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Modulation of Gene Expression in Subfamilies of TASK K+ Channels by Chronic Hyperoxia Exposure in Rat Carotid Body

  • INSOOK KIM
  • DAVID F. DONNELLY
  • JOHN L. CARROLL
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

The carotid body (CB) is a chemosensory organ which detects a decrease in PaO2 or pHa and increases spiking levels on the carotid sinus nerve. Chemosensitivity normally increases after birth but this maturation is impaired by post-natal exposure to hyperoxia, resulting in a large reduction in spiking rates during normoxia and hypoxia (Donnelly, 2005) and reduction in carotid type I cell depolarization in response to anoxia (Kim, 2003). Previous studies have indicated that detection of hypoxia or acidity is mediated by modulation of a leak potassium conductance of which TASK-1 and TASK-3 are likely candidates. Accordingly, we hypothesized that post-natal hyperoxia exposure will alter the developmental profile of TASK channels within the carotid body cells.

Keywords

Carotid Body Glomus Cell Task Channel Hyperoxia Exposure Carotid Sinus Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • INSOOK KIM
    • 1
  • DAVID F. DONNELLY
    • 2
  • JOHN L. CARROLL
    • 1
  1. 1.Dept of PediatricsUniversity of Arkansas Medical SciencesLittle RockUSA
  2. 2.Dept of PediatricsYale UniversityNew HavenUSA

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