Effects of Low-Dose Methazolamide on the Control of Breathing in Cats
Inhibitors of carbonic anhydrase (CA) have complex effects on respiration. Many cells and tissues that are involved in the control of breathing contain various isoforms of CA, e.g., red cells, carotid bodies, lung and brain capillary endothelial cells, muscle and neurons closely associated with central chemoreceptors (1-9). In human and cats, low intravenous doses of acetazolamide have both stimulatory and inhibitory effects on the control of breathing. (10, 11). One of the inhibitory effects applies to the peripheral chemoreceptors because acetazolamide has been shown to reduce the hypoxic response and also the O2-CO2 interaction that is known to reside the carotid bodies (10,12,13).
KeywordsCarbonic Anhydrase Carotid Body Ventilatory Response Brain Capillary Endothelial Cell Peripheral Chemoreceptor
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