3. Conclusions
The presented data provide evidence that DP IV is expressed on human sebocytes and most likely involved in regulation of sebocyte proliferation and cytokine production. The aminopeptidase inhibitors Lys[Z(NO2)]-thiazolidide and Lys[Z(NO2)]-pyrrolidide suppress proliferation of three cells types involved in acne initiation; moreover, they induce the anti-inflammatory cytokine IL-1RA in sebocytes and keratinocytes being capable to follicular hyperkeratosis, and they up-regulate the immunosuppressive cytokine transforming growth factor-β1 in P. acnes-stimulated T cells.
In summary, DP IV inhibitors affect proliferation, differentiation and inflammation processes in acne-involved cells in a therapeutic manner (Table 1). Thus they might in the future act as promising new agents for acne therapy.
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Thielitz, A. et al. (2006). Possible Role of DP IV Inhibitors in Acne Therapy. In: Lendeckel, U., Reinhold, D., Bank, U. (eds) Dipeptidyl Aminopeptidases. Advances in Experimental Medicine and Biology, vol 575. Springer, Boston, MA . https://doi.org/10.1007/0-387-32824-6_17
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