Abstract
In eukaryotic cells, gene expression is controlled at multiple levels that could be grouped in two large categories, transcriptional and post-transcriptional regulatory events. Regulation of gene expression at the level of transcription is the major determinant of the initiation of protein synthesis and of the level of gene expression. However, there is increasing evidence of the important contribution of the post-transcriptional control mechanisms in determining and fine-tuning the final amount of the synthesized protein product. Post-transcriptional regulatory mechanisms could be grouped into events that modulate mRNA stability, localization, translation, as well as protein stability and modifications.
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Lerner, L.E., Piri, N., Farber, D.B. (2006). Transcriptional and Post-Transcriptional Regulation of the Rod cGMP-Phosphodiesterase β-Subunit Gene. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 572. Springer, Boston, MA. https://doi.org/10.1007/0-387-32442-9_32
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DOI: https://doi.org/10.1007/0-387-32442-9_32
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