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Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin

  • Xin M. Wang
  • Denise M. T. Yu
  • Geoffrey W. McCaughan
  • Mark D. Gorrell
Part of the Advances in Experimental Medicine and Biology book series (volume 575)

5. Conclusions

FAP and DPIV overexpression in the HEK293 cell line reduced cell adhesion, migration and invasion on ECM components, increased proliferation and promoted apoptosis, independently of enzyme activity. These observations may aid an understanding of the roles of FAP and DPIV in tissue remodeling.

Keywords

Green Fluorescent Protein 293T Cell Dipeptidyl Peptidase Discoidin Domain Receptor Fibroblast Activation Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Xin M. Wang
    • 1
  • Denise M. T. Yu
    • 1
  • Geoffrey W. McCaughan
    • 1
  • Mark D. Gorrell
    • 1
  1. 1.A. W. Morrow Gastroenterology and Liver Centre at Royal Prince Alfred HospitalCentenary Institute of Cancer Medicine and Cell Biology and the University of Sydney Discipline of MedicineSydneyAustralia

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