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Neuroglobin, a New Oxygen Binding Protein is Present in the Carotid Body and Increases after Chronic Intermittent Hypoxia

  • C. DI GIULIO
  • G. BIANCHI
  • M. CACCHIO
  • L. ARTESE
  • M. PICCIRILLI
  • V. VERRATTI
  • R. VALERIO
  • R. ITURRIAGA
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

Neuroglobin (Ngb), a 151-amino-acid protein with a predicted molecular mass of 17 kD was recently identified as a member of the vertebrate globin family (Burmester and Hankeln, 2004; Mammen et al., 2002). Ngb, is predominantly expressed in nerve cells, particularly in the brain and in the retina (Burmester et al., 2000; Zhu et al., 2002), but is also expressed in other tissues (Burmester and Hankeln, 2004). The protein has three-on-three -helical globin fold and are endowed with a hexa-coordinate heme-Fe atoms, which displays O2 affinities and binds CO (Burmester & Hankeln, 2004).The physiological role of Ngb is not well understood, but it has been proposed that Ngb participates in several processes such as oxygen transport, oxygen storage, and NO detoxification (Burmester and Hankeln, 2004). Ngb as well as hemoglobin is a respiratory protein that reversibly binds gaseous ligands (NO and O2) by means of the Fe-containing porphyrin ring. Ngb is concentrated in neuronal cellular regions that contain mitochondria, and its distribution is correlated with oxygen consumption rates (Pesce et al., 2003).

Keywords

Oxygen Consumption Rate Carotid Body Chronic Intermittent Hypoxia Glomus Cell High Oxygen Consumption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • C. DI GIULIO
    • 1
  • G. BIANCHI
    • 1
  • M. CACCHIO
    • 1
  • L. ARTESE
    • 2
  • M. PICCIRILLI
    • 2
  • V. VERRATTI
    • 1
  • R. VALERIO
    • 1
  • R. ITURRIAGA
    • 3
  1. 1.Department of Biomedical Sciences“G. d’Annunzio” UniversityChietiItaly
  2. 2.Department. of Odontostomastology“G. d’Annunzio” UniversityChietiItaly
  3. 3.Laboratory of NeurobiologyP. Catholic University of ChileSantiagoChile

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