Differential Expression of Oxygen Sensitivity in Voltage-Dependent K Channels in Inbred Strains of Mice
Oxygen sensitivity of voltage-dependent K channels (Kv channels) in chemosensory glomus cells is responsible for hypoxic chemotransduction processes in the carotid body. Human studies in twins and in individuals over time suggest that hypoxic sensitivity of the carotid body is genetically controlled (Collins et al., 1978; Kawakami et al., 1982; Nishimura et al., 1991; Thomas et al., 1993). The concept is further confirmed in the studies using inbred strains of mice (Tankersley et al., 1994; Campen et al., 2004) and rats (Weil et al., 1998) which are genetically almost identical within a strain. In these studies, respiratory or cardiovascular responses to hypoxia vary among several strains, but are similar within a strain. Thus, some proteins which are differentially expressed in individuals due to genetic differences likely cause variable carotid body responses. We have hypothesized that differential expression of oxygensensitive Kv channels contributes to the differences in hypoxic sensitivity of DBA/2J and A/J strains of mice.
KeywordsInbred Strain Carotid Body Krebs Solution Glomus Cell Oxygen Sensitivity
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