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Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation

  • Aliza Biton
  • Ute Bank
  • Michael Täger
  • Siegfried Ansorge
  • Dirk Reinhold
  • Uwe Lendeckel
  • Stefan Brocke
Part of the Advances in Experimental Medicine and Biology book series (volume 575)

5. Conclusions

In conclusion, these findings from in vitro and in vivo studies demonstrate that DP IV activity associated with CD26 plays an important role in the activation of autoreactive T cells. Moreover, inhibition of both DP IV/CD26 and APN/CD13 activity in vitro and in vivo provides a new approach to modulate T cell functions and tissue-specific autoimmunity in the CNS. These results may have important implications for the treatment of human diseases with a putative autoimmune pathogenesis. At present, major research efforts are directed at the investigation of DP IV/CD26 and APN/CD13 as potentially powerful and safe pharmacological targets. Our preliminary data raise the possibility that simultaneous inhibition of DP IV/CD26 and APN/CD13 may be advantageous over targeting a single ectopeptidase, and support the development of inhibitors with dual specificities for both ectopeptidases.

Keywords

Multiple Sclerosis Myelin Basic Protein Dipeptidyl Peptidase Magnetic Resonance Imaging Disease Magnetic Resonance Imaging Disease Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Aliza Biton
    • 1
  • Ute Bank
    • 2
  • Michael Täger
    • 2
  • Siegfried Ansorge
    • 2
  • Dirk Reinhold
    • 3
  • Uwe Lendeckel
    • 4
  • Stefan Brocke
    • 1
    • 5
  1. 1.Department of Pathology, Faculty of MedicineHebrew University-Hadassah Medical SchoolJerusalemIsrael
  2. 2.IMTMMagdeburgGermany
  3. 3.Institute of ImmunologyOtto-von-Guericke University MagdeburgMagdeburgGermany
  4. 4.Institute of Experimental Internal MedicineOtto-von-Guericke University MagdeburgMagdeburgGermany
  5. 5.Department of PharmacologyUniversity of Connecticut Health CenterFarmingtonUSA

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