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The Cell-Vessel Architecture Model for the Central Respiratory Chemoreceptor

  • YASUMASA OKADA
  • SHUN-ICHI KUWANA
  • YOSHITAKA OYAMADA
  • ZIBIN CHEN
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

The group of Loeschcke established that the superficial ventrolateral medulla contains chemosensitive regions (see the reviews [1-3]). Later, the group of Nattie conducted experiments of acetazolamide microinjection that induced local tissue acidosis, and found that the midline region (raphe), nucleus tractus solitarii and locus coeruleus are also chemosensitive (see the review [4]). To map the medullary chemosensitive regions using a more physiological stimulation technique, we microinjected CO2-enriched saline into various regions of the in vivo and in vitro rat medulla, and found that the superficial midline, parapyramidal and ventrolateral regions are chemosensitive [5]. These findings extend other microinjection studies [6,7] that showed only that the superficial ventrolateral medulla is chemosensitive.

Keywords

Nucleus Tractus Solitarii Ventrolateral Medulla Ventral Respiratory Group Ventral Medulla Fine Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • YASUMASA OKADA
    • 1
  • SHUN-ICHI KUWANA
    • 2
  • YOSHITAKA OYAMADA
    • 3
  • ZIBIN CHEN
    • 4
  1. 1.Department of MedicineKeio University Tsukigase Rehabilitation CenterShizuokaJapan
  2. 2.Department of PhysiologyTeikyo UniversityTokyoJapan
  3. 3.Department of Pulmonary Medicine, School of MedicineKeio UniversityTokyoJapan
  4. 4.Department of Biochemical and Analytical Pharmacology, GlaxoSmithKlineResearch Triangle ParkUSA

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