Abstract
Epilepsy is a tendency of occurrence of transient recurrent abnormal electrical discharges in the brain affecting one or more of the following brain functions: motor, sensory, cognitive, speech, behavioral, emotional, and psychological. The lifetime prevalence of epilepsy in the general population is between 2 and 3%. The prevalence of epilepsy among people who have mental retardation is much higher. Although it is difficult to determine the exact figure, the reported prevalence of lifetime epilepsy among people with mental retardation (IQ< 70) varies between 13 and 24% (Deb, 1997a; Forsgren, Edvinsson, Blomquist, Heijbel, & Sidenvall, 1990; Goulden, Shinnar, Koller, Katz, & Richardson, 1991; McGrother, Hauck, Bhaumik, Thorp, & Taub, 1996; Rutter, Tizard, Yule, Graham, & Whitmore, 1976).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
REFERENCES
Alvarez, N. (1998). Barbiturates in the treatment of epilepsy in people with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 16–23.
Alvarez, N., Besag, F., & Livanianen, M. (1998). Use of antiepileptic drugs in the treatment of epilepsy in people with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 1–15.
Benedetti, B. D., Dov, I., Hauser, W. A., Shinnar, S., & Cohen, H. J. (1986). Frequency of seizures among children with cerebral palsy and mental retardation. Developmental Medical Child Neurology, 28(Suppl. 53), 36.
Ben-Menachem, E. (2000). New antiepileptic drugs and non-pharmacological treatments. Current Opinion in Neurology, 13, 165–170.
Ben-Menachem, E., Henriksen, O., & Johannessen, S. I. (1999). Diagnosis and treatment of partial seizures. CNS Drugs, 11(1), 23–39.
Besag, F. M. C. (1998). Lamotrigine in the treatment of epilepsy in people with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 50–56.
Betts, T. (1990). Pseudoseizures: Seizures that are not epilepsy. Lancet, 336, 163–164.
Bhaumik, S., Branford, D., Duggirala, C., & Ismail, I. A. (1997). A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. Seizure, 6, 127–133.
Brodie, M. J., Yuen, A. W. C., & the 105 Study Group. (1997). Lamotrigine substitution study: Evidence for synergism with sodium valproate? Epilepsy Research, 26, 423–432.
Cataltepe, O., & Comair, Y. G. (1999). Focal resection in the treatment of neuronal migrational disorders. In P. Kotagal & H. O. Lüders (Eds.), The epilepsies: Etiology and prevention (pp. 87–92). San Diego, CA: Academic.
Collacott, R. A., Dignon, A., Hauck, A., & Ward, J. W. (1989). Clinical and therapeutic monitoring of epilepsy in a mental handicap unit. British Journal of Psychiatry,155, 522–525.
Coulter, D. L. (1993). Epilepsy and mental retardation: An overview. American Journal of Mental Retardation, 98, 1–11.
Deb, S. (1995). Electrophysiological correlates of psychopathology in individuals with mental retardation and epilepsy. Journal of Intellectual Disability Research, 39, 129–135.
Deb, S. (1997a). Epilepsy and mental retardation. Epilepsie Bulletin, 25, 91–94.
Deb, S. (1997b). Structural neuroimaging in mental retardation. British Journal of Psychiatry, 171, 417–419.
Deb, S. (1997c). Mental disorder in adults with mental retardation and epilepsy. Comprehensive Psychiatry, 38, 179–184.
Deb, S., & Ahmed, Z. (2000). Special conditions leading to mental retardation. In M. G. Gelder, N. Andreasen, & J. J. Lopez-Ibor (Eds.), New Oxford textbook of psychiatry (pp. 1953–1963). Oxford, UK: Oxford Press.
Deb, S., & Fraser, W. I. (1994). The use of psychotropic medication in people with learning disability: Towards rational prescribing. Human Psychopharmacology, 9, 259–272.
Deb, S., & Hunter, D. (1992). The effect of anticonvulsant medication on the psychopathology of adults with a mental handicap and epilepsy. Human Psychopharmacology, 7, 129–134.
Deb, S., & Joyce, J. (1999a). Characteristics of epilepsy in a population bases cohort of adults with learning disability. Irish Journal of Psychological Medicine, 16(1), 5–9.
Deb, S., & Joyce, J. (1999b). The use of anti-epileptic medication in a population based cohort of adults with learning disability and epilepsy. International Journal of Psychiatry in Clinical Practice, 3, 129–133.
Deb, S., Matthews, T., Holt, G., & Bouras, N. (Eds.). (2001). Practice guidelines for the assessment and diagnosis of mental health problems in adults with intellectual disability. London, UK: Pavilion.
Dobyns, W. B., & Truwit, C. L. (1995). Lissencephaly and other malformations of cortical development: 1995 update. Neuropediatrics, 26, 132–147.
Espie, C. A.,Watkins, J., Duncan, R., Espie, A., Sterrick, M., Brodie, M. J., et al. (2001). Development and validation of the Glasgow Epilepsy Outcome Scale (GEOS): A new instrument for measuring concerns about epilepsy in people with mental retardation. Epilepsia, 42(8), 1043–1051.
Eubanks, J. H., Puranam, R. S., Kleckner, N., Bettler, B., Heinemenn, B., & McNamara, J. O. (1993). The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22. 1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Proceedings of National Academy of Science (USA), 90, 178–182.
Forsgren, L., Edvinsson, S. O., Blomquist, H. K., Heijbel, J., & Sidenvall, R. (1990). Epilepsy in a population of mentally retarded children and adults. Epilepsy Research, 6(3), 234–248.
Friis, M. L. (1998). Valproate in the treatment of epilepsy in people with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 32–35.
Gaily, E., Granstrom, M.-L., & Lliukkonen, E. (1998). Oxcarbazepine in the treatment of epilepsy in children and adolescents with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 41–45.
Genton, P., Dravet, C., Bureau, N., Formosa, F., & Mesdjian, E. (1997). Aggravation of severe myoclonic epilepsy of infancy by lamotrigine. Epilepsia, 38(Suppl. 3), 32.
Goulden, K. J., Shinnar, S., Koller, H., Katz, M., & Richardson, S. A. (1991). Epilepsy in children with mental retardation: A cohort study. Epilepsia, 32, 690–697.
Henriksen, O., Bjørnaes, H., & Røste, G. K. (1999). Epilepsy surgery in mental retardation: The role of surgery. In M. Sillanpää, L. Gram, S. I. Johannessen, & T. Tomson (Eds.), Epilepsy and mental retardation (pp. 105–113). Philadelphia, PA: Wrightson Biomedical.
Holthausen, H., Tuxhorn, I., Pieper, T., Pannek, H., Lahl, R., & Oppel, F. (1999). Hemispherectomy in the treatment of neuronal migrational disorders. In P. Kotagal & H. O. Lüders (Eds.), The epilepsies: Etiology and prevention (pp. 93–102). San Diego, CA: Academic.
Isojärvi, J. I. T., & Tokola, R. A. (1998). Benzodiazepine in the treatment of epilepsy. Journal of Intellectual Disability Research, 42(S1), 80–92.
Kälväiinen, R. (1998). Tiagabine: A new therapeutic option for people with intellectual disability and partial epilepsy. Journal of Intellectual Disability Research, 42(S1), 63–67.
Kerr, M., Scheepers, M., Bowely, C., & Working Group of the International Association of the Scientific Study of Intellectual Disability. (2001). Clinical guidelines for the management of epilepsy in adults with an intellectual disability. Seizure, 10, 401–409.
Kerr, M. P. (1998). Topiramate: Uses in people with an intellectual disability who have epilepsy. Journal of Intellectual Disability Research, 42(S1), 74–79.
Lehesjoki, A.-E., Koskiniemi, M., Sistonen, P., Miao, J., Hästbacka, J., Norio, R., et al. (1991). Localisation of a gene for progressive myoclonus epilepsy to chromosome 21q22. Proceedings of National Academy of Science (USA), 88, 3696–3699.
Leppik, J. E., & Wolff, D. L. (1995). The place of felbamate in the treatment of epilepsy. CNS Drugs, 4, 294–301.
Li, L. M., Fish, D. R., Sisodiya, S. M., Shorvon, S. D., Alsanjari, N., & Stevens, J. M. (1995). High resolution magnetic resonance imaging in adults with partial or secondary generalised epilepsy attending a tertiary referral unit. Journal of Neurology, Neurosurgery, and Psychiatry, 59, 384–387.
Linuma, K., Minami, T., Cho, K., Kajii, N., & Tachi, N. (1998). Long term effects of Zonisamide in the treatment of epilepsy in children with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 68–73.
Livanianen, M. (1998). Phenytoin: Effective but insidious therapy for epilepsy in people with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 24–31.
Lund, J. (1985). Epilepsy and psychiatric disorder in the mentally retarded adults. Acta Psychiatrica Scandinavica, 72, 557–562.
McGrother, C. W., Hauck, A., Bhaumik, S., Thorp, C., & Taub, N. (1996). Community care for adults with learning disability and their carers: Needs and outcome from the Leicestershire register. Journal of Intellectual Disability Research, 40, 183–190.
Michelucci, R., Forti, A., Rubboli, G., Plasmati, R., Volpi, L., & Tassinari, C.-A. (1989). Mental retardation and behavioural disturbances related to epilepsy: A review. Brain Dysfunction, 2(1), 3–9.
Mikati, M. A., Choueri, R., Khurana, D. S., Riviello, J., Helmers, S., & Holmes, G. (1998). Gabapentin in the treatment of refractory partial epilepsy in children with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 57–62.
Pellock, J. M., & Hunt, P. A. (1996). A decade of modern epilepsy therapy in institutionalised mentally retarded patients. Epilepsy Research, 25, 263–268.
Ramsay, R. E., & Slater, J. D. (1993). Antiepileptic drugs in clinical development [In J. A. French, M. A. Dichter, & I. E. Leppik (Eds.), New anti-epileptic drug development, preclinical and clinical aspects]. Epilepsy Research, (Suppl. 10), 45–67.
Roberts, D.W. (1999). Corpus callosotomy in the treatment of neuronal migrational disorders. In P. Kotagal & H. O. Lüders (Eds.), The epilepsies: Etiology and prevention (pp. 103–112). San Diego, CA: Academic.
Rutter, M., Tizard, J., Yule, W., Graham, P., & Whitmore, K. (1976). Research report: Isle of Wight studies 1964–1974. Psychological Medicine, 76, 313–332.
Sabaz, M., Cairns, D. R., Lawson, J. A., Bleaseley, A. F., & Bye, A. M. E. (2001). The healthrelated quality of life of children with refractory epilepsy: A comparison of those with and without intellectual disability. Epilepsia, 42(5), 621–628.
Schachter, S. C., & Wheless, J. W. (2002). Vagus nerve stimulation therapy 5 year after approval: A comprehensive update. Neurology, 59(6, Suppl. 4), S1-S61.
Scheepers, M., Scheepers, B., & Clough, P. (1998). Midazolam via the intranasal route: An effective rescue medication for severe epilepsy in adults with learning disability. Seizure, 7, 509–512.
Shepherd, C., & Hosking, G. (1989). Epilepsy in school children with intellectual impairment in Sheffield: The size and nature of the problem and its implications in service provision. Journal of Mental Deficiency Research, 33, 511–514.
Sillanpää, M. (1973). Medico-social prognosis of children with epilepsy. Epidemiological study and analysis of 245 cases. Acta Paediatrica Scandinavica, (Suppl. 237), 1–104.
Sillanpää, M. (1999). Definitions and epidemiology. In M. Sillanpää, L. Gram, S. I. Johannessen, & T. Tomson (Eds.), Epilepsy and mental retardation (pp. 1–6). Philadelphia, PA: Wrightson Biomedical.
Stafstorm, C. E. (1999). Mechanisms of epilepsy in mental retardation: Insight from Angelman syndrome, Down syndrome and fragile X syndrome. In M. Sillanpää, L. Gram, S. I. Johannessen, & T. Tomson (Eds.), Epilepsy and mental retardation (pp. 7–40). Philadelphia, PA: Wrightson Biomedical.
Steffenburg, U., Hagberg, G., & Kyllerman, M. (1996). Characteristics of seizures in a population-based series of mentally retarded children with active epilepsy. Epilepsia, 37, 850–856.
Suzuki, H., Aihara, M., & Sugai, K. (1991). Severely retarded children in a defined area of Japan: Prevalence rate, associated disabilities and causes. Brain and Development, 23, 4–8.
Trevathan, E., Murphy, C. C., & Yeargin-Allsopp, M. (1997). Prevalence and descriptive epidemiology of Lennox–Gastaut syndrome among Atlanta children. Epilepsia, 38, 1283–1288.
Weisburg, H., & Alvarez, N. (1998). Carbamazepine in the treatment of epilepsy in people with intellectual disability. Journal of Intellectual Disability Research, 42(S1), 36–40.
Wisniewski, K. E., French, J. H., Fernando, S., Brown, W. T., Jenkins, E. C., Friedman, E., et al. (1985). Fragile X syndrome: Associated neurological abnormalities. Annals of Neurology, 18, 665–669.
Ylinen, A. (1998). Antiepleptic efficacy of Vigabatrin in people with severe epilepsy and intellectual disability. Journal of Intellectual Disability Research, 42(S1), 46–49.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this chapter
Cite this chapter
Deb, S. (2007). Epilepsy in People With Mental Retardation. In: Jacobson, J.W., Mulick, J.A., Rojahn, J. (eds) Handbook of Intellectual and Developmental Disabilities. Issues on Clinical Child Psychology. Springer, Boston, MA. https://doi.org/10.1007/0-387-32931-5_4
Download citation
DOI: https://doi.org/10.1007/0-387-32931-5_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-32930-7
Online ISBN: 978-0-387-32931-4
eBook Packages: Behavioral ScienceBehavioral Science and Psychology (R0)