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Possible Role of DP IV Inhibitors in Acne Therapy

  • Anja Thielitz
  • Dirk Reinhold
  • Robert Vetter
  • Uwe Lendeckel
  • Thilo Kähne
  • Ute Bank
  • Martin Helmuth
  • Klaus Neubert
  • Jürgen Faust
  • Roland Hartig
  • Sabine Wrenger
  • Christos C. Zouboulis
  • Siegfried Ansorge
  • Harald Gollnick
Part of the Advances in Experimental Medicine and Biology book series (volume 575)

3. Conclusions

The presented data provide evidence that DP IV is expressed on human sebocytes and most likely involved in regulation of sebocyte proliferation and cytokine production. The aminopeptidase inhibitors Lys[Z(NO2)]-thiazolidide and Lys[Z(NO2)]-pyrrolidide suppress proliferation of three cells types involved in acne initiation; moreover, they induce the anti-inflammatory cytokine IL-1RA in sebocytes and keratinocytes being capable to follicular hyperkeratosis, and they up-regulate the immunosuppressive cytokine transforming growth factor-β1 in P. acnes-stimulated T cells.

In summary, DP IV inhibitors affect proliferation, differentiation and inflammation processes in acne-involved cells in a therapeutic manner (Table 1). Thus they might in the future act as promising new agents for acne therapy.

Keywords

Peripheral Blood Mononuclear Cell Alopecia Areata Dipeptidyl Peptidase Keratinocyte Proliferation HACAT Keratinocytes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Anja Thielitz
    • 1
  • Dirk Reinhold
    • 2
  • Robert Vetter
    • 1
  • Uwe Lendeckel
    • 3
  • Thilo Kähne
    • 3
  • Ute Bank
    • 4
  • Martin Helmuth
    • 4
  • Klaus Neubert
    • 5
  • Jürgen Faust
    • 5
  • Roland Hartig
    • 2
  • Sabine Wrenger
    • 2
  • Christos C. Zouboulis
    • 6
  • Siegfried Ansorge
    • 4
  • Harald Gollnick
    • 1
  1. 1.Department of Dermatology and VenereologyOtto-von-Guericke UniversityMagdeburgGermany
  2. 2.Institute of ImmunologyOtto-von-Guericke UniversityMagdeburgGermany
  3. 3.Institute of Experimental Internal MedicineOtto-von-Guericke UniversityMagdeburgGermany
  4. 4.IMTMMagdeburgGermany
  5. 5.Institute of Biochemistry, Department of Biochemistry and BiotechnologyMartin-Luther-University Halle WittenbergGermany
  6. 6.Department of DermatologyCharité University Medicine BerlinBerlinGermany

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