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Stimulus Interaction between Hypoxia and Hypercapnia in the Human Peripheral Chemoreceptors

  • TORU TAKAHASHI
  • SHINOBU OSANAI
  • SHOKO NAKAO
  • MASAAKI TAKAHASHI
  • HITOSHI NAKANO
  • YOSHINOBU OHSAKI
  • KENJIRO KIKUCHI
Conference paper
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

The combined effects of hypoxia and hypercapnia on ventilation were demonstrated synergistic in mammalian. ( Neilson 1952). Although stimulus interaction between hypoxia and hypercapnia in peripheral chemoreceptors has been clearly demonstrated in experimental animals, there have been limited studies targeted in human. It is difficult to distinguish peripheral chemoreception from central chemoreception in steady-state ventilatory response to hypercapnia, since inspired hypercapnic gas stimulates both peripheral and central chemoreceptor. On the contrary, “two breaths method” has been used to estimate the peripheral chemoreceptor activity in human. In this method, transient alteration of ventilation with two breaths of hypoxic gas or hypercapnic gas may show the peripheral chemoreceptor activity. In the present study, we evaluate the ventilatory response to combined effects of hypoxia and hypercapnia in the peripheral chemosensitivity in healthy human by using two breaths method.

Keywords

Tidal Volume Obstructive Sleep Apnoea Ventilatory Response Obstructive Sleep Apnoea Syndrome Peripheral Chemoreceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer 2006

Authors and Affiliations

  • TORU TAKAHASHI
    • 1
  • SHINOBU OSANAI
    • 1
  • SHOKO NAKAO
    • 1
  • MASAAKI TAKAHASHI
    • 1
  • HITOSHI NAKANO
    • 1
  • YOSHINOBU OHSAKI
    • 1
  • KENJIRO KIKUCHI
    • 1
  1. 1.First Department of MedicineAsahikawa Medical CollegeAsahikawaJapan

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