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Hypoxic Modulation of the Cholinergic System in the Cat Carotid Glomus Cell

  • JEFFREY A. MENDOZA
  • IRENE CHANG
  • MACHIKO SHIRAHATA
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

The carotid body is a primary sensory organ for arterial hypoxia. Chemosensory glomus cells in the carotid body release neurotransmitters, including ACh, in response to hypoxia. The release of neurotransmitters from the glomus cell, a putative chemoreceptor cell, appears to be triggered by an influx of calcium and subsequent increase in intracellular calcium ([Ca2+]i). Several reports indicate that L-type and some other types of voltage-gated calcium channels are responsible for neurotranmitter release from glomus cells (Gonzalez et al., 1994). These channels are activated by depolarization of the cell membrane. However, the speed and the degree of depolarization in glomus cells may not be sufficient to activate voltage-gated Ca2+ channels at mild hypoxia (Chou et al., 1998), where afferent neural activity from the carotid body starts increasing. This discrepancy led us to search for other mechanisms which elevate [Ca2+]i followed by neurotransmitter release.

Keywords

Nicotinic Receptor Carotid Body Krebs Solution Cholinergic Agonist Glomus Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • JEFFREY A. MENDOZA
    • 1
  • IRENE CHANG
    • 1
  • MACHIKO SHIRAHATA
    • 1
  1. 1.Departments of Environmental Health SciencesJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA

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