Abstract
Oxygen sensitivity of voltage-dependent K channels (Kv channels) in chemosensory glomus cells is responsible for hypoxic chemotransduction processes in the carotid body. Human studies in twins and in individuals over time suggest that hypoxic sensitivity of the carotid body is genetically controlled (Collins et al., 1978; Kawakami et al., 1982; Nishimura et al., 1991; Thomas et al., 1993). The concept is further confirmed in the studies using inbred strains of mice (Tankersley et al., 1994; Campen et al., 2004) and rats (Weil et al., 1998) which are genetically almost identical within a strain. In these studies, respiratory or cardiovascular responses to hypoxia vary among several strains, but are similar within a strain. Thus, some proteins which are differentially expressed in individuals due to genetic differences likely cause variable carotid body responses. We have hypothesized that differential expression of oxygensensitive Kv channels contributes to the differences in hypoxic sensitivity of DBA/2J and A/J strains of mice.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Campen M.J., Tagaito Y., Li J., Balbir A., Tankersley C.G., Smith P., Schwartz A., O'Donnell C.P., 2004. Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice. Physiol. Genomics 20: 15–20.
Collins D.D., Scoggin C.H., Zwillich C.W., Weil J.V., 1978. Hereditary aspects of decreased hypoxic response. J. Clin. Invest. 62: 105–110.
Conforti L., Bodi I., Nisbet J.W., Millhorn D.E., 2000. O2-sensitive K+ channels: role of the Kvl.2-subunit in mediating the hypoxic response. J. Physiol. 524: 783–793.
Gribkoff V.K., Starrett J.E., Dworetzky S.I., 2001. Maxi-K potassium channels: Form, function, and modulation of a class of endogenous regulators of intracellular calcium. Neuroscientist 7: 166–177.
Kawakami Y., Yoshikawa T., Shida A., Asanuma Y., Murao M., 1982. Control of breathing in young twins. J. Appl. Physiol. 52: 537–542.
Meera P., Wallner M., Toro L., 2000. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Proc. Natl. Acad. Sci. U S A 97: 5562–5567.
Nishimura M., Yamamoto M., Yoshioka A., Akiyama Y., Kishi F., Kawakami Y., 1991. Longitudinal analyses of respiratory chemosensitivity in normal subjects. Am. Rev. Respir. Dis. 143: 1278–1281.
Orio P., Rojas P., Ferreira G., Latorre R., 2002. New disguises for an old channel: MaxiK channel beta-subunits. News Physiol. Sci. 17: 156–161.
Rubin A.E., Polotsky V.Y., Balbir A., Krishnan J.A., Schwartz A.R., Smith P.L., Fitzgerald R.S., Tankersley C.G., Shirahata M., O'Donnell C.P., 2003. Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains. Am. J. Resp. Crit. Care Med. 168: 1520–1527.
Sanchez D., Lopez-Lopez J.R., Perez-Garcia M.T., Sanz-Alfayate G., Obeso A, Ganfornina MD, Gonzalez C, 2002. Molecular identification of Kvalpha subunits that contribute to the oxygen-sensitive K+ current of chemoreceptor cells of the rabbit carotid body. J Physiol. 542: 369–382.
Shirahata M., Sham J.S., 1999. Roles of ion channels in carotid body chemotransmission of acute hypoxia. Jpn. J. Physiol. 49: 213–228.
Tankersley C.G., Fitzgerald R.S., Kleeberger S.R. (1994) Differential control of ventilation among inbred strains of mice. Am. J. Physiol. 267: R1371-7.
Thomas D.A., Swaminathan S., Beardsmore C.S., McArdle E.K., MacFadyen U.M., Goodenough PC, Carpenter R, Simpson H (1993) Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants. Am. Rev. Respir. Dis. 148: 1605–1609.
Weiger T.M., Holmqvist M.H., Levitan I.B., Clark F.T., Sprague S., Huang W.J., Ge P., Wang C., Lawson D., Jurman M.E., Glucksmann M.A., Silos-Santiago I, DiStefano PS, Curtis R, 2000. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. J. Neurosci. 20: 3563–3570.
Weil J.V., Stevens T., Pickett C.K., Tatsumi K., Dickinson M.G., Jacoby C.R., Rodman D.M 1998. Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats. Am. J. Physiol. 274: L767–L774.
Yamaguchi S., Balbir A., Schofield B., Coram J., Tankersley C.G., Fitzgerald R.S., O'Donnell CP, Shirahata M. 2003, Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice. J. Appl. Physiol. 94: 1536–1542.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer
About this paper
Cite this paper
OTSUBO, T., YAMAGUCHI, S., OKUMURA, M., SHIRAHATA, M. (2006). Differential Expression of Oxygen Sensitivity in Voltage-Dependent K Channels in Inbred Strains of Mice. In: Hayashida, Y., Gonzalez, C., Kondo, H. (eds) THE ARTERIAL CHEMORECEPTORS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 580. Springer, Boston, MA. https://doi.org/10.1007/0-387-31311-7_32
Download citation
DOI: https://doi.org/10.1007/0-387-31311-7_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-31310-8
Online ISBN: 978-0-387-31311-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)