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The Polyomavirus, JCV, and Its Involvement in Human Disease

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Polyomaviruses and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

The human neurotropic polyomavirus, JC virus (JCV), is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients. JCV has also been found to be associated with human tumors of the brain and other organs. In this chapter, we describe JC virus and its role in human diseases.

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Authors and Affiliations

  1. Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania, USA

    Kamel Khalili Ph.D., Jennifer Gordon Ph.D. & Martyn K. White Ph.D.

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  1. Kamel Khalili Ph.D.
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  2. Jennifer Gordon Ph.D.
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  1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, Florida, USA

    Nasimul Ahsan M.D., FACP

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Khalili, K., Gordon, J., White, M.K. (2006). The Polyomavirus, JCV, and Its Involvement in Human Disease. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_20

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