Does AMP-activated Protein Kinase Couple Hypoxic Inhibition of Oxidative Phosphorylation to Carotid Body Excitation?
The carotid bodies are the primary peripheral chemoreceptors. They respond to a fall in blood pO2, a rise in blood pCO2 and consequent fall in pH by releasing neurotransmitters. These increase the firing frequency of the carotid sinus nerves which then correct the pattern of breathing via an action at the brainstem. It is now generally accepted that the type 1 or glomus cells are the chemosensory element within the carotid body. However, the precise mechanism by which a fall in pO2 excites the neurotransmitter rich type 1 cells has been the subject of hearty debate for decades now.
KeywordsCarotid Body Adenylate Kinase Mitochondrial Oxidative Phosphorylation Glomus Cell Carotid Sinus Nerve
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- Evans AM. Hypoxia cell metabolism and cADPR accumulation. In: Yuan X-J (ed). Hypoxic pulmonary vasoconstriction: cellular and molecular mechanisms. Kluwer Academic Publications, p 313–338Google Scholar
- Evans AM, Hardie DG, Galione A, Peers C, Kumar P and Wyatt CN. AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cADPR dependent Calcium mobilization from the sarcoplasmic reticulum and/or transmembrane Calcium influx in Oxygen-sensing cells. In: Signalling pathways in acute Oxygen sensing. 2005. Novartis open meeting 272.Google Scholar
- Hallows KR, Kobinger GP, Wilson JM, Witters LA and Foskett JK. Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am. J Physiol 2003; 284, 1297–1308.Google Scholar
- Heymans C, Bouckaert JJ and Dautreband L. Sinus carodidien et reflexes respiratoires; sensibilite des sines carotidiens aux substances chimiques. Acion stimulante respiratoire reflex du sulfre de sodium, du cyanure de potassium, de la nicotine et de la lobeline. Arch. Int. Pharmacodyn. Ther. 1931; 40, 54–91.Google Scholar
- Krylov SS and Anichkov SV. The effect of metabolic inhibitors on carotid chemoreceptors. In Torrance RW (ed). Arterial Chemoreceptors. Blackwell, Oxford. P 103–109.Google Scholar
- Light PE, Wallace CH and Dyck JR. Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated Sodium currents in ventricular myocytes. Circulation. 2003; 1962–1965.Google Scholar
- Wyatt CN, Kumar P, Peers C, Kang P, Hardie DG and Evans AM. The potential role for AMP-kinase in hypoxic chemotransduction of rat carotid body. J. Physiol-Lond. 2004; 560P, C44.Google Scholar