Abstract
Retinal neovascularisation is a major clinical complication of diabetic retinopathy that takes place late in the disease process and constitutes the most damaging phase resulting in loss of vision (Klein et al., 1984). Neovascularisation is defined as the growth of new blood vessels which, in a disease process such as diabetic retinopathy, occurs in abnormal retinal locations. Long term consequences of retinal neovascularisation include the formation of epiretinal membranes and retinal detachment (Smith et al., 1999). In addition, new blood vessels lack a patent blood retinal barrier and exhibit leukostasis presumably resulting in cytotoxic damage (Ishida et al., 2003; Qaum et al., 2001).
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References
Aiello, L. P., Avery, R. L., Arrigg, P. G., Keyt, B. A., Jampel, H. D., Shah, S. T., Pasquale, L. R., Thieme, H., Iwamoto, M. A., Park, J. E., and et al., 1994, Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders, N Engl J Med 331(22):1480–7.
Amin, R. H., Frank, R. N., Kennedy, A., Eliott, D., Puklin, J. E., and Abrams, G. W., 1997, Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy, Invest Ophthalmol Vis Sci 38(1):36–47.
Ishida, S., Usui, T., Yamashiro, K., Kaji, Y., Ahmed, E., Carrasquillo, K. G., Amano, S., Hida, T., Oguchi, Y., and Adamis, A. P., 2003, VEGF164 is proinflammatory in the diabetic retina, Invest Ophthalmol Vis Sci 44(5):2155–62.
Klein, R., Klein, B. E., Moss, S. E., Davis, M. D., and DeMets, D. L., 1984, The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years, Arch Ophthalmol 102(4):527–32.
Lai, C-M., Dunlop, S. A., May, L. A., Gorbatov, M., Brankov, M., Shen, W-Y., Binz, N., Graham, C. E., Barry, C. J., Constable, I. J., Beazley, L. D., and Rakoczy, P. E., 2004, Generation of transgenic mice with mild and severe retinal neovascularisation. Brit J Ophthalmol (in press).
Lu, M., Perez, V. L., Ma, N., Miyamoto, K., Peng, H. B., Liao, J. K., and Adamis, A. P., 1999, VEGF increases retinal vascular ICAM-1 expression in vivo, Invest Ophthalmol Vis Sci 40(8):1808–12.
Ohno-Matsui, K., Hirose, A., Yamamoto, S., Saikia, J., Okamoto, N., Gehlbach, P., Duh, E. J., Hackett, S., Chang, M., Bok, D., Zack, D. J., and Campochiaro, P. A., 2002, Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment, Am J Pathol 160(2):711–9.
Okamoto, N., Tobe, T., Hackett, S. F., Ozaki, H., Vinores, M. A., LaRochelle, W., Zack, D. J., and Campochiaro, P. A., 1997, Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization, Am J Pathol 151(1):281–91.
Qaum, T., Xu, Q., Joussen, A. M., Clemens, M. W., Qin, W., Miyamoto, K., Hassessian, H., Wiegand, S. J., Rudge, J., Yancopoulos, G. D., and Adamis, A. P., 2001, VEGF-initiated blood-retinal barrier breakdown in early diabetes, Invest Ophthalmol Vis Sci 42(10):2408–13.
Smith, G., McLeod, D., Foreman, D., and Boulton, M., 1999, Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy, Br J Ophthalmol 83(4):486–94.
Sone, H., Kawakami, Y., Okuda, Y., Sekine, Y., Honmura, S., Matsuo, K., Segawa, T., Suzuki, H., and Yamashita, K., 1997, Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes, Diabetologia 40(6):726–30.
Tolentino, M. J., McLeod, D. S., Taomoto, M., Otsuji, T., Adamis, A. P., and Lutty, G. A., 2002, Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate, Am J Ophthalmol 133(3):373–85.
Tolentino, M. J., Miller, J. W., Gragoudas, E. S., Jakobiec, F. A., Flynn, E., Chatzistefanou, K., Ferrara, N., and Adamis, A. P., 1996, Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate, Ophthalmology 103(11):1820–8.
Witmer, A. N., Vrensen, G. F., Van Noorden, C. J., and Schlingemann, R. O., 2003, Vascular endothelial growth factors and angiogenesis in eye disease, Prog Retin Eye Res 22(1):1–29.
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van Eeden, P.E. et al. (2006). Characterisation of a Model for Retinal Neovascularisation. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 572. Springer, Boston, MA. https://doi.org/10.1007/0-387-32442-9_24
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DOI: https://doi.org/10.1007/0-387-32442-9_24
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