Postnatal Changes in Gene Expression of Subfamilies of TASK K+ Channels in Rat Carotid Body
The carotid body (CB) is a chemosensory organ monitoring blood O2 level, CO2 level, and pH. It is known that CB O2 sensitivity is minimal after birth and increases with age (Bamford, 1999), but the mechanisms of CB development are poorly understood. Previous studies have shown that CB glomus cell background K+ current is inhibited by acute hypoxia and glomus cell O2- sensitive background currents increase with age (Kim, 2003). It has been proposed these currents are carried by TASK-like K+ channels. Therefore, we hypothesized that expression of one or several TASK K+ channels might change during CB development and contribute to the development of glomus cell oxygen sensitivity.
KeywordsCarotid Body Glomus Cell Target Gene Transcript Arterial Chemoreceptor Task Gene Expression
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