.

    Google Scholar 

  • Guerin, P.J., Olliaro, P., Nosten, F., Druilhe, P., Laxminarayan, R., Binka, F., Kilama, W.L., Ford, N., and White, N.J. (2002). Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis 2, 564–73.

    Article  PubMed  Google Scholar 

  • Herson, V.C., and Todd, J.K. (1977). Prediction of morbidity in Hemophilus influenzae meningitis. Pediatrics 59, 35–9.

    PubMed  CAS  Google Scholar 

  • Idro, R., Karamagi, C., and Tumwine, J. (2004). Immediate outcome and prognostic factors for cerebral malaria among children admitted to Mulago Hospital, Uganda. Ann Trop Paediatr 24, 17–24.

    Article  PubMed  Google Scholar 

  • Ladhani, S., El Bashir, H., Patel, V.S., and Shingadia, D. (2003). Childhood malaria in East London. Pediatr Infect Dis J 22, 814–19.

    Article  PubMed  Google Scholar 

  • Lewallen, S., Harding, S.P., Ajewole, J., Schulenburg, W.E., Molyneux, M.E., Marsh, K., Usen, S., White, N.J., and Taylor, T.E. (1999). A review of the spectrum of clinical ocular fundus findings in P. falciparum malaria in African children with a proposed classification and grading system. Trans R Soc Trop Med Hyg 93, 619–22.

    Article  PubMed  CAS  Google Scholar 

  • Lewallen, S., White, V.A., Whitten, R.O., Gardiner, J., Hoar, B., Lindley, J., Lochhead, J., McCormick, A., Wade, K., Tembo, M., Mwenechanyana, J., Molyneux, M.E., and Taylor, T.E. (2000). Clinicalhistopathological correlation of the abnormal retinal vessels in cerebral malaria. Arch Ophthalmol 118, 924–8.

    PubMed  CAS  Google Scholar 

  • Lewallen, S.W., Whitten, V.A., Gardiner, R.O., Hoar, J., Lindley, B., Lochhead, J., McCormick, J., Wade, A., Tembo, K., Mwenechanyana, M., Molyneux, J., Taylor, ME., TE. (2000). Clinical-histopathological correlation of the abnormal retinal vessels in cerebral malaria. Arch Ophthalmol 118, 924–8.

    PubMed  CAS  Google Scholar 

  • Maitland, K., Levin, M., English, M., Mithwani, S., Peshu, N., Marsh, K., and Newton, C.R. (2003a). Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia. Q J med 96, 427–34.

    CAS  Google Scholar 

  • Maitland, K., Nadel, S., Pollard, A.J., Williams, T.N., Newton, C.R., and Levin, M. (2005a). Management of severe malaria in children: proposed guidelines for the United Kingdom. BMJ 331, 337–43.

    Article  PubMed  Google Scholar 

  • Maitland, K., and Newton, C.R. (2005). Acidosis of severe falciparum malaria: heading for a shock? Trends Parasitol 21, 11–16.

    Article  PubMed  Google Scholar 

  • Maitland, K., Pamba, A., English, M., Peshu, N., Levin, M., Marsh, K., and Newton, C.R. (2005b). Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion. Br J Haematol 128, 393–400.

    Article  PubMed  Google Scholar 

  • Maitland, K., Pamba, A., English, M., Peshu, N., Marsh, K., Newton, C.R.J.C., and Levin, M. (2005c). Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clin Infect Dis 40, 538–45.

    Article  PubMed  Google Scholar 

  • Maitland, K., Pamba, A., Fegan, G., Njuguna, P., Nadel, S., Newton, C.R., and Lowe, B. (2005d). Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis. Clin Infect Dis 40, 9–16.

    Article  PubMed  Google Scholar 

  • Maitland, K., Pamba, A., Newton, C.R., and Levin, M. (2003b). Response to volume resuscitation in children with severe malaria. Pediatr Crit Care Med 4, 426–31.

    Article  PubMed  Google Scholar 

  • Molyneux, M.E., Taylor, T.E., Wirima, J.J., and Borgstein, A. (1989). Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71, 441–59.

    PubMed  CAS  Google Scholar 

  • Moody, A.H., and Chiodini, P.L. (2002). Non-microscopic method for malaria diagnosis using OptiMAL IT, a second-generation dipstick for malaria pLDH antigen detection. Br J Biomed Sci 59, 228–31.

    PubMed  CAS  Google Scholar 

  • Newton, C.R., Crawley, J., Sowumni, A., Waruiru, C., Mwangi, I., English, M., Murphy, S., Winstanley, P.A., Marsh, K., and Kirkham, F.J. (1997). Intracranial hypertension in Africans with cerebral malaria. Arch Dis Child 76, 219–26.

    Article  PubMed  CAS  Google Scholar 

  • Newton, C.R., Kirkham, F.J., Winstanley, P.A., Pasvol, G., Peshu, N., Warrell, D.A., and Marsh, K. (1991a). Intracranial pressure in African children with cerebral malaria. Lancet 337, 573–6.

    Article  PubMed  CAS  Google Scholar 

  • Newton, C.R., Kirkham, F.J., Winstanley, P.A., Pasvol, G., Peshu, N., Warrell, D.A., and Marsh, K. (1991b). Intracranial pressure in African children with cerebral malaria. Lancet 337, 573–6.

    Article  PubMed  CAS  Google Scholar 

  • Newton, C.R., and Krishna, S. (1998). Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther 79, 1–53.

    Article  PubMed  CAS  Google Scholar 

  • Newton, C.R., Taylor, T.E., and Whitten, R.O. (1998). Pathophysiology of fatal falciparum malaria in African children. Am J Trop Med Hyg 58, 673–83.

    PubMed  CAS  Google Scholar 

  • Palmer, C.J., Bonilla, J.A., Bruckner, D.A., Barnett, E.D., Miller, N.S., Haseeb, M.A., Masci, J.R., and Stauffer, W.M. (2003). Multicenter study to evaluate the OptiMAL test for rapid diagnosis of malaria in U.S. hospitals. J Clin Microbiol 41, 5178–82.

    Article  PubMed  Google Scholar 

  • Pamba, A., and Maitland, K. (2004). Capillary refill: prognostic value in Kenyan children. Arch Dis Child 89, 950–5.

    Article  PubMed  CAS  Google Scholar 

  • Powell, K.R., Sugarman, L.I., Eskenazi, A.E., Woodin, K.A., Kays, M.A., McCormick, K.L., Miller, M.E., and Sladek, C.D. (1990). Normalization of plasma arginine vasopressin concentrations when children with meningitis are given maintenance plus replacement fluid therapy. J Pediatr 117, 515–22.

    Article  PubMed  CAS  Google Scholar 

  • Riddle, M.S., Jackson, J.L., Sanders, J.W., and Blazes, D.L. (2002). Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis. Clin Infect Dis 34, 1192–8.

    Article  PubMed  Google Scholar 

  • Schmutzhard, E., and Gerstenbrand, F. (1984). Cerebral malaria in Tanzania. Its epidemiology, clinical symptoms and neurological long term sequelae in the light of 66 cases. Trans R Soc Trop Med Hyg 78, 351–3.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, T.E., Borgstein, A., and Molyneux, M.E. (1993). Acid-base status in paediatric Plasmodium falciparum malaria. Q J Med 86, 99–109.

    PubMed  CAS  Google Scholar 

  • Taylor, T.E., Fu, W.J., Carr, R.A., Whitten, R.O., Mueller, J.G., Fosiko, N.G., Lewallen, S., Liomba, N.G., and Molyneux, M.E. (2004). Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med 10, 143–5.

    Article  PubMed  CAS  Google Scholar 

  • Travel, H.S.S. (2003). Illness in England, Wales, and Northern Ireland associated with foreign travel: a baseline report to 2002. Health Protection Agency, London.

    Google Scholar 

  • Walker, O., Salako, L.A., Sowunmi, A., Thomas, J.O., Sodeine, O., and Bondi, F.S. (1992). Prognostic risk factors and post mortem findings in cerebral malaria in children. Trans R Soc Trop Med Hyg 86, 491–3.

    Article  PubMed  CAS  Google Scholar 

  • Waller, D., Crawley, J., Nosten, F., Chapman, D., Krishna, S., Craddock, C., Brewster, D., and White, N.J. (1991b). Intracranial pressure in childhood cerebral malaria. Trans R Soc Trop Med Hyg 85, 362–4.

    Article  PubMed  CAS  Google Scholar 

  • Waller, D., Krishna, S., Crawley, J., Miller, K., Nosten, F., Chapman, D., ter Kuile, F.O., Craddock, C., Berry, C., Holloway, P.A., et al. (1995). Clinical features and outcome of severe malaria in Gambian children. Clin Infect Dis 21, 577–87.

    PubMed  CAS  Google Scholar 

  • White, V.A., Lewallen, S., Beare, N., Kayira, K., Carr, R.A., and Taylor, T.E. (2001). Correlation of retinal haemorrhages with brain haemorrhages in children dying of cerebral malaria in Malawi. Trans R Soc Trop Med Hyg 95, 618–21.

    Article  PubMed  CAS  Google Scholar 

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Maitland, K. (2006). How Do We Treat Children with Severe Malaria?. In: Pollard, A.J., Finn, A. (eds) Hot Topics in Infection and Immunity in Children III. Advances in Experimental Medicine and Biology, vol 582. Springer, Boston, MA . https://doi.org/10.1007/0-387-33026-7_2

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