Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?
Deregulation of DPP-IV-like activity was observed in synovial fluid and blood plasma of patients with RA and PsA. The cellular source of soluble DPP-IV-like enzymatic activity remains unclear.
Our results suggest significant contribution of intracellular DASH molecules to the total DPP-IV-like enzymatic activity, at least in FMNC from rheumatoid arthritis patients and in BMNC from both rheumatoid arthritis and osteoarthritis.
DASH subcellular distribution was different in FMNC in patients with rheumatoid arthritis compared to degenerative osteoarthritis.
Altered expression pattern and resulting distorted properties of whole DASH enzymatic activity in both systemic—blood—as well as local—joint—environments may impair processing of mediators involved in the inflammatory processes.
Together, DASH molecules, due to their enzymatic activity, may participate on the pathogenesis of RA and PsA and deserve attention as possible future therapeutic targets
KeywordsRheumatoid Arthritis Psoriatic Arthritis Dipeptidyl Peptidase Inflammatory Rheumatic Disease Altered Expression Pattern
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