Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin
FAP and DPIV overexpression in the HEK293 cell line reduced cell adhesion, migration and invasion on ECM components, increased proliferation and promoted apoptosis, independently of enzyme activity. These observations may aid an understanding of the roles of FAP and DPIV in tissue remodeling.
KeywordsGreen Fluorescent Protein 293T Cell Dipeptidyl Peptidase Discoidin Domain Receptor Fibroblast Activation Protein
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