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Postnatal Changes in Gene Expression of Subfamilies of TASK K+ Channels in Rat Carotid Body

  • INSOOK KIM
  • JUNG H. KIM
  • JOHN L. CARROLL
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

The carotid body (CB) is a chemosensory organ monitoring blood O2 level, CO2 level, and pH. It is known that CB O2 sensitivity is minimal after birth and increases with age (Bamford, 1999), but the mechanisms of CB development are poorly understood. Previous studies have shown that CB glomus cell background K+ current is inhibited by acute hypoxia and glomus cell O2- sensitive background currents increase with age (Kim, 2003). It has been proposed these currents are carried by TASK-like K+ channels. Therefore, we hypothesized that expression of one or several TASK K+ channels might change during CB development and contribute to the development of glomus cell oxygen sensitivity.

Keywords

Carotid Body Glomus Cell Target Gene Transcript Arterial Chemoreceptor Task Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • INSOOK KIM
    • 1
  • JUNG H. KIM
    • 2
  • JOHN L. CARROLL
    • 1
  1. 1.Dept of PediatricsUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Dept of Systems EngineeringUniversity of Arkansas at Little RockLittle RockUSA

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