Structure and Function in Dipeptidyl Peptidase IV and Related Proteins

  • Mark D. Gorrell
  • Xin M. Wang
  • Joohong Park
  • Katerina Ajami
  • Denise Ming Tse Yu
  • Heather Knott
  • Devanshi Seth
  • Geoffrey W. McCaughan
Part of the Advances in Experimental Medicine and Biology book series (volume 575)

9. Conclusions

Potential therapeutic applications of DPIV inhibitors have fuelled interest in understanding the biological roles of DPIV and its relatives. Such efforts are confounded by the ubiquitous expression of DPIV, inhibitor selectivity questions and the variety of identified substrates. DPIV is not essential, but is such a useful enzyme that all animal species express it. The enzyme activity’s ancient and primary function is probably nutritional, providing more complete proteolysis of food and recycled proteins. This function is unnecessary in well-fed humans. The development of selective inhibitors of proteolytic activity and identification of ligand binding activities in this gene family would lead to rapid advances in understanding the biology of the POP gene family.


Hepatic Stellate Cell Adenosine Deaminase Dipeptidyl Peptidase Fibroblast Activation Protein Gelatinase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Mark D. Gorrell
    • 1
  • Xin M. Wang
    • 1
  • Joohong Park
    • 1
  • Katerina Ajami
    • 1
  • Denise Ming Tse Yu
    • 1
  • Heather Knott
    • 1
  • Devanshi Seth
    • 1
  • Geoffrey W. McCaughan
    • 1
  1. 1.A. W. Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The Discipline of MedicineUniversity of SydneySydneyAustralia

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